Hurley Staging Training for Hidradenitis Suppurativa Patients.

Introduction: The Hurley staging system is a grading system utilized to measure hidradenitis suppurativa (HS) severity. Teaching patients to grade the severity of HS may aid in the accuracy of self-reporting for research and clinical purposes. Thus, this study aimed to determine the utility of a Hurley stage learning module (HSLM) for participants to grade images of HS.

Prognosis of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Cohort Study of 216 Patients in an Inpatient Dermatology Department.

Introduction: Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse reactions. However, only a few studies have investigated the clinicodemographic and laboratory parameters predicting SJS and TEN outcomes other than mortality, such as severe complications or increased length of hospital stays. Our objectives are to identify admission risk factors predictive of severe complications and the accompanying clinical or biochemical markers associated with prolonged hospitalization.

Biologic Use During Pregnancy and Breastfeeding in Dermatology: An Evidence-Based Review.

Biologic medications have revolutionized the treatment of many dermatologic conditions. However, their use during pregnancy and breastfeeding is a subject of ongoing concern due to limited data on their safety in these populations. As the course of many inflammatory skin conditions is unpredictable during pregnancy and may worsen, biologics are important therapeutic tools for disease stabilization in this patient population.

Adherence to Hidradenitis Suppurativa Treatment.

Hidradenitis suppurativa (HS) is a chronic, debilitating skin condition that requires multimodal treatment. Adherence remains a significant challenge for many patients due to complex nature of treatment, thus presenting a barrier to management success. This review summarizes the current literature on the factors associated with adherence to medications, and lifestyle behaviors in patients with HS and proposes strategies to improve adherence.

Perspectives of Emergency Medicine Physicians on Hidradenitis Suppurativa Care.

Introduction: Hidradenitis suppurativa (HS) is a chronic skin condition that often requires acute care during periods of flares, with many patients visiting the emergency department over 5 times before receiving a proper diagnosis. However, little is known about emergency medicine (EM) providers' experiences and knowledge of HS management.

Methods: In this study, an anonymous survey was distributed to EM providers to identify knowledge and practice gaps in HS care.

A New Approach for the Fabrication of Tetragonal BaTiO₃ Nanoparticles.

For the first time, the BaTiO₃ nano-sized particles were obtained through solid-state reaction by employing the titanium oxide nanoparticle. Meanwhile, by using TiO₂ with micro-sized particles, the synthesized BaTiO₃ shows the micro-sized. The XRD pattern confirms that both BaTiO₃ nano-sized and micro-sized particles display the tetragonal structure.

The Dependence of Structure, Morphology, and Photocatalytic Properties of SnO₂ Nanoparticles Prepared via Hydrothermal Method on Annealing Temperature.

New high-performance photocatalytic materials are required to effectively treat water pollution. The effect of annealing temperature on the photocatalytic activities of tin dioxide (SnO₂) nanoparticles is investigated in this work. SnO₂ nanoparticles are prepared via a hydrothermal method and annealing at various temperatures ranging from as-prepared to 900 °C.

Air pollution caused by phthalates and cyclic siloxanes in Hanoi, Vietnam: Levels, distribution characteristics, and implications for inhalation exposure.

Contamination status and distribution characteristics of ten phthalic acid esters (PAEs) and three cyclic volatile methyl siloxanes (CSs) were determined in the air (gas and particle) samples collected from indoor and outdoor spaces of several chemistry laboratories, offices, and homes from urban area of Hanoi, the capital city of Vietnam. Air concentrations of Σ10PAEs (median 688; range 142-2390 ng m) and Σ3CSs (171; not detected-1100 ng m) in the indoor air samples were significantly higher than those measured in the outdoor ones (Σ10PAEs: 161; 34.1-515 ng m and Σ3CSs: 43.

Effects of annealing temperature on the structure, morphology, and photocatalytic properties of SnO/rGO nanocomposites.

Water pollution abatement is a problem in today's society that requires urgent attention. Moreover, photocatalysts are an effective method to treat environmental pollution, and SnO/reduced graphene oxide composite photocatalysts have been extensively studied in recent years. The synthesis parameters for these photocatalysts significantly affect their morphologies, structures, and properties.

Metastasis of cholangiocarcinoma is promoted by extended high-mannose glycans.

Membrane-bound oligosaccharides form the interfacial boundary between the cell and its environment, mediating processes such as adhesion and signaling. These structures can undergo dynamic changes in composition and expression based on cell type, external stimuli, and genetic factors. Glycosylation, therefore, is a promising target of therapeutic interventions for presently incurable forms of advanced cancer.

Micronutrients in Atopic Dermatitis: A Systematic Review.

The pathophysiology of atopic dermatitis (AD) involves a complex interplay between immune system dysfunction, genetics, and environmental factors. It is well known that nutritional status is essential to a proper functioning immune system, leading to a highly debated question regarding the role of dietary factors in the pathogenesis of AD. Food allergies and elimination diets have been broadly studied in atopy; however, less consideration has been given to how vitamins, minerals, and other micronutrients influence the risk for AD and severity of symptoms.

Neurosurgical Oncology in Vietnam.

Background: In conjunction with Vietnam's unparalleled economic growth over the past 20 years, our scope of neurosurgical interventions has considerably diversified throughout this time period.

Methods: Although still appreciably limited, healthcare resources and infrastructure have expanded and shifted the focus within neurosurgery at Ho Chi Minh City's Cho Ray Hospital from head trauma (which remains highly prevalent) to an equal proportion of elective cases for vascular lesions, tumors, and degenerative spine disease. Arguably the most significant progress throughout the new millennium has been achieved in the realm of neurosurgical oncology.

Pain and Itch Are Dual Burdens in Atopic Dermatitis.

Background: Despite being widely reported by patients with atopic dermatitis (AD), pain symptoms, unlike itch, have not been widely assessed.

Objective: The aim of the study was to understand the distinct pain symptoms in patients with AD.

Methods: Responses from an anonymous questionnaire were collected from our eczema clinic (in-person survey) and collaboration with Global Parents for Eczema Research Group and the National Eczema Association (online survey) to assess skin pain among patients with AD 5 years and older.

New and emerging targeted systemic therapies: a new era for atopic dermatitis.

Purpose: This is a review of emerging targeted, systemic therapies for atopic dermatitis (AD). The information presented aims to provide dermatologists with updated therapeutic options, stimulate academic interest, and spark future research.

Material And Methods: Extensive search of ClinicalTrials.

Oncolytic Reactivation of KSHV as a Therapeutic Approach for Primary Effusion Lymphoma.

Primary effusion lymphoma (PEL) is an aggressive subtype of non-Hodgkin lymphoma caused by Kaposi's sarcoma-associated herpesvirus (KSHV) infection. Currently, treatment options for patients with PEL are limited. Oncolytic viruses have been engineered as anticancer agents and have recently shown increased therapeutic promise.

MEK inhibitors and their potential in the treatment of advanced melanoma: the advantages of combination therapy.

The treatment of melanoma has improved markedly over the last several years with the advent of more targeted therapies. Unfortunately, complex compensation mechanisms, such as those of the mitogen-activated protein kinase (MAPK) pathway, have limited the clinical benefit of these treatments. Recently, a better understanding of melanoma resistance mechanisms has given way to intelligently designed multidrug regimes.

Endothelial β-Catenin Signaling Is Required for Maintaining Adult Blood-Brain Barrier Integrity and Central Nervous System Homeostasis.

Background: The blood-brain barrier (BBB) formed by brain endothelial cells interconnected by tight junctions is essential for the homeostasis of the central nervous system. Although studies have shown the importance of various signaling molecules in BBB formation during development, little is known about the molecular basis regulating the integrity of the adult BBB.

Methods And Results: Using a mouse model with tamoxifen-inducible endothelial cell-restricted disruption of ctnnb1 (iCKO), we show here that endothelial β-catenin signaling is essential for maintaining BBB integrity and central nervous system homeostasis in adult mice.