Therapeutic potential of : Chemical isolation and validation of ethnomedicinal claims through and assessment of antioxidant and anti-inflammatory properties.

(L.) Ridsdale has been used by different ethnic communities to manage diseased conditions that can be traced to oxidative stress and cellular inflammations but scientific evidences to support the claim are scanty. The objective of this study was to isolate and identify the antioxidants present in the aerial parts of perform their molecular docking against proteins to inspect whether the traditional uses of the plant can be validated by an in-silico approach.

Antioxidant and Antibacterial Activities Evaluation, Phytochemical Characterisation of Rhizome from and Barks from in Nepal.

Ethnomedicinally, more than 2000 plants were found to be used in Nepal. Among them, the red colored rhizome of and the bark of have been used widely to treat muscle fatigue, bone pain, fever, postpartum hemorrhage, and thirst by healers in Kaski and Tanahun districts, Nepal. However, scientific evidence towards their traditional uses is lacking till December, 2023.

Antioxidant, Cytotoxic, and Antibacterial Activities of the Selected Tibetan Formulations Used in Gandaki Province, Nepal.

Materials And Methods: An open-ended and semistructured questionnaire was used for an ethnomedicinal survey of the Tibetan formulations practiced in four Tibetan refugee settlements in Gandaki Province, Nepal. Based on the ethnomedicinal survey data, commonly used nine formulations were selected (Aru-18, Basam, Dadue, Dashel, Mutik-25, Raab Ga Yangzin Tea, Serdok-11, Sugmel-10, and Yungwa-4) to test biological activities. Antioxidant activity was evaluated using the 2,2-diphenyl-1-picryl-hydrazyl (DPPH) radical scavenging method.

Implementation of medicine take-back concept at community level in Nepal: a pilot study.

Background: Most households may have leftover, unwanted, unused and expired (UUE) medicines. The present research aimed to analyze feasibility of implementation of medicine take-back in select communities in Nepal.

Methods: Exploratory (i.

Phytochemical Screening, Free Radical Scavenging and -Amylase Inhibitory Activities of Selected Medicinal Plants from Western Nepal.

More than 700 plants are reported to be used for medicinal purposes in Nepal; however, many of them are not studied for their scientific evidences. The aims of the present study were the estimation of the total phenolic and flavonoid contents, and the evaluation of the free radical scavenging and α-amylase inhibitory activities of five selected medicinal plants from western Nepal: Wall. (Gesneriaceae), Lour.

Chemical Constituents from the Roots, Stems and Leaves of Diplomorpha sikokiana.

Four diarylpentanoids (1-4), two phenylpropanoids (5-6), three biflavonoids (7-9), two lignans (10-11) and a coumarin (12) were isolated from the roots of Diploniorpha sikokiana (Franchet & Savatier) Honda (Family: Thymelaeaceae). Similarly, two phenylpropanoids (5-6), five biflavonoids (7-9, 13, 14), three lignans (11, 15, 16), a flavonoid (17) and two coumarins (12, 18) were isolated from the stems, and five flavonoids (17, 19-22) from the leaves. Among them, 1,5-diphenyl-l-pentanone (1), 1,5-diphenyl-2-penten-l-one (2), 3(S)-hydroxy-1,5-diphenylpentane (3), stelleranol (8), (-)-syringaresinol (10), (-)-pinoresinol 4,4'-di-O-β-D-glucopyranoside (11), apiosylskimmin (12), syringaresinol 4-O-β-D-glucopyranoside (16), quercetin 3-O-α-L-rhamnopyranoside (19), kaempferol 3-0-α-L-rhamnopyranoside (20) and tiliroside (21) were isolated for the first time from D.

Two new diacetylene glycosides: bhutkesoside A and B from the roots of Ligusticopsis wallichiana.

Two new diacetylene glycosides: bhutkesoside A (1) and B (2), along with 10 known compounds, i.e. falcarindiol (3), chlorogenic acid (4), 5-O-p-coumaroyl-quinic acid (5), 3,5-di-O-caffeoyl-quinic acid (6), 4-hydroxy-7-methoxy-phenylethanol (7), ferulic acid (8), dehydrodiconiferyl alcohol-4-O-β-d-glucopyranoside (9), 5,7-dihydroxy-2-methylchromone-7-O-rutinoside (10), schumanniofioside B (11) and marmesinin (12) were isolated from the roots of Ligusticopsis wallichiana (DC) Pimenov & Kljuykov (Apiaceae), commonly known as 'Bhutkesh' in Nepal.

Dhasingreoside: new flavonoid from the stems and leaves of Gaultheria fragrantissima.

A new flavonoid, dhasingreoside (1) and seven known compounds, quercetin 3-O-β-D-galacturonopyranoside (2), quercetin 3-O-β-D-galactopyranoside (3), quercetin 3-O-β-D-glucuronopyranoside (4), quercetin 3-O-α-L-rhamnopyranoside (5), (-)-epicatechin (6), salicylic acid (7) and gaultherin (8), have been isolated from the shade-dried stems and leaves of Gaultheria fragrantissima, commonly known as 'Dhasingre' in Nepal. The structures were elucidated on the basis of physical, chemical and spectroscopic methods. Among known compounds, five compounds (3-6 and 8) were isolated for the first time from G.

Bijayasaline: a new C-glucosyl-alpha-hydroxydihydrochalcone from the heartwood of Bijayasal (Pterocarpus marsupium).

A new C-glucosyl-alpha-hydroxydihydrochalcone derivative, (aS)-3'-C-ff-glucopyranosyl-a,3,4,2'4'-pentahydroxydihydrochalcone, named as bijayasaline (1) was isolated from the heartwood of Bijayasal (Pterocarpus marsupium) and characterized on the basis of NMR and circular dichroism (CD) spectral data. Bijayasaline (1) showed potent DPPH free radical scavenging activity.

Phenolic compounds from the flowers of Nepalese medicinal plant Aconogonon molle and their DPPH free radical-scavenging activities.

Eleven phenolic compounds, quercetin (1), quercetin 3-O-β-d-galactopyranoside (2), quercetin 3-O-(6″-O-galloyl)-β-d-galactopyranoside (3), quercetin 3-O-(6″-O-caffeoyl)-β-d-galactopyranoside (4), quercetin 3-O-β-d-glucopyranoside (5), rutin (6) quercetin 3-O-α-l-arabinopyranoside (7), quercetin 3-O-α-l-arabinofuranoside (8), protocatechulic acid (9), gallic acid (10) and chlorogenic acid (11), were isolated from the flowers of Aconogonon molle, a Nepalese medicinal plant. Structures of these compounds were elucidated on the basis of spectroscopic methods. All these compounds were isolated for the first time from flowers, and five compounds (4, 5, 8, 9 and 11) were isolated for the first time from A.

Thotneosides A, B and C: potent antioxidants from nepalese crude drug, leaves of Aconogonon molle.

Three new glycosides: thotneoside A (quercetin 3-O-(6″-O-phenylacetyl)-β-D-galactopyranoside) (1), thotneoside B (quercetin 3-O-(6″-O-phenylacetyl)-β-D-glucopyranoside) (2) and thotneoside C (3-methyl-2-butenoic acid 1-O-β-D-glucopyranoside) (3), together with nine known compounds; quercetin (4), quercetin 3-O-β-D-galactopyranoside (5), quercetin 3-O-(6″-O-galloyl)-β-D-galactopyranoside (6), quercetin 3-O-β-D-galacturonopyranoside (7), quercetin 3-O-β-D-glucuronopyranoside (8), quercetin 3-O-α-L-rhamnopyranoside (9), rutin (10), quercetin 3-O-α-L-arabinopyranoside (11) and 2,4,6-trihydroxyacetophenone 2-O-β-D-glucopyranoside (12) have been isolated from the shade dried leaves of Aconogonon molle, commonly known as "Thotne″ in Nepal. The structures were elucidated on the basis of chemical and spectroscopic methods. All of these compounds were isolated for the first time from A.