Publications by authors named "Khatkov I"
Importance: Postoperative pancreatic fistulas (POPF) are the biggest contributor to surgical morbidity and mortality after pancreatoduodenectomy. The impact of POPF could be influenced by the surgical approach.
Objective: To assess the clinical impact of POPF in patients undergoing minimally invasive pancreatoduodenectomy (MIPD) and open pancreatoduodenectomy (OPD).
Background: Pancreatoduodenectomy in elderly patients may be associated with increased postoperative mortality, but studies in minimally invasive pancreatoduodenectomy (MIPD) are scarce.
Methods: International multicenter retrospective study including patients aged >60 years undergoing MIPD (robot-assisted and laparoscopic) and open pancreatoduodenectomy (OPD), were categorized by age: 60-69, 70-79, and 80+ years. In each category, propensity score matching (PSM) was performed (1:1 ratio) between MIPD and OPD.
The gut microbiota's pivotal role in human health is increasingly evident, particularly in chronic conditions like obesity, diabetes, and inflammatory diseases. This intricate symbiotic relationship influences metabolic balance and immune responses. Notably, gut microbial dysbiosis is linked to obesity's metabolic disruption and chronic low-grade inflammation.
View Article and Find Full Text PDF[The Russian consensus on the treatment of intrahepatic cholangiocarcinoma].
Khirurgiia (Mosk)
October 2024
The Russian consensus on the treatment of intrahepatic cholangiocarcinoma was prepared by the group of experts consisting of surgeons, interventional radiologists, radiation therapists and oncologists. The purposes of this consensus are clarification and consolidation of opinions of multidisciplinary team on the following issues of management of patients with intrahepatic cholangiocarcinoma: indications for surgical treatment, features of therapeutic tactics for mechanical jaundice, technical aspects of liver resection, prevention of post-resection liver failure, indications for liver resection using transplantation technologies, laparoscopic and robot-assisted liver resection, perioperative systemic chemotherapy, local non-resection/non-radiotherapy methods of treatment, radiotherapy, follow-up and choice of treatment for recurrence.
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- The study aimed to assess how post-processing of CT results can help in non-invasively diagnosing pancreatic fibrosis (PF) in patients with chronic pancreatitis and pancreatic cancer.
- It involved 165 patients, where contrast ratios of pancreatic tissues were measured, and the degree of PF was evaluated using established scales.
- Results showed that higher contrast ratios correlated with more severe PF and that signs of inflammation in pancreatic tissues also indicated increased contrast ratios, suggesting a link between CT results and morphological signs of PF.
Article Synopsis
- - Myelodysplastic syndrome (MDS) is a disease from blood stem cells that leads to ineffective blood cell production and a higher risk of developing acute myeloid leukemia (AML).
- - MDS arises from various genetic mutations, resulting in diverse genetic profiles among patients, and specific genetic changes have been linked to its development.
- - The article discusses a clinical case where MDS progressed to AML, highlighting two cell lines with distinct characteristics and two specific mutations in the relevant gene.
Article Synopsis
- The extraocular muscles (EOMs) are distinct from other skeletal muscles due to their remarkable resistance to muscular dystrophies and aging, making them unique in their ability to maintain function.
- EOMs have complex structural properties, including diverse fiber types and specialized innervation, which contribute to their ability to execute rapid and precise eye movements.
- Research into EOMs may provide valuable insights for developing treatments for other skeletal muscle disorders, as understanding their cellular and molecular resilience could inform therapeutic strategies.
Article Synopsis
- - The study compares the outcomes of robot-assisted and laparoscopic pancreatoduodenectomy across 50 European centers, focusing on major morbidity and mortality rates among patients from 2009 to 2020.
- - The results show no significant differences in major morbidity and 30-day mortality rates between the two surgical methods, but robot-assisted surgery had lower conversion rates and better lymph node retrieval.
- - Laparoscopic pancreatoduodenectomy had advantages like shorter operation times and lower rates of postoperative pancreatic complications, suggesting it may be the preferable approach in certain aspects.
Article Synopsis
- International guidelines suggest that monitoring minimally invasive pancreatic surgery (MIPS) is important, but there is a lack of data, particularly on minimally invasive distal pancreatectomy (MIDP).
- This study analyzed data from 1672 patients in 83 European centers to compare robot-assisted distal pancreatectomy (RDP) and laparoscopic distal pancreatectomy (LDP), focusing on intraoperative events, major morbidity, and mortality.
- Findings showed RDP had fewer intraoperative complications but longer surgery times compared to LDP; both procedures had low mortality rates, with LDP still being the more common approach despite the rising use of RDP.
Article Synopsis
- The REDISCOVER consensus conference focused on creating guidelines for the perioperative care of patients with borderline-resectable and locally advanced pancreatic ductal adenocarcinoma (PDAC).
- Using a structured methodology and expert consensus, the conference developed 34 recommendations on various aspects of surgical care, patient selection, and management of pancreatic cancer.
- Despite the low evidence quality for most recommendations, participants highlighted the importance of establishing an international registry to enhance understanding and care for this patient group.
Article Synopsis
- There is a lack of international studies on the outcomes of minimally invasive pancreatoduodenectomy (MIPD), prompting the establishment of the European Registry for Minimally Invasive Pancreatic Surgery (E-MIPS) to monitor these procedures in Europe.
- An analysis of 1,336 patients from 45 centers across 14 European countries indicated significant outcomes, including a major morbidity rate of 41.2% and a 30-day/in-hospital mortality rate of 4.5%.
- Findings revealed that robot-assisted MIPD (R-MIPD) is becoming more popular than laparoscopic MIPD (L-MIPD), with better outcomes in terms of major morbidity and lower rates of complications when performed
Cancer is a major global public health challenge, affecting both quality of life and mortality. Recent advances in genetic research have uncovered hereditary cancer syndromes (HCS) that predispose individuals to malignant neoplasms. While traditional single-gene testing has focused on high-penetrance genes, the past decade has seen a shift toward multigene panels, which facilitate the analysis of multiple genes associated with specific HCS.
View Article and Find Full Text PDFA clinical case of a 71-year-old patient with intraductal papillary mucinous neoplasia (IPMN) is presented. The diagnosis was established using endoscopic retrograde cholangiopancreatography, magnetic resonance imaging, computed tomography. Asymptomatic course, absence of pain syndrome, obstruction, exocrine and endocrine pancreatic failure, relatively satisfactory general health, but the presence of structural changes: an increase cyst in the head of the pancreas measuring 27×23 mm, expansion of the main pancreatic duct up to 13 mm raised doubts about the choice of treatment tactics, the need for surgical intervention.
View Article and Find Full Text PDFMalignant neoplasms, including pancreatic cancer and melanoma, are major global health challenges. This study investigates melanoma pancreatic syndrome, a rare hereditary tumor syndrome associated with gene mutations. mutations contribute to a lifetime risk of melanoma ranging from 28% to 67%.
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- - Minimally invasive pancreatoduodenectomy (MIPD) is seen as a less harmful alternative to traditional open pancreatoduodenectomy (OPD), but its safety and recovery time compared to OPD require further investigation through large-scale trials.
- - The DIPLOMA-2 trial is a major international study involving 288 patients across 14 high-volume centers in Europe, evaluating MIPD against OPD, with a focus on overall complications and functional recovery time.
- - The trial will measure outcomes using the Comprehensive Complication Index (CCI®) and assess recovery times and other operative results to determine if MIPD offers significant benefits over OPD.
Article Synopsis
- The study investigates the relevance of biopsies from the incisura angularis in determining the risk of gastric cancer in patients with chronic gastritis using the OLGA system for assessment.
- A total of 718 patients were examined, aged 20 to 84, and categorized based on the presence of autoimmune gastritis markers, resulting in three distinct patient groups.
- Results showed that grade II inflammatory changes were prevalent (72.3%) across all groups, with severe chronic gastritis activity most common in patients with non-autoimmune gastritis, and these findings remained consistent even when excluding the incisura angularis biopsy.
Background: Evidence on the value of minimally invasive pancreatic surgery (MIPS) has been increasing but it is unclear how this has influenced the view of pancreatic surgeons on MIPS.
Methods: An anonymous survey was sent to members of eight international Hepato-Pancreato-Biliary Associations. Outcomes were compared with the 2016 international survey.
Gastric cancer is a major challenge in modern oncology due to its high detection rate and prevalence. While sporadic cases make up the majority of gastric cancer, hereditary gastric cancer is caused by germline mutations in several genes linked to different syndromes. Thus, identifying hereditary forms of gastric cancer is considered crucial globally.
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- Pancreatic fibrosis (PF) is key in chronic pancreatitis and this study examined its relationship with various factors in pancreatic specimens from 74 patients.
- Significant differences were found in imaging parameters (like unenhanced pancreas density and contrast enhancement ratio) based on fibrosis grades and inflammation indicators in the tissue.
- Blood levels of fibronectin and hyaluronic acid showed correlations with different aspects of fibrosis, suggesting that these and imaging parameters could aid in non-invasive diagnosis of PF.
Objective: To develop and update evidence-based and consensus-based guidelines on laparoscopic and robotic pancreatic surgery.
Summary Background Data: Minimally invasive pancreatic surgery (MIPS), including laparoscopic and robotic surgery, is complex and technically demanding. Minimizing the risk for patients requires stringent, evidence-based guidelines.
is one of the most common cause of human infections. Infected patients develop chronic active gastritis in all cases, which can lead to peptic ulcer, atrophic gastritis, gastric cancer and gastric MALT-lymphoma. The prevalence of infection in the population has regional characteristics and can reach 80%.
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- A study was conducted to create a standardized set of quality performance indicators (QPI) for hepatopancreaticobiliary (HPB) surgical procedures worldwide.
- The research involved a thorough literature review and feedback from members of the International Hepatopancreaticobiliary Association (IHPBA) via a modified Delphi process.
- The finalized QPI consists of seven core indicators applicable to multiple HPB surgeries, along with additional specific indicators for procedures like pancreatectomy, hepatectomy, and cholecystectomy, which were approved by over 100 IHPBA members globally.*
More than 275 million people in the world are carriers of a heterozygous mutation of the gene, associated with cystic fibrosis, the most common autosomal recessive disease among Caucasians. Some recent studies assessed the association between carriers of variants and some pathologies, including cancer risk. The aim of this study is to analyze the landscape of germline pathogenic heterozygous variants in patients with diagnosed malignant neoplasms.
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