Synthesis, characterization, cytotoxicity and DNA/BSA binding of two amino acid palladium(II) complexes derived from alanine and valine.

Two novel palladium(II)-amino acid complexes, [Pd(Ala)]·HO () and [Pd(Val)].HO () (Ala = alanine; Val = valine) were synthesized and characterized through FTIR, UV/Vis, H-NMR spectroscopies, CHN analysis, X-ray crystallography and molar conductivity measurement. Furthermore, cytotoxicity of Pd(II) complexes against human leukemia cancer cell line, MOLT4 showed promising cancer cell death (CC = 0.

A new palladium-based antiproliferative agent: synthesis, characterization, computational calculations, cytotoxicity, and DNA binding properties.

A new palladium(II) complex entitled [Pd(phendione)(8Q)]NO, (PdPQ), where phendione is N,N-donor heterocyclic 1,10-phenanthroline-5,6-dion and 8Q is 8-hydroxyquinolinate, has been synthesized and then characterized by molar conductivity, CHN analysis and spectral data (UV-Vis, FT-IR, NMR). DFT/ TDDFT procedures were also performed to determine the electronic structure and the nature of the electronic transitions of PdPQ. Moreover, the affinity and binding properties of DNA to the desired complex have been studied in details using electronic absorption, fluorescence, circular dichroism spectroscopies, and viscosity measurement in combination with molecular docking technique.

Multi-stage screening to predict the specific anticancer activity of Ni(II) mixed-ligand complex on gastric cancer cells; biological activity, FTIR spectrum, DNA binding behavior and simulation studies.

The anticancer activity of a transition metal complex with [Ni(L)L]HO (where L and L were acetylacetonato (acac) and 2-aminopyridine (2-ampy), respectively) was evaluated in MKN45 cell line. Methyl thiazolyl tetrazolium (MTT) assay was performed to assess the antitumor capacity of the Ni(II) complex against gastric cancer cell line MKN45. The complexexhibited high in vitro antitumor activity against MKN45 cells with ICvalues of 1.

Interaction of bis(alkylamine)dichloropalladium(II) complexes with CT-DNA and BSA; their synthesis, characterization, antitumor, and antibacterial evaluations.

A series of five new and analogous palladium(II) alkylamine complexes of cisplatin derivatives such as cis-[Pd(alkyl-am)Cl], where alkyl-am is Ethyl-, Propyl-, Butyl-, Hexyl-, and Octyl-amine, have been prepared. They have been characterized by physicochemical methods such as FT-IR, H-NMR, UV-Vis, conductivity measurements and elemental analysis. These synthesized metal complexes were screened for their antitumor activity against human MOLT-4 cells.

A novel cadmium(II) complex of bipyridine derivative: synthesis, X-ray crystal structure, DNA-binding and antibacterial activities.

A mononuclear cadmium(II) complex of formula [Cd(5,5'-dmbipy)(OAc)]·2HO (5,5'-dmbipy = 5,5'-dimethyl-2,2'-bipyridine and OAc = acetato ligand) has been synthesized and characterized by FT-IR, UV-Vis, H-NMR, elemental analysis and single-crystal X-ray structure analysis. The molecular structure of the complex shows a distorted tetragonal antiprism CdNO coordination geometry around the cadmium atom, resulting in coordination by four nitrogen atoms from two 5,5'-dmbipy ligands and four oxygen atoms from two acetate anions. The interaction of this complex to FS-DNA (fish sperm DNA) has also been studied by electronic absorption, fluorescence and gel electrophoresis techniques.

Ordering selected Zn(II), Cu(II), Pd(II) and Co(III) complex compounds: their separately and combinedly antibacterial therapy and DNA-binding studies.

In this study, four Co(III)-, Cu(II)-, Zn(II)- and Pd(II)-based potent antibacterial complexes of formula K[Co(ox)]·3HO (), [Cu(phen)Cl]Cl·6.5HO (), [Zn(phen)]Cl () and [Pd(phen)](NO) () (where ox is oxalato and phen is 1,10-phenanthroline) were synthesized. They were characterized by elemental analysis, molar conductivity measurements, UV-vis, Fourier transform infrared (FT-IR) and proton nuclear magnetic resonance (H-NMR) techniques.

Nonionic but water soluble, [Glycine-Pd-Alanine] and [Glycine-Pd-Valine] complexes. Their synthesis, characterization, antitumor activities and rich DNA/HSA interaction studies.

Two novel, neutral and water soluble Pd(II) complexes of formula [Pd(Gly)(Ala)] () and [Pd(Gly)(Val)] () (Gly, Ala, and Val are anionic forms of glycine, alanine, and valine amino acids, respectively) have been synthesized and characterized by FT-IR, UV-Vis, H-NMR, elemental analysis, and molar conductivity measurement. The data revealed that each amino acid binds to Pd(II) through the nitrogen of -NH and the oxygen of -COO groups and acts as a bidentate chelate. These complexes have been assayed against leukemia cells (K) using MTT method.

Antiproliferative effects of copper(II)-polypyridyl complexes in breast cancer cells through inducing apoptosis.

Although cisplatin has been used for decades to treat human cancer, some toxic side effects and resistance are observed. Previous investigations have suggested copper complexes as a novel class of tumor-cell apoptosis inducers. The present study aimed to evaluate the anti-breast cancer activities of two polypyridyl-based copper(II) complexes, [Cu(tpy)(dppz)](NO3)2 (1) and [Cu(tptz)2](NO3)2 (2) (tpy = 2,2':6',2″-terpyridine, dppz = dipyrido[3,2-a:2',3'-c]phenazine, tptz = 2,4,6-tris(2-pyridyl)-1,3,5-triazine), using human breast adenocarcinoma cell line (MCF-7).

Computational and experimental study on the electrocatalytic reduction of CO2 to CO by a new mononuclear ruthenium(ii) complex.

A new mononuclear ruthenium(ii) complex, trans-[Ru(dmb)2(Cl)(EtOH)](PF6) (dmb = 4,4'-dimethyl-2,2'-bipyridine), has been prepared and characterized by elemental analysis, spectroscopic techniques and single crystal X-ray structure determination. The complex was studied as a precatalyst for the electrocatalytic reduction of CO2 to CO in an acetonitrile solution by cyclic voltammetry (CV). The catalytic mechanism was investigated by means of quantum chemical calculations to gain deeper insight into the process of CO2 reduction.