Development of surface ionization mass spectrometry for detection of stimulants in human urine.

This paper demonstrates direct detection of stimulants such as amphetamine, methamphetamine and cocaine spiked with untreated urine and a real world sample using surface ionization mass spectrometry. Spiked samples were analyzed without preliminary chromatographic separation and extraction procedure using the developed method. Moreover, in order to check the analytical capabilities of the method non-extracted real world sample was analyzed.

Remote sampling mass spectrometry for dry samples: Sheath-flow probe electrospray ionization (PESI) using a gel-loading tip inserted with an acupuncture needle.

Rationale: Probe electrospray ionization (PESI) is only applicable to liquid or wet samples. In this study, a sheath-flow PESI method for remote sampling mass spectrometry that can be applied to dry samples was developed.

Methods: An acupuncture needle (0.