Poikilocytosis in the acne vulgaris comorbidity with demodicosis and functional gallbladder disorder.

Objective: The aim of the study was to evaluate the role of poikilocytosis in the acne vulgaris comorbidity with demodicosis and functional gallbladder disorder.

Patients And Methods: Materials and methods: The study included 140 people with a diagnosis of moderate acne: group 1 - patients with AV, group 2 - patients with AV + Demodicosis, group3- AV + Demodicosis + functional gallbladder disorder (FGD). Biochemical analysis of lipid profile and liver enzymes, bilirubin was performed with semi-automatic analyzer HUMALYZER 3000.

[CHROMOSOMAL DISORDERS IN WORKERS OF CHEMICALLY HAZARDOUS ENTERPRISES WITH THE DIFFERENT HEALTH STATUS].

Unlabelled: OBJECTIVES. Chromosomal aberrations (CAs) are the one of the most sensitive biomarikers of biological effects from the hazardous environmental exposure. In this relation the comparison of cytogenetical indices in persons, exposed to the complex of factors of chemically hazard enterprises, with the presence of occupationally caused diseases seems to be very perspective for the understanding of the role of the contribution of genotoxical impact of occupational factors into staff morbidity.

[Using modern information technology in the practice of the sanitary-epidemiological surveiliance during the XXII Olympic Winter Games and XI Paralympic Winter Games in Sochi].

To improve the sanitary and epidemiological surveillance at the Olympic Games has developed a system of GIS for monitoring objects and situations in the region of Sochi. The system is based on software package ArcGIS, version 10.2 server, with Web-java.

[Epidemiological risk of introduction of dangerous and exotic infectious diseases on the territory of the XXII Olympic Winter Games and XI Paralympic Winter Games 2014 in Sochi].

To assess the epidemiological risk of introduction of serious infectious diseases in the pre-Olympic period defined list of dangerous and exotic infections and held assessment of potential danger threatening. Initial external information to assess the potential risk of skidding were reports, forecasts, posted on the official websites. The risk of skidding and epidemiological complications conditionally designated as high, moderate and minimal risk importation of measles virus-Rate was considered as high.

[Cytogenetical alterations in the workers of higher chemical hazard enterprises in accordance with duration of the employment period].

Cytogenetical examination was performed in 135 workers of higher chemical hazard enterprises with the duration of the employment period from 1 to 23 years. Weak, but statistically significant correlations were observed between indices: the total rate of chromosome aberrations (CA) (Tau = 0.14, p < 0.

[Smoking as an additional risk factor for the staff of chemically hazardous production facilities].

One of the factors that increase the risk of genotoxic effects in the staff of chemically hazardous production facilities is smoking. There was performed the cytogenetic study in 104 males working with highly toxic chemicals, 71 people out of which were smokers and 33--non-smokers. No statistically significant differences were revealed between groups of smokers and nonsmokers.

[Cytogenetic examination of the workers of higher chemical hazard enterprises and the population of the nearby territories].

Cytogenetical examination was made in 49 workers of higher chemical hazard enterprises and 26 dwellers from industrial communities, who were engaged in enterprise security. Analysis of chromosome aberrations (CA) in the examined groups revealed a 1.8-fold increase in total CA rates in the industrial community dwellers securing the enterprise as compared to the controls mainly due to the rise in the rate of single fragments.

[Clinical studies of vaccine TEOVac under the conditions of remote revaccination].

In the clinical trials of vaccine TEOVac in lower and reglamented doses under the conditions of remote vaccination, carried out on 11 volunteers, local reactions in the form of hyperemia, gingival edema (1 vaccinee), faucial hyperemia, enlargement of submaxillary lymph nodes (2 vaccinees) were registered in some of the vaccines; in one vaccinee systemic postvaccinal reaction of medium gravity was observed. Revaccination produced no negative effect on the hematological and biochemical characteristics of the blood, as well as on the urine characteristics. The study of the sensitizing vaccine to the antigens of the accumulation substrate (chick embryo), as well as its influence on the development of autoimmune reactions, revealed the absence of the allergic action of the preparation and its influence on autoimmune processes in the vaccines.

Thymic epithelial cells induce Fas-independent activation apoptosis of thymocytes.

Co-cultivation of human thymocytes with homologous thymic epithelial cells (TEC) resulted in apoptosis of thymocytes and increase of CD25 expression. TEC supernatant also induced these effects. Fraction of apoptotic cells was enriched by CD69+ cells but not by CD95+ cells.

Cytogenetic investigation of occupationally irradiated persons a long time after exposure.

Chromosomal analyses were performed in blood lymphocytes of 33 persons previously occupationally exposed to ionizing radiation. An increased frequency of chromosome aberrations, mainly dicentrics, a long time, up to 47 years after exposure, suggests that it is possible to use the method of unstable aberration analysis for assessment of previous radiation exposure. The enhanced yield of dicentrics was observed in persons who may have received irradiations above permitted limits.

Cytogenetic investigation of thallium-poisoned people: pilot study.

Thirteen blood samples of thallium-poisoned people were cytogenetically investigated. The thallium concentration in blood varied from 25 to 2700 microg/L. The mean frequency of chromosomal aberrations in the poisoned group significantly exceeded our control level (7.

[The results of a clinical study of the preparation Fastum gel in patients with certain forms of occupational diseases].

The article presents a positive appraisal of efficacy of local application of the drug Fastum-gel (ketoprophen) in a combined treatment of occupational diseases of the locomotor and neuromuscular apparatus. A maximum therapeutic effect was noted in treatment of patients with above medical problems.

Increased level of chromosomal aberrations in lymphocytes of Chernobyl liquidators 6-10 years after the accident.

Chromosomal aberrations (CA) were used to investigate the level of cytogenetical damage in peripheral blood lymphocytes from the liquidators in a remote period (6-10 years) after the Chernobyl accident. There was a significantly higher frequency of chromosomal radiation markers (dicentrics and rings) in the peripheral lymphocytes of the liquidators than in the control subjects. No differences between these groups were demonstrated by the micronucleus (MN) test.

Hormone Production by Epithelial Cells of Human Thymus in vitro.

The conditions of hormone production by human thymic stromal cell line were studied. Human thymic stromal cells did not produce any hormones in 5-day monoculture. Co-cultivation of these cells with human thymocytes induced alpha1-thymosin and thymulin production increased to 4-5 days of co-cultivation.

[Functionally active T-cells and T-lymphocyte precursors in the thymus of newborn mice irradiated in the intrauterine period of development].

Mice were irradiated in dose of 2 Gy in 14 or 17 days of gestation. Irradiation retarded the increase of cell number in developing thymuses but in the day of birth the number of thymocytes was normalized. In normal development SC-1+ cells (T cell precursors) disappeared from the thymus immediately before the birth.

[Effect of ionizing radiation on the thymus stroma of embryos and newborn mice].

The lobes of thymus of newborn mice irradiated on 17 day of embryonic life or on 1 day after the birth were transplanted under the renal capsule of adult mice. The recipients were thymectomized, lethally irradiated and reconstituted by syngeneic bone marrow cells treated by monoclonal anti-Thy-1-antibody and complement 1 month before the transplantation of thymus. Colonization of the thymus transplants, number and functional activity of T cells in peripheral lymphoid organs of recipients were measured 30 day after the transplantation of thymus.

[A cytogenetic study of the human chorion for the purpose of the prenatal diagnosis of hereditary diseases].

Cytogenetical investigation of 50 diagnostic chorionic villus samples from women with a high risk of giving birth to babies with chromosomal and genic pathology, and of 128 chorionic samples obtained from medical abortions, both on the 8-12th weeks of gestation was performed by means of original direct chromosomal analysis. Chromosomal anomalies were found in 6 cases of diagnostic chorion biopsies (12%) and in 4 cases (3%) of medical abortions. The former group included 5 embryos with autosomal trisomy (4--Ts21 and 1--Ts13) and one embryo with monosomy 18.

[Hygienic bases, goals and structure of data banks on hazards of polymers].

The first phase of data bank of hazard (DBH) of polymers has been developed and put into operation on the basis of CM-computers. DBH is a factographical computer-based system of data collection, storage and processing aimed at complex assessment of material and substance hazard. Systems approach to the analysis of material's characteristics serves as a methodological basis.