Staging Heart Failure with Preserved Ejection Fraction by Assessing Cardiac Chamber Involvement.

The management of heart failure with preserved ejection fraction (HFpEF) remains largely unresolved due to our limited understanding of the underlying mechanisms of the pathology and the challenges in accurately phenotyping this heterogeneous syndrome. A paradigm shift is required to personalise care and unify our approaches to HFpEF patients for future clinical trials. Accordingly, we propose a staging classification for HFpEF based on the identification of the involved cardiac chambers by echocardiography.

Antimutagenic Activity as a Criterion of Potential Probiotic Properties.

The antimutagenic activity of probiotic strains has been reported over several decades of studying the effects of probiotics. However, this activity is rarely considered an important criterion when choosing strains to produce probiotic preparations and functional food. Meanwhile, the association of antimutagenic activity with the prevention of oncological diseases, as well as with a decrease in the spread of resistant forms in the microbiota, indicates its importance for the selection of probiotics.

Comparison of Fragments in Human Hemostatic Proteins That Mimics Fragments in Proteins of A/H1N1 Viruses and Coronaviruses.

: To compare the repertoire of proteins of the human hemostatic system and fragments mimicking these proteins in the proteins of influenza A/H1N1 viruses and coronaviruses. . Influenza viruses A/H1N1 (A/Brevig Mission/1/18), A/St.

Biodiversity of Cav. in rice-growing regions of the south of Russia using PCR method.

The purpose of this research by the way of investigating the molecular genetic structure of a highly variable fungal phytopathogen Cav., to determine effective genes for the development of a strategy for immunogenetic protection against rice blast in conditions of epiphytotic development of the disease in the south of Russia, which would combine high efficacy with both environmental friendliness and resource and energy saving, to ensure country's food security. The knowledge of local pathotype diversity of Cav.

[Brain plasticity: limitations and possibilities].

Biological limitations related to the brain regeneration and stem cells transplantation as well as the factors influencing the brain plasticity following the brain injury, including epigenetic regulatory mechanisms, are presented. Non-invasive transcranial microelectrostimulation is considered as a perspective method of polysystemic influence on endogenic mechanisms of brain recovery.

[Spread of nosocomial infection in obstetric hospitals].

The paper highlights the topical problems of nosocomial infection in the practice of obstetrics and perinatology. It systematizes procedures for controlling the occurrence of nosocomial infection and preventing its spread, such as identification of risk groups and risk factors and prerequisites for complications of epidemiological surveillance, as well as specific diagnosis in pregnant women. Group B streptococcus, one of the major pathogens of nosocomial infection, is described.

[Nosocomial obstetric infections: Yesterday, today, tomorrow].

Antibiotic resistance of microorganisms is one of the most acute problems of modern obstetrics. The paper analyzes current antibiotic resistance. It considers the mechanisms of its formation and ways to overcome the resistance.

[The role of a lysine residue in the antioxidant and dna-protective activity of oligopeptides].

Oligopeptides present in the living cell were found to have antioxidative activity and to be involved in the regulation of antioxidant balance by interaction with the redox-dependent cellular signaling cascades. Experiments on animal models have shown that the introduction of oligopeptides causes geroprotective and adaptogenic effects. In the present work, we investigate the biological action of a number of synthetic oligopeptides using bacterial biosensors.

[Creation of Blast Disease-Resistant Rice Sorts with Modern DNA-Markers].

Based on modern technologies of molecular DNA-markers, blast disease-resistance genes (Pi-ta, Pi-b, Pi-1, Pi-2, and Pi-33) were introgressed and pyramided into domestic rice varieties to give them long-term disease resistance. For that purpose, this case study uses SSR-markers closely linked to these genes, as well as intragenic markers of genes Pi-ta and Pi-b. Multiplex PCR systems were created for simultaneous identification of two resistance genes in the hybrid progeny for the following combinations: Pi-1 + Pi-2, Pi-ta + Pi-b, Pi-ta + Pi-33.

[Arterial hypertension: an expanding pathogenic continuum and therapeutic limitations].

The paper considers the role of the immune system, endoplasmic network stress, metabolic dysregulation, and epigenetic mechanisms in the pathogenesis of essential hypertension, as well as the limited possibilities of therapy with existing antihypertensive agents.

[Heart failure in cardiorenal syndromes].

This review considers the classification of cardiorenal syndromes (CRS), the pathogenesis of heart failure, and a search for therapeutic targets for its treatment, biomarkers for heart and kidney failure, difficulties in therapy and reversion of the pathogenetic continuum of CRS, and promises for the use of some new technologies to treat this condition.

[Heart failure: the pathogenetic continuum and biomarkers].

Molecular aspects of pathogenesis of cardiac failure touching on transmission of pathological signals through the transduction system, involvement of mechanisms of transcriptional reprogramming and metabolic changes in the myocardium, as well as processes of aging and inflammation in the pathogenetic continuum are considered in this paper. Data on markers of early diagnosis, prognosis and progression of heart failure and perspectives of discovery of its pathogenesis within framework of developing system biology integrating analysis of multiple different in their nature biomarkers are also presented.

[The influence of prolonged transthoracic microelectrostimulation on the course of myocardial infarction].

The subjects of the study were patients with acute myocardial infarction, who underwent prolonged transthoracic microelecrostimulation. The procedure had certain immediate effects, such as antinociceptive, anxiolytic, hypotensive, and somnific effect, lead to positive emotional shifts and substantial decrease of the degree of circulatory insufficiency, and to positive ECG dynamics. It also had long-time effects, such as positive myocardial remodeling, manifesting in the stabilization of end diastolic volume, lowering of end systolic volume and thus increase of ejection fraction, according to EchoCG results.

[Treatment of infantile cerebral paralysis using transcraniovertebral microelectric stimulation].

A new method of therapy of children with cerebral palsy (CP) has been elaborated. Transitory consequent action of weak bipolar low-frequency current (30-100 mcA, 2-10 Hz) on different levels of motor activity regulation (brain and spinal cord, effectory organs) resulted in a stable correction of both motor and other types of disorders in CP patients. Therapeutic course included 2-8 procedures, 1-2 weekly, their duration 3-5 minutes.