A new cytotoxic cardenolide from the roots of .

Bioactivity-guided isolation of the CHCl-soluble fraction of the roots of was carried out to obtain a new cardenolide glycoside, caloside G. Its absolute structure was elucidated based on NMR and ECD spectroscopic data interpretation. Caloside G showed noteworthy cytotoxicity against the PANC-1 human pancreatic and HeLa human cervical carcinoma cell lines, with the submicromolar IC values of 0.

Calosides A-F, Cardenolides from and Their Cytotoxic Activity.

Phytochemical analysis of the roots of led to the isolation of six new cardenolide glycosides, calosides A-F (-), and five known cardenolides (-). The structures of - were elucidated based on NMR and ECD spectroscopic data interpretation. Caloside D () is the first naturally occurring example of a cardenolide containing a C-8/C-19 oxygen bridge.

Phytochemical and cytotoxic studies on the leaves of Calotropis gigantea.

A new lignan, 9'-methoxypinoresinol (1), and two new glycosylated 5-hydroxymethylfurfurals, calofurfuralside A (2), and calofurfuralside B (3), together with nine known compounds (4-12) have been isolated from the active fractions, CHCl (IC, 0.32μgmL) and EtOAc (IC, 0.55μgmL) fractions of the leaves of Calotropis gigantea.

Geranyl dihydrochalcones from Artocarpus altilis and their antiausteric activity.

Human pancreatic cancer cell lines have remarkable tolerance to nutrition starvation, which enables them to survive under a tumor microenvironment. The search for agents that preferentially inhibit the survival of cancer cells under low nutrient conditions is a novel antiausterity strategy in anticancer drug discovery. In this study, the methanolic extract of the leaves of Artocarpus altilis showed 100 % preferential cytotoxicity against PANC-1 human pancreatic cancer cells under nutrient-deprived conditions at a concentration of 50 µg/mL.