INFORMATIONAL STRESS AS A DEPRESSION INDUCING FACTOR (EXPERIMENTAL STUDY).

Chronic psychogenic stress represents the major initiating agent of psychoneural diseases including depression. We used informational stress model for the purpose of modelling chronic psychogenic stress and depression. The aim of the research was to study behavior of dominant and submissive rats at different stages of informational stress and during depression state.

BEHAVIORAL CHARACTERISTICS OF RATS ON VARIOUS HIERARCHICAL LEVEL CAUSED BY ACUTE INFORMATIONAL STRESS.

The aim of our research was to study behavioral indices of rats standing on various hierarchical level in the conditions of acute informational stress as well as their resistance to stress taking into account their social status. The Animal's behavior has been studied in conflict and agonist conditions against the background of high food and thirst motivation. After determination of hierarchical relations the stressing procedure of two active avoidance reactions was performed simultaneously during one trial (14 days).

[Chronic psychogenic stress as a factor of formation depressive behavior in rats].

The problem of adequate animal model of depression still remains. In our experiments depression-like condition on white rats were reached by the chronic stressors of psychogenic nature. Stress was carried out in a modified shuttle chamber of active avoidance.

Association between tree pollen counts and asthma ED visits in a high-density urban center.

Background: Asthma exacerbation patterns are cyclic in nature and often correlate with air particle concentrations.

Objective: To examine the relationship between asthma-related emergency department (ED) visits and outdoor air quality for pediatric and adult patients in a high asthma prevalence area, the New York City borough of the Bronx.

Methods: Numbers of daily asthma-related adult and pediatric ED visits during one complete year (1999) were obtained from the seven major Bronx hospitals.

[Study of self-regulating behavior at different stages of psychogenic stress before the formation of depressive-like state in rats].

During last decades abnormalities of neuro-psychic sphere have become a topic of great interest. Among them an important place takes depression. Psychogenic factors are commonly the most frequent cause of depressive condition, and till now the study of so-called transitional period (from the beginning of stressor action till the formation of depressive state) continues to be an actual task of scientific research.

[General functional state (tonus) of the brain and conditioned reflexes as the mechanisms of it's regulation].

The article is dedicated to P.S. Kupalov, due to his 120 Anniversary.

Social isolation rearing of rats decreases the nervous system's resistance to the psychogenic stress stimuli.

Established that one of the factors promoting development of the psycho-nervous diseases, are various kinds of social deprivation. The purpose of this study was investigation of importance of social interactions at the early period of postnatal in development of resistance of the nervous system against the psychogenic stress in the adult rats. At weaning, male albino outbred rats from three litters were housed socially (control rats) (n=12) or in isolation (n=14) for 8 weeks.

[Dynamics of rat behavior in conditions of psychogenic stress during alcoholic motivation].

The goal of the work was to study behavior of rats in conditions of psychogenic stress on the background of ethanol intake. Experiments were carried out on 12 mature while rats weighing 150-200g. Before the beginning of the experiments during one month rats with high and low ethanol intake have been identified.

Effects of partial intraspecies deprivation of rats on short-term image memory.

An individual's zoosocial experience plays a significant role in the formation of adaptive behavior in animals. Published data show that significant restriction of intraspecies interactions induces impairments of higher nervous activity, including such functions as learning, memory, and the control of emotions. These changes are particularly marked when deprivation of zoosocial interactions occurs in the early stage of the animal's postnatal development.

[Influence of partial intraspecies deprivation on short-term image-driven memory in rats].

Behavior and short-term memory function were studied in adult rats risen under conditions of partial intraspecies social deprivation. Testing of delayed responses (and emotional state) showed that the partial deprivation of intraspecies communication at the early stage of postnatal ontogeny led not only to disorders of short-term memory in the adult rats, but also to behavioral alterations, which may be due to impaired development of the regulatory mechanisms of motivation and emotions.

[Clinical and prognostic significance of seasonal factor in endogenous maniac states].

The study aimed at determination of clinical and prognostic significance of seasonal factor in endogenous maniac state development. Using clinico-psychopathological and clinical follow-up study, 32 patients (30 women and 2 men) aged 20-50 years with seasonal endogenous mania were examined. Seasonal mania developed in 12 patients with bipolar affective disorder, in 13 patients with schizoaffective psychosis and 7 patients with attack-like schizophrenia (F31.

[Special features of autonomic regulation in patients with seasonal depression].

Parameters of histograms distribution of ECG R-R intervals (the mode, mode amplitude, variation range) were compared in 60 healthy individuals and 45 patients with seasonal depressions. These ECG parameters reflect influence of sympathetic and parasympathetic parts of the autonomic nervous system on the rhythms of cardiac contractions. In the period of active development of depressive symptomatology the parameters of histograms in terms of R-R distribution were changed in comparison with the healthy individuals: mode was displaced to the region of the short intervals, the mode amplitude was increased and the variation range was reduced.

[Specific aspects of endogenous mental disorders with seasonal depressions].

The clinical features and the course of seasonal depressions in endogenous mental diseases were studied with psychopathological and follow-up methods. The seasonal depressions in 50 patients were developed in the psychopathological structure of manic-depressive psychosis (22 patients), schizoaffective psychosis (23) and schizoaffective variant of schizophrenia (5). There were found the considerable differences in the characteristics of seasonal depressions in the indicated endogenous psychoses.

[Psychogenic stress: theory, experiment, practice].

Experiments on animals (rodents, beasts, primates) and observation in man have ascertained that psychogenic stress is the most important defensive state of living organisms, which is constantly involved in order to maintain their interaction with external psychogenic factors. Three types of stress should be distinguished, these include normostress, hypostress, and hyperstress. Normostress has definite limits within which optimal responses, which are typical for an individual are realized.

[Characteristics of clinical effects of paxil in the treatment of endogenous depression].

47 patients with endogenous depressions were treated with paxil (paroxetine) during 4 weeks in the daily dose of 30-40 mg. Improvement of psychical state was observed in 89.3% of the patients; improvement was significant in 78.

[A structural analysis of the behavior of cynomolgus macaques under the conditions of their group housing in cages].

The conceptual basis of the present study is an idea on systemic interdependence of neurobiological phenomena (at any level of their occurrence, including the integral behavioural level). Characteristic peculiarities of probable organization of natural behavioural activity of Java monkeys (M. irus) kept in cages in monosexual groups were studied by recording ethograms with subsequent computer analysis.

[The uncoupling of the functioning of the force generation and ATP hydrolysis centers in the myocardial myofibrils in experimental informational disease].

Active and rigor force generation under the effect of electrostatic charge, the temperature and pCa, was significantly decreased in informational experimental disease. Other significant changes on the molecular level occurred in cardiomyocyte contractile apparatus in conditions of experimental informational disease.

[Etiopathogenesis of information disease].

On the basis of the results of animal experiments and observations of people the concept of the information disease was formulated. It is understood as a form of psychoneural pathology characterized by special causes bringing it about, as well as by a number of peculiarities of its manifestation and pathogenesis. Besides, the information diseases, as any nosological form, is characterized by distinct protection mechanisms.

Arterial hypertension in dogs with experimental informational pathology of their higher nervous activity.

It is shown that stable arterial hypertension can be formed in dogs by the development of experimental pathology of higher nervous activity (behavior) as a result of prolonged brain work during exposure to a combination of three unfavorable factors: a large volume of information to be processed and assimilated, shortage of time allowed for the work, and a high level of motivation of behavior. Three types of development of arterial hypertension were found, correlating with changes in behavior; self-regulating behavior reflecting defensive activity of the brain is particularly interesting. A high degree of self-regulating behavior was found to increase the resistance of the animal to arterial hypertension but weakening of self-regulation of behavior facilitates its onset and development.

[Arterial hypertension in dogs in a state of experimental informational pathology of higher nervous activity].

A stable arterial hypertension was obtained in dogs by means of experimental pathology of higher nervous activity (behavior) produced with a prolonged work of the brain in conditions of unfavourably combined triad of factors: large volume of information to be processed and assimilated, the factor of time set for such brain work, and a high level of behavioral motivation. Three types of arterial hypertension were revealed to correlate with the changes in behaviour. One form of this behaviour is the self-regulatory activity reflecting the defense mechanisms of the brain.