Conversion of caustic red mud (RM, Alumina industry waste) into building materials becoming one of the viable solution for its large scale utilization. The building materials developed using RM often results in efflorescence due to its high alkalinity, which is detrimental for the structural integrity of the buildings. The X-ray shielding tiles developed through ceramic route using the mixtures of RM, BaSO and kaolin clay also suffers from severe NaSO efflorescence when sintered above 1000 °C.
View Article and Find Full Text PDFThe Southeastern part of the Bay of Bengal is increasingly threatened by heavy metal pollution, posing significant risks to both aquatic life and human health. In this context, the contamination levels of six heavy metals-Cadmium (Cd), Lead (Pb), Zinc (Zn), Copper (Cu), Manganese (Mn), and Iron (Fe)-were assessed in the soft tissues of Green mussels (Perna viridis) from five key sites: Matamuhuri, Moheshkhali, Bakhkhali, Naf, and St. Martin.
View Article and Find Full Text PDFUlva intestinalis (UI) is widely available edible seaweed and has potential to be introduced as functional food items in Bangladesh. However, potential health hazards of this seaweed with biotoxicity assays and its relation to heavy metal contents were not evaluated previously. With these objectives, toxic effects of UI collected from floating raft culture in Monkhali Beach was evaluated using various organisms such as Chlorella vulgaris, Artemia salina, Daphnia magna, and Lactuca sativa.
View Article and Find Full Text PDFSystemic lupus erythematosus (SLE) is a complex autoimmune disease marked by chronic inflammation and tissue damage that impacts multiple organ systems and diminishes the quality of life. Among the frequent comorbidities in SLE, thyroid dysfunction, including hypothyroidism and hyperthyroidism, stands out due to its high prevalence and common autoimmune basis. This review examines the epidemiological, genetic, and immunological factors that link SLE with autoimmune thyroid diseases such as Hashimoto's thyroiditis and Graves' disease.
View Article and Find Full Text PDFAAPS PharmSciTech
December 2024
This review paper discusses the key aspects of ocular biopharmaceutics, with emphasis on the crucial role played by ocular compartmental modelling and simulation in deciphering physiological conditions related to various eye diseases. It describes eye's intricate structure and function and the need for precise and targeted drug delivery systems to address prevalent eye conditions. The review categorizes and discusses various formulations employed in ocular drug delivery, delineating their respective advantages and limitations.
View Article and Find Full Text PDFGlyphosate [N-(phosphonomethyl) glycine], a systemic herbicide, is used globally (825 million kg/year) in 750+ formulations. The International Agency for Research on Cancer classified glyphosate is a probable human carcinogen (Group 2A), but epidemiological studies have been lacking for its association with liver cancer and chronic liver disease. We analyzed urine specimens from 591 patients with newly diagnosed liver cancer, chronic liver disease (CLD), and healthy individuals from five different medical centers between 2011 to 2016 in Thailand.
View Article and Find Full Text PDFCyanotoxins are primarily produced by different species of cyanobacteria, also known as blue-green algae, and have appeared to be environmental poisons that have various toxic effects on animal health, including humans. Cyanotoxins have been linked to the development and promotion of multiple cancers in recent studies. Important cyanotoxins, such as microcystins, nodularins, and cylindrospermopsin, have been found to play significant roles in developing and promoting various cancers.
View Article and Find Full Text PDFPancreatitis is an inflammatory disease of the pancreas that can arise due to various factors, including environmental risks such as diet, alcohol, and smoking, as well as genetic predispositions. In some cases, pancreatitis may progress and become chronic, leading to irreversible damage and impaired pancreatic function. Genome-wide association studies (GWAS) have identified polymorphisms at the X-linked locus as risk factors for both sporadic and alcohol-related chronic pancreatitis.
View Article and Find Full Text PDFMagnesium is a crucial mineral that supports various enzymatic processes in the body. It plays a vital role in maintaining vascular, metabolic, and electrical homeostasis, making it an important factor for cardiovascular health. Magnesium is also involved in oxidative and inflammatory responses.
View Article and Find Full Text PDFPerfluorooctanoic acid "Forever Chemical" presents substantial ecological challenges owing to its persistence and resistance to degradation. The study introduces a novel approach by integrating ternary metal oxides-GdO, CoO, and BiO with carbon nanotubes to develop a versatile electrode material, CNT@GdCoBi NCs, which demonstrates dual functionality as both an electrochemical sensor for PFOA and a component for energy storage devices. The electrode exhibits outstanding electrochemical sensing performance, with a detection limit for PFOA of 4.
View Article and Find Full Text PDFPurpose: To report the visual outcomes and complications in eyes with retained lens fragments (RLF) following cataract surgery undergoing pars plana lensectomy (PPL) and scleral-fixated intraocular lens insertion (SFIOL).
Methods: Patients with RLF who underwent pars plana vitrectomy (PPV), PPL, and SFIOL insertion from January 2015 to December 2022 were included. The visual acuity (VA) outcomes and complication rates were compared between those receiving sutured versus sutureless SFIOL insertion as well as those undergoing SFIOL insertion at the time of PPV and PPL versus those undergoing SFIOL insertion during a subsequent surgery.
Hypertension is a prevalent health concern with significant implications for cardiovascular disease risk, affecting diverse populations worldwide and imposing substantial health system burdens. This review article explores racial and ethnic disparities in hypertension prevalence, treatment, and management, highlighting the disproportionate impact on minority populations. Certain racial and ethnic groups in the United States exhibit higher prevalence rates of hypertension and related complications due to a confluence of genetic, social, and economic factors.
View Article and Find Full Text PDFThe study examines export impact of Pakistan's integration into Shanghai Cooperation Organization (SCO) on its export's performance. We apply Poisson Pseudo-Maximum Likelihood (PPML) on augmented gravity model to estimate trade data from the period before and after permanent membership with Shanghai Cooperation Organization in 2017. The study aims to explore changes in exports volume and analyze the key mechanism through which Shanghai Cooperation Organization promotes exports.
View Article and Find Full Text PDFLower lip reconstruction following oral and neck oncosurgery presents significant challenges in maintaining function and esthetics. This case report describes a novel application of the digastric tendon for repairing the soft tissue of the lower lip in a patient undergoing wide excision of a lesion, bilateral modified radical neck dissection, segmental mandibulectomy, and free fibula flap repair. This innovative approach aims to maintain oral competence, strengthen the flap, and enhance esthetics.
View Article and Find Full Text PDFSingle-cell RNA sequencing (scRNA-seq) technology enables the precise analysis of individual cell transcripts with high sensitivity and throughput. When integrated with multiomics technologies, scRNA-seq significantly enhances the understanding of cellular diversity, particularly within the tumor microenvironment. Similarly, single-cell DNA sequencing has emerged as a powerful tool in cancer research, offering unparalleled insights into the genetic heterogeneity and evolution of tumors.
View Article and Find Full Text PDFBackground: " (ECC)" is a prevalent and serious oral health issue affecting preschool-aged children globally, with adverse effects on their overall health and well-being.
Objective: This center-based research designed to investigate the prevalence and management of ECC among preschoolers within a specific setting and evaluate associated factors.
Methods: A cross-sectional research design was employed, involving 300 preschoolers aged 3 to 5 years.
Recognizing the challenges posed by chemotherapy, specifically the hepatotoxic effects of drugs like cisplatin, this study aimed to examine the hepatoprotective potential of dapagliflozin to mitigate cisplatin-induced hepatotoxicity in a rat model. This study focused on repurposing drugs such as dapagliflozin and natural agents like silymarin as potential interventions to address cisplatin-induced hepatotoxicity. Thirty adult female Wistar rats were distributed into five groups and treated with cisplatin alone, silymarin, dapagliflozin, or a combination of dapagliflozin and silymarin accordingly for 45 days.
View Article and Find Full Text PDFMinimally invasive liver surgery, particularly hepatectomy, has evolved significantly with the advent of laparoscopic and robotic techniques. These approaches offer potential benefits over traditional open surgery, including reduced postoperative pain, shorter hospital stays, faster recovery, and improved cosmetic outcomes. This comprehensive review aims to compare the operative efficiency and postoperative recovery outcomes of robotic and laparoscopic hepatectomy.
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