Functional Brain Network Identification in Opioid Use Disorder Using Machine Learning Analysis of Resting-State fMRI BOLD Signals.

Understanding the neurobiology of opioid use disorder (OUD) using resting-state functional magnetic resonance imaging (rs-fMRI) may help inform treatment strategies to improve patient outcomes. Recent literature suggests temporal characteristics of rs-fMRI blood oxygenation level-dependent (BOLD) signals may offer complementary information to functional connectivity analysis. However, existing studies of OUD analyze BOLD signals using measures computed across all time points.

Texture Estimation for Abnormal Tissue Segmentation in Brain MRI.

This chapter discusses multifractal texture estimation and characterization of brain lesions (necrosis, edema, enhanced tumor, nonenhanced tumor, etc.) in magnetic resonance (MR) images. This work formulates the complex texture of tumor in MR images using a stochastic model known as multifractional Brownian motion (mBm).

Special Section Editorial: Artificial Intelligence for Medical Imaging in Clinical Practice.

The editorial introduces the JMI Special Section on Artificial Intelligence for Medical Imaging in Clinical Practice.

Prediction of Rapid Early Progression and Survival Risk with Pre-Radiation MRI in WHO Grade 4 Glioma Patients.

Recent clinical research describes a subset of glioblastoma patients that exhibit REP prior to the start of radiation therapy. Current literature has thus far described this population using clinicopathologic features. To our knowledge, this study is the first to investigate the potential of conventional radiomics, sophisticated multi-resolution fractal texture features, and different molecular features (MGMT, IDH mutations) as a diagnostic and prognostic tool for prediction of REP from non-REP cases using computational and statistical modeling methods.

QU-BraTS: MICCAI BraTS 2020 Challenge on Quantifying Uncertainty in Brain Tumor Segmentation - Analysis of Ranking Scores and Benchmarking Results.

Deep learning (DL) models have provided state-of-the-art performance in various medical imaging benchmarking challenges, including the Brain Tumor Segmentation (BraTS) challenges. However, the task of focal pathology multi-compartment segmentation (e.g.

Monocular Camera Viewpoint-Invariant Vehicular Traffic Segmentation and Classification Utilizing Small Datasets.

The work presented here develops a computer vision framework that is view angle independent for vehicle segmentation and classification from roadway traffic systems installed by the Virginia Department of Transportation (VDOT). An automated technique for extracting a region of interest is discussed to speed up the processing. The VDOT traffic videos are analyzed for vehicle segmentation using an improved robust low-rank matrix decomposition technique.

Artificial Intelligence and Machine Learning in Optical Information Processing: introduction to the feature issue.

This special feature issue covers the intersection of topical areas in artificial intelligence (AI)/machine learning (ML) and optics. The papers broadly span the current state-of-the-art advances in areas including image recognition, signal and image processing, machine inspection/vision and automotive as well as areas of traditional optical sensing, interferometry and imaging.

Deep Learning Based Superconducting Radio-Frequency Cavity Fault Classification at Jefferson Laboratory.

This work investigates the efficacy of deep learning (DL) for classifying C100 superconducting radio-frequency (SRF) cavity faults in the Continuous Electron Beam Accelerator Facility (CEBAF) at Jefferson Lab. CEBAF is a large, high-power continuous wave recirculating linac that utilizes 418 SRF cavities to accelerate electrons up to 12 GeV. Recent upgrades to CEBAF include installation of 11 new cryomodules (88 cavities) equipped with a low-level RF system that records RF time-series data from each cavity at the onset of an RF failure.

Joint Modeling of RNAseq and Radiomics Data for Glioma Molecular Characterization and Prediction.

RNA sequencing (RNAseq) is a recent technology that profiles gene expression by measuring the relative frequency of the RNAseq reads. RNAseq read counts data is increasingly used in oncologic care and while radiology features (radiomics) have also been gaining utility in radiology practice such as disease diagnosis, monitoring, and treatment planning. However, contemporary literature lacks appropriate (henceforth, ) joint modeling where RNAseq distribution is adaptive and also preserves the nature of RNAseq read counts data for glioma grading and prediction.

Deep Neural Network Analysis of Pathology Images With Integrated Molecular Data for Enhanced Glioma Classification and Grading.

Gliomas are primary brain tumors that originate from glial cells. Classification and grading of these tumors is critical to prognosis and treatment planning. The current criteria for glioma classification in central nervous system (CNS) was introduced by World Health Organization (WHO) in 2016.

Dynamic Perturbation of Weights for Improved Data Reconstruction in Unsupervised Learning.

The concept of weight pruning has shown success in neural network model compression with marginal loss in classification performance. However, similar concepts have not been well recognized in improving unsupervised learning. To the best of our knowledge, this paper proposes one of the first studies on weight pruning in unsupervised autoencoder models using non-imaging data points.

Deep Cellular Recurrent Network for Efficient Analysis of Time-Series Data With Spatial Information.

Efficient processing of large-scale time-series data is an intricate problem in machine learning. Conventional sensor signal processing pipelines with hand-engineered feature extraction often involve huge computational costs with high dimensional data. Deep recurrent neural networks have shown promise in automated feature learning for improved time-series processing.

Context aware deep learning for brain tumor segmentation, subtype classification, and survival prediction using radiology images.

A brain tumor is an uncontrolled growth of cancerous cells in the brain. Accurate segmentation and classification of tumors are critical for subsequent prognosis and treatment planning. This work proposes context aware deep learning for brain tumor segmentation, subtype classification, and overall survival prediction using structural multimodal magnetic resonance images (mMRI).

Longitudinal brain tumor segmentation prediction in MRI using feature and label fusion.

This work proposes a novel framework for brain tumor segmentation prediction in longitudinal multi-modal MRI scans, comprising two methods; feature fusion and joint label fusion (JLF). The first method fuses stochastic multi-resolution texture features with tumor cell density feature to obtain tumor segmentation predictions in follow-up timepoints using data from baseline pre-operative timepoint. The cell density feature is obtained by solving the 3D reaction-diffusion equation for biophysical tumor growth modelling using the Lattice-Boltzmann method.

A Multi-Organ Nucleus Segmentation Challenge.

Generalized nucleus segmentation techniques can contribute greatly to reducing the time to develop and validate visual biomarkers for new digital pathology datasets. We summarize the results of MoNuSeg 2018 Challenge whose objective was to develop generalizable nuclei segmentation techniques in digital pathology. The challenge was an official satellite event of the MICCAI 2018 conference in which 32 teams with more than 80 participants from geographically diverse institutes participated.

Feature-Guided Deep Radiomics for Glioblastoma Patient Survival Prediction.

Glioblastoma is recognized as World Health Organization (WHO) grade IV glioma with an aggressive growth pattern. The current clinical practice in diagnosis and prognosis of Glioblastoma using MRI involves multiple steps including manual tumor sizing. Accurate identification and segmentation of multiple abnormal tissues within tumor volume in MRI is essential for precise survival prediction.

Glioma grading using structural magnetic resonance imaging and molecular data.

A glioma grading method using conventional structural magnetic resonance image (MRI) and molecular data from patients is proposed. The noninvasive grading of glioma tumors is obtained using multiple radiomic texture features including dynamic texture analysis, multifractal detrended fluctuation analysis, and multiresolution fractal Brownian motion in structural MRI. The proposed method is evaluated using two multicenter MRI datasets: (1) the brain tumor segmentation (BRATS-2017) challenge for high-grade versus low-grade (LG) and (2) the cancer imaging archive (TCIA) repository for glioblastoma (GBM) versus LG glioma grading.

Glioblastoma and Survival Prediction.

Glioblastoma is a stage IV highly invasive astrocytoma tumor. Its heterogeneous appearance in MRI poses critical challenge in diagnosis, prognosis and survival prediction. This work extracts a total of 1207 different types of texture and other features, tests their significance and prognostic values, and then utilizes the most significant features with Random Forest regression model to perform survival prediction.

Sparse Simultaneous Recurrent Deep Learning for Robust Facial Expression Recognition.

Facial expression recognition is a challenging task that involves detection and interpretation of complex and subtle changes in facial muscles. Recent advances in feed-forward deep neural networks (DNNs) have offered improved object recognition performance. Sparse feature learning in feed-forward DNN models offers further improvement in performance when compared to the earlier handcrafted techniques.

A Feasibility Study of Autism Behavioral Markers in Spontaneous Facial, Visual, and Hand Movement Response Data.

Autism spectrum disorder (ASD) is a neurodevelopmental disability with atypical traits in behavioral and physiological responses. These atypical traits in individuals with ASD may be too subtle and subjective to measure visually using tedious methods of scoring. Alternatively, the use of intrusive sensors in the measurement of psychophysical responses in individuals with ASD may likely cause inhibition and bias.

Quantitative MR Image Analysis for Brian Tumor.

This paper presents an integrated quantitative MR image analysis framework to include all necessary steps such as MRI inhomogeneity correction, feature extraction, multiclass feature selection and multimodality abnormal brain tissue segmentation respectively. We first obtain mathematical algorithm to compute a novel Generalized multifractional Brownian motion (GmBm) texture feature. We then demonstrate efficacy of multiple multiresolution texture features including regular fractal dimension (FD) texture, and stochastic texture such as multifractional Brownian motion (mBm) and GmBm features for robust tumor and other abnormal tissue segmentation in brain MRI.

Improved brain tumor segmentation by utilizing tumor growth model in longitudinal brain MRI.

In this work, we propose a novel method to improve texture based tumor segmentation by fusing cell density patterns that are generated from tumor growth modeling. In order to model tumor growth, we solve the reaction-diffusion equation by using Lattice-Boltzmann method (LBM). Computational tumor growth modeling obtains the cell density distribution that potentially indicates the predicted tissue locations in the brain over time.

Real-Time Epileptic Seizure Detection Using EEG.

This paper proposes a novel patient-specific real-time automatic epileptic seizure onset detection, using both scalp and intracranial electroencephalogram (EEG). The proposed technique obtains harmonic multiresolution and self-similarity-based fractal features from EEG for robust seizure onset detection. A fast wavelet decomposition method, known as harmonic wavelet packet transform (HWPT), is computed based on Fourier transform to achieve higher frequency resolutions without recursive calculations.

Glioma Grading Using Cell Nuclei Morphologic Features in Digital Pathology Images.

This work proposes a computationally efficient cell nuclei morphologic feature analysis technique to characterize the brain gliomas in tissue slide images. In this work, our contributions are two-fold: 1) obtain an optimized cell nuclei segmentation method based on the pros and cons of the existing techniques in literature, 2) extract representative features by k-mean clustering of nuclei morphologic features to include area, perimeter, eccentricity, and major axis length. This clustering based representative feature extraction avoids shortcomings of extensive tile [1] [2] and nuclear score [3] based methods for brain glioma grading in pathology images.

ISLES 2015 - A public evaluation benchmark for ischemic stroke lesion segmentation from multispectral MRI.

Ischemic stroke is the most common cerebrovascular disease, and its diagnosis, treatment, and study relies on non-invasive imaging. Algorithms for stroke lesion segmentation from magnetic resonance imaging (MRI) volumes are intensely researched, but the reported results are largely incomparable due to different datasets and evaluation schemes. We approached this urgent problem of comparability with the Ischemic Stroke Lesion Segmentation (ISLES) challenge organized in conjunction with the MICCAI 2015 conference.