Integrative analysis of transcriptome and metabolome reveal molecular mechanism of tolerance to salt stress in rice.

Background: Salt stress is considered to be one of the major abiotic stresses influencing rice growth and productivity. To improve rice crop productivity in saline soils, it is essential to choose a suitable variety for mitigating salt stress and gain a deep understanding of the underlying mechanisms. The current study explored the salt tolerance mechanism of wild rice 'HD96-1 (salt resistive)' and conventional rice 'IR29 (salt sensitive)' by evaluating morph-physiological, transcriptomic, and metabolomic approaches.

Leading report on the molecular prevalence of emerging pathogens Hepatozoon sp. and Lankesterella sp. in the blood samples of seven wild lizard species.

Despite of having rich reptilian fauna, the wild lizards from Pakistan remained unexplored for the presence of blood borne parasites. The present study was designed to report the molecular epidemiology and phylogenetic evaluation of various blood borne pathogens (Hepatozoon sp., Schellackia spp.

An easy to apply tube gel for lidocaine induced pain relief and 2-deoxy-d-ribose accelerated wound healing.

Many wounds can be challenging to manage because of pain and poor angiogenesis. An ideal treatment for such wounds would be a gel that can induce angiogenesis to accelerate wound healing and to reduce pain. Our aim in this study was to explore combining 2-deoxy-d-ribose (2dDR) to induce angiogenesis with lidocaine hydrochloride to reduce pain in the form of a tube-based gel.

Decontamination of Sewage Wastewater by an Aeration Method Utilizing Water Hardness-Reducing Spirulina platensis.

This study investigates the potential of Spirulina platensis, a blue-green algae species, for the remediation of sewage wastewater, providing a sustainable approach to wastewater management. Over a 20-day period, with aeration at 3 L/min, Spirulina effectively reduced key pollutants, including chemical oxygen demand (COD), phosphate, nitrate, magnesium, and other impurities. Advanced analyses using FTIR, SEM, and EDX revealed that the primary mechanism of remediation was the adsorption of contaminants onto Spirulina.

Imaging and Surveillance of Chronic Aortic Dissection: Current Practice and Future Directions.

Chronic aortic dissection is a complex disease with a heterogenous clinical course. Specialised imaging is necessary for the long-term surveillance of this disease to identify patients who meet the criteria for intervention, and to monitor surgically treated patients for complications. Whilst computed tomography and magnetic resonance imaging are the most widely utilised modalities, providing a high degree of anatomical detail and reproducible aortic measurements, they are not without significant limitations.

Assessment of cellular immune phenotype of peripheral blood mononuclear cells in Bangladeshi children with severe acute malnutrition.

Children suffering from severe acute malnutrition (SAM) have a weakened immune system. The relationship between malnutrition and alterations in the frequency of peripheral blood mononuclear cells (PBMCs) remains unclear. This study investigated the altered immune responses in Bangladeshi children with SAM compared to healthy children.

Improved Limit on Neutrinoless Double Beta Decay of ^{100}Mo from AMoRE-I.

AMoRE searches for the neutrinoless double beta decay using 100 kg of enriched ^{100}Mo. Scintillating molybdate crystals coupled with a metallic magnetic calorimeter operate at milli-Kelvin temperatures to measure the energy of electrons emitted in the decay. AMoRE-I is a demonstrator for the full-scale AMoRE, operated at the Yangyang Underground Laboratory for over two years.

Impact of VRE-active perioperative prophylaxis in liver transplant patients colonized by Vancomycin-Resistant Enterococci.

Background: Data regarding the effectiveness of vancomycin resistant Enterococci (VRE) active prophylaxis for preventing early post-liver transplant (LT) VRE infections in VRE-colonized patients are scarce.

Methods: One-hundred-thirty-one pre-LT VRE colonized patients who underwent liver transplantation were enrolled in a retrospective, observational, multicenter study. The incidence of early-onset VRE infections was compared between patients who received active prophylaxis for VRE and those who did not.

Evolution of long COVID over two years in hospitalised and non-hospitalised survivors in Bangladesh: a longitudinal cohort study.

Background: In developing settings, comparative data on COVID hospitalised survivors (HS) and non-hospitalised survivors (NHS) is scarce. We determined burdens, incidence, evolution, and associated factors of long COVID-19 over two years among these groups.

Methods: We conducted a longitudinal cohort study in Dhaka, Bangladesh, and recruited confirmed COVID-19 survivors from December 2020 to May 2021 (previously reported).

Insect metamorphosis and chitin metabolism under miRNA regulation: a review with current advances.

Insect metamorphosis is a complex developmental process regulated by microRNAs (miRNAs) and hormonal signaling pathways. Key genes driving insect ontogenic changes are precisely modulated by miRNAs, which interact with 20-hydroxyecdysone (20E) and juvenile hormone (JH) to coordinate developmental transitions. Over the past decade, significant progress has been made in understanding miRNA biogenesis, their regulatory roles in gene expression, and their involvement in critical biological processes, including metamorphosis and chitin metabolism.

Platelet rich plasma versus corticosteroids for lateral epicondylitis: a meta-analysis of randomized clinical trials.

Background: Lateral epicondylitis, colloquially known as tennis elbow, is a common cause of elbow pain and daily task disability. Caused by repetitive movement, it is typically a degenerative rather than inflammatory event and affects mostly middle-aged patients. Despite its good prognostic nature, its economic burden on the healthcare system encourages research on the efficacity of non-operative injection treatments.

Persistence and Recurrence of Primary Hyperparathyroidism.

Persistent and recurrent primary hyperparathyroidism (PHPT) represent significant challenges in the management of PHPT. Persistent PHPT is defined as persistence of hypercalcemia following parathyroidectomy (PTX) or the recurrence of hypercalcemia within the first 6 months following surgery. Recurrent PHPT is defined as recurrence of hypercalcemia after 6 months following PTX and requires normalization of serum calcium prior to the recurrence.

Multi-epitope-based vaccine models prioritization against Astrovirus MLB1 using immunoinformatics and reverse vaccinology approaches.

Astrovirus MLB1 (HAstV-MLB1) is non-enveloped RNA virus that cause acute gastroenteritis infection. Despite research progress about infection and pathogenesis of HAstV-MLB1, Currently, no vaccine has been developed to effectively combat this pathogen. The current study is based on immunoinformatics and reverse vaccinology approaches to design next-generation, multi-epitope-based vaccine models against HAstV-MLB1.

Perovskite Type ABO Oxides in Photocatalysis, Electrocatalysis, and Solid Oxide Fuel Cells: State of the Art and Future Prospects.

Since photocatalytic and electrocatalytic technologies are crucial for tackling the energy and environmental challenges, significant efforts have been put into exploring advanced catalysts. Among them, perovskite type ABO oxides show great promising catalytic activities because of their flexible physical and chemical properties. In this review, the fundamentals and recent progress in the synthesis of perovskite type ABO oxides are considered.

Metabolic landscape in bladder cancer.

Purpose Of Review: This review examines the existing literature on metabolic pathways associated with bladder cancer (BC) and investigates four domains: (1) diagnoses, (2) cancer classification (staging & grading), (3) tracking, and (4) treatment.

Recent Findings: A systematic search of relevant databases identified studies meeting predefined inclusion criteria. A diverse array of metabolic pathways was found to hold significant biological and clinical relevance to BC, with particular emphasis on amino acid (AA), lipid, nucleic acid (NA), and bioenergetic pathways.

Synthetic gene circuits in plants: recent advances and challenges.

Plant synthetic biology is a rapidly advancing multidisciplinary research area that applies engineering principles to design, construct, and implement new plant capabilities at the molecular, cellular, and whole organism scales. Synthetic gene circuits are important tools for enabling increased customizability in the control of gene expression in plants, with widespread applications spanning new approaches for basic biology to introduction of new traits for advancing agriculture. In this review, we first aimed to provide a comprehensive understanding of synthetic circuits.

Unveiling cutting-edge developments in defective BiOI nanomaterials: Precise manipulation and improved functionalities towards bolstered photocatalysis.

Defect engineering represents a paradigm shift in tailoring nanomaterials for enhanced catalytic performance across various applications. This manuscript succinctly highlights the significance of defect engineering in improving the catalytic performance of BiOI nanoparticles for multiple applications, particularly in photocatalysis. The photocatalytic process of BiOI semiconductor is intricately linked to its indirect bandgap and layered crystalline structure.

Awareness of the Role of Artificial Intelligence in Health Care among Undergraduate Nursing Students: A Descriptive Cross-Ssectional Study.

Background: Artificial intelligence (AI) has the potential to revolutionize healthcare by improving efficiency and reducing errors; however, challenges such as inadequate funding and lack of awareness among healthcare professionals hinder its integration into healthcare service delivery.

Aim: To assess the awareness of undergraduate student nurses regarding the role of AI in healthcare.

Design: A descriptive cross-sectional design was used.

Physicians' Perspectives Regarding Informal Health Practitioners in Bangladesh.

Rural Bangladesh faces challenges of limited health care resources and a shortage of health care professionals. Informal providers, particularly village doctors, fill this void by being a first point of care and a bridge to the formal health care system. This study explores formally trained physicians' perspectives on village doctors' role in the health care system.

Family History in the Context of CKD.

Background: A family history of health conditions may reflect shared genetic and/or environmental risk. It is not well known to what extent family history impacts outcomes among patients with chronic kidney disease (CKD). Herein, we studied the associations of family history of CKD, diabetes, and other conditions with common comorbidities and kidney disease progression among patients with CKD.

Target isolation and anti-proliferative potency of furocoumarin derivative from fruit pulp.

is a member of the Rutaceae family and a source of diverse biological properties. Most studies have focused on the extract from the dried fruit pulp, but the fresh pulp remains unexplored. This study reports the crystal isolation of imperatorin from fresh fruit pulp using ethyl acetate extract which was confirmed by spectroscopic techniques.

LILRB3 genetic variation is associated with kidney transplant failure in African American recipients.

African American (AA) kidney transplant recipients exhibit a higher rate of graft loss compared with other racial and ethnic populations, highlighting the need to identify causative factors. Here, in the Genomics of Chronic Allograft Rejection cohort, pretransplant blood RNA sequencing revealed a cluster of four consecutive missense single-nucelotide polymorphisms (SNPs), within the leukocyte immunoglobulin-like receptor B3 (LILRB3) gene, strongly associated with death-censored graft loss. This SNP cluster (named LILRB3-4SNPs) encodes missense mutations at amino acids 617-618 proximal to a SHP1/2 phosphatase-binding immunoreceptor tyrosine-based inhibitory motif.

The mediating role of cognitive arousal in the relationship between impulsivity and sleep quality among college students: a random intercept cross-lagged panel analysis.

Impulsivity, cognitive arousal, and sleep quality are critical factors affecting college students' well-being and academic performance. While impulsivity negatively influences sleep quality, the mediating role of cognitive arousal remains underexplored. The present study assesses how impulsivity affects sleep quality through cognitive arousal.

Safety and Efficacy Evaluation of Composite Collagen in Human Infraorbital Anti-aging and Nude Mouse Skin Photoaging.

Background: Collagen is currently a widely used injectable filler material. Due to the complexity and specificity of the infraorbital structure and function, it undergoes various aging changes earlier in the facial aging process. Additionally, continuous exposure to Ultraviolet (UV) leads to photoaging of the skin.