[Oxidative phosphorylation uncoupling in hyperthyroidism as a result of activating cyclosporin-sensitive pores in the inner mitochondrial membrane by water soluble modulators from rat liver cytoplasm].

Small concentrations of low molecular weight modulators of the functional state of rat liver cytoplasm mitochondria, which uncouple oxidative phosphorylation, induce phosphate-dependent transport of potassium and hydrogen ions. In contrast, high concentrations of these compounds induce nonspecific transport of monovalent cations and sucrose (K+ > H+ > Na+ > or = Li+ > sucrose). The effect of cytoplasmic modulators on oxidative phosphorylation and permeability of the inner mitochondrial membrane in inhibited by cyclosporin A and controlled by physiological concentrations of Ca2+.

[Effective diameter of pores in rat liver mitochondria inner membrane and selectivity of transport of monovalent cations with a submicromolar concentration of Ca2+ ions or A23187 and EDTA].

Studies of swelling of rat liver mitochondria in isoosmotic solutions of nonelectrolytes in the presence of respiration inhibitors revealed that submicromolar concentrations of Ca2+ increase the diameter of pores in the inner mitochondrial membrane--from 5.5-6.0 A (10(-8) M Ca2+) up to 7.

[A physiological method of annuloplasty of the mitral valve].

The work deals with an anatomo-functional substantiation of plastic repair of the mitral valve. Isolated annuloplasty was carried out in 20 patients with mitral incompetence, annuloplasty with aortic prosthetics was conducted in 13 patients. The method allows a prosthesis with a larger diameter to be used in the last named group of patients.

[Regulation of thyroid hormones of the interaction of mitochondria with low-molecular weight cytoplasmic mediators, induced by phosphate- dependent transport of K+ and H+ ions through the mitochondrial inner membrane].

In vivo thyroid hormones control the binding to mitochondria of low molecular weight water-soluble cytoplasmic mediators that are capable to induce oxidative phosphorylation uncoupling, by increasing the sensitivity of mitochondria to the effects of these mediators. In hyperthyroid rat liver mitochondria cytoplasmic mediators stimulate the phosphate-dependent transport of K+ and H+ in a greater degree than in liver mitochondria of control rats. The increase in the oxidative phosphorylation uncoupling by cytoplasmic mediators is one of mechanisms of thermogenesis stimulation by thyroid hormones.