Publications by authors named "Khalilatul-Hanisah Mohd-Kahliab"
Accumulation of damaged biomolecules in body tissues is the primary cause of aging and age-related chronic diseases. Since this damage often occurs spontaneously, it has traditionally been regarded as untreatable, with typical therapeutic strategies targeting genes or enzymes being ineffective in this domain. In this report, we demonstrate that an antibody targeting the isoDGR damage motif in lung tissue can guide immune clearance of harmful damaged proteins in vivo, effectively reducing age-linked lung inflammation.
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- Aging leads to molecular damage that disrupts normal body functions, particularly affecting the NGR amino acid sequence, which transforms into the harmful isoDGR, promoting chronic inflammation and cardiovascular issues.
- Anti-isoDGR immunotherapy has been shown to extend the lifespan of Pcmt1 mice by reducing isoDGR levels in tissues and lowering inflammation, thereby improving cognitive and motor functions.
- This study suggests that targeting damaged proteins associated with aging through immunotherapy could be a promising approach for treating various degenerative diseases in humans.