Publications by authors named "Khalid Sultan A M Sheikhan"
Article Synopsis
- - Cutaneous T-cell lymphomas (CTCL) are a complex form of skin cancer with limited treatments, and they often resist therapy, making understanding cancer metabolism crucial for developing new treatments.
- - The study investigates how Glabridin, a compound found in licorice, affects CTCL by triggering programmed cell death (PCD) and inhibiting cancer cell growth through pathways like MAPK and ERK signaling.
- - Glabridin not only promotes PCD in CTCL cells but also enhances their sensitivity to the anti-cancer drug bortezomib, indicating its potential as a powerful anti-cancer agent by targeting multiple metabolic pathways involved in cancer proliferation.
Cancer 'stemness' is fundamental to cancer existence. It defines the ability of cancer cells to indefinitely perpetuate as well as differentiate. Cancer stem cell populations within a growing tumor also help evade the inhibitory effects of chemo- as well as radiation-therapies, in addition to playing an important role in cancer metastases.
View Article and Find Full Text PDFSkin, the largest vital organ of the human body, provides the first line of defense against biological, non-biological and xenobiotics exposure. Over the years, due to increased anthropogenic activities including industrialization and pollution, a steep increase in cutaneous pathological conditions such as malignancies, dermatitis, and psoriasis has been detected. Indeed, due to the complex nature of cutaneous inflammatory diseases, further investigations are required to produce a better outcome in patient care.
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