Efficacy of tranexamic acid in reducing blood loss in total knee replacements.

Objective: To assess the efficacy of tranexamic acid in reducing blood loss in total knee replacement.

Methods: The retrospective study was conducted at Quaid-e-Azam International Hospital, Islamabad, Pakistan, and comprised data of patients who underwent total knee replacement between January 2012 and December 2014. The effect of tranexamic acid on postoperative haemoglobin, hematocrit and number of blood units transfused was noted and compared between cases who had received standard dose of tranexamic acid with those who had not received it.