Multi-Agent DRL for Air-to-Ground Communication Planning in UAV-Enabled IoT Networks.

In this paper, we present a novel method to enhance the sum-rate effectiveness in full-duplex unmanned aerial vehicle (UAV)-assisted communication networks. Existing approaches often couple uplink and downlink associations, resulting in suboptimal performance, particularly in dynamic environments where user demands and network conditions are unpredictable. To overcome these limitations, we propose a decoupling of uplink and downlink associations for ground-based users (GBUs), significantly improving network efficiency.

The potential role of multifunctional human amniotic epithelial cells in pancreatic islet transplantation.

Pancreatic islet cell transplantation has proven efficacy as a treatment for type 1 diabetes mellitus, chiefly in individuals who are refractory to conventional insulin replacement therapy. At present its clinical use is restricted, firstly by the limited access to suitable donor organs but also due to factors associated with the current clinical transplant procedure which inadvertently impair the long-term functionality of the islet graft. Of note, the physical, biochemical, inflammatory, and immunological stresses to which islets are subjected, either during pretransplant processing or following implantation are detrimental to their sustained viability, necessitating repeated islet infusions to attain adequate glucose control.

Low gravity rotational culture and the integration of immunomodulatory stem cells reduce human islet allo-reactivity.

Modification of human islets prior to transplantation may improve long-term clinical outcome in terms of diabetes management, by supporting graft function and reducing the potential for allo-rejection. Intragraft incorporation of stem cells secreting beta (β)-cell trophic and immunomodulatory factors represents a credible approach, but requires suitable culture methods to facilitate islet alteration without compromising integrity. This study employed a three-dimensional rotational cell culture system (RCCS) to achieve modification, preserve function, and ultimately influence immune cell responsiveness to human islets.

An infected urachal cyst presenting as an acute abdomen - A case report.

Introduction: An infected urachal cyst is one of a spectrum of presentations of urachal pathology, all of which are rare in adulthood.

Presentation Of Case: We report the case of a 45-year-old obese Russian lady who presented with a 2-week history of suprapubic pain radiating to the right iliac fossa. Although previously fit and well, she had a history of 17 miscarriages.

Reverse flow posterior interosseous flap: experience with 53 flaps at Nishtar Hospital, Multan.

Objective: To assess the efficacy of reverse flow posterior interosseous artery flap for the coverage of large variety of hand/wrist defects.

Methods: The prospective study was conducted a the Department of Plastic Surgery and the Burns Unit of Nishtar Hospital, Multan, Pakistan, from June 2008 to June 2010. The study comprised 53 reverse flow posterior interosseous artery flaps in 50 patients for the coverage of hand/wrist defects both in emergency and elective settings.

Human amniotic epithelial cells induce localized cell-mediated immune privilege in vitro: implications for pancreatic islet transplantation.

Chronic systemic immunosuppression in cell replacement therapy restricts its clinical application. This study sought to explore the potential of cell-based immune modulation as an alternative to immunosuppressive drug therapy in the context of pancreatic islet transplantation. Human amniotic epithelial cells (AEC) possess innate anti-inflammatory and immunosuppressive properties that were utilized to create localized immune privilege in an in vitro islet cell culture system.

Monitoring the function and use of a clinical decision support system.

The continuous monitoring of systems that provide healthcare functions is essential to ensuring their constant operation, optimal performance, and value to providers. Log files are rich resources for studying the various aspects of systems including their function and use. Here, we describe the types of log files, applications of results from their analysis, and creation of a monitoring tool for the Vigilens Health Monitor (an operational clinical decision support system at New York-Presbyterian Hospital).

Bilateral synchronous ductal carcinoma in situ in a young man: case report and review of the literature.

We report a rare case of synchronous bilateral ductal carcinoma in situ (DCIS) developing in a man with long-standing gynecomastia. He underwent bilateral staged subcutaneous mastectomies with the right side being performed first at age 26 years. Histology confirmed bilateral pure DCIS.

Automated real-time detection and notification of positive infection cases.

Infection control in the healthcare setting is an essential component for patient safety and quality of care. To assist with daily infection control functions, we have implemented an alert in the Vigilens Health Monitor (a clinical decision support system at our institution) for real-time detection and notification of positive infection cases in both inpatient and outpatient settings.