Publications by authors named "Khalid Chebbac"
Marine algae are renowned for their health benefits due to the presence of functional bioactive compounds. In this context, this study aims to valorize the extract of a seaweed, (), through phytochemical characterization using liquid chromatography-mass spectrometry (HPLC-MS), as well as in vitro and in silico evaluation of its biological activities (antioxidant and antimicrobial). Phytochemical characterization revealed that the ethanolic extract of (DdEx) is rich in phenolic compounds, with a total of 22 phycocompounds identified.
View Article and Find Full Text PDFThis work describes the synthesis, characterization, and in vitro and in silico evaluation of the biological activity of new functionalized isoxazole derivatives. The structures of all new compounds were analyzed by IR and NMR spectroscopy. The structures of and were further confirmed by single crystal X-ray and their compositions unambiguously determined by mass spectrometry (MS).
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- A series of new isoxazole derivatives with sulfonate ester functionality were synthesized from aurone using an efficient methodology, yielding good results reproducibly.
- The structures of these compounds were confirmed through NMR and mass spectrometry, along with theoretical studies to assess their geometrical and electronic properties.
- The synthesized compounds showed moderate antibacterial activity against certain bacteria and effective antioxidant properties, while molecular docking and dynamics studies indicated promising interactions with bacterial proteins and favorable pharmacokinetic profiles.
Article Synopsis
- - This study focuses on the essential oil extracted from an aromatic plant (AA), known for its medicinal properties, and analyzes its phytochemical composition and therapeutic benefits.
- - The essential oil demonstrates impressive antioxidant capacities, including a low IC value for DPPH free radical scavenging and high total antioxidant capacity, indicating its effectiveness in neutralizing free radicals.
- - Additionally, the essential oil shows notable antibacterial and antifungal activities, particularly against certain strains, suggesting its potential as an alternative treatment for combating drug-resistant microbes.
Article Synopsis
- - The study focused on examining the antioxidant and antimicrobial activities of essential oils (EOF) extracted through hydro-distillation and analyzed using gas chromatography and mass spectrometry (GC/MS).
- - Three antioxidant tests (DPPH, TAC, FRAP) showed EOF had strong antioxidant properties, with an impressive DPPH IC50 of 16.00 µg/mL and significant total antioxidant content (1094.19 mg AAE/g EO).
- - The EOF demonstrated potent antimicrobial effects with minimal inhibitory concentrations (MIC) as low as 1.34 μg/mL against certain bacteria and strong antifungal activity against specific fungal strains, highlighting its potential in addressing infections.
A series of new heterocycle hybrids incorporating pyrazole and isoxazoline rings was successfully synthesized, characterized, and evaluated for their antimicrobial responses. The synthesized compounds were obtained utilizing -alkylation and 1,3-dipolar cycloaddition reactions, as well as their structures were established through spectroscopic methods and confirmed by mass spectrometry. To get more light on the regioselective synthesis of new hybrid compounds, mechanistic studies were performed using DFT calculations with B3LYP/6-31G(d,p) basis set.
View Article and Find Full Text PDFGC-MS Profiling, Antioxidant, Antimicrobial, and NADPH Oxidase Inhibition Studies of Essential Oil of Bark.
Evid Based Complement Alternat Med
September 2022
Article Synopsis
- The study focuses on the essential oils extracted from a native mountain species in the western Mediterranean, analyzing their chemical properties and potential health benefits.
- Chemical analysis through gas chromatography revealed key compounds in the essential oils and demonstrated significant antioxidant effects through various assays.
- The essential oils showed strong antibacterial and antifungal activity, indicating their potential as natural treatments for infections, particularly highlighted by their effectiveness against specific bacterial and fungal strains.
Article Synopsis
- This study explored the essential oil extracted from Lam. (EOA), focusing on its chemical properties and potential health benefits, particularly its antioxidant and antimicrobial activities.
- The extraction process used hydrodistillation, and the oil's composition was analyzed using gas chromatography techniques, revealing 34 different compounds, with Camphor being the most prevalent at 24.97%.
- EOA demonstrated strong antioxidant effects (as shown by DPPH and FRAP assays) and exhibited significant antibacterial and antifungal activities against various pathogenic bacteria and fungi, suggesting its potential as a natural alternative for fighting infections and managing oxidative stress.
Article Synopsis
- * Key components of the EOW included high levels of carvacrol (31.87%) and thymol (30.08%), and the oil showed significant mortality rates against insects at various concentrations, especially at 20 μL/L.
- * EOW also demonstrated strong antifungal activity, effectively inhibiting mycelial growth of tested fungi, suggesting it could be a natural alternative to synthetic insecticides and fungicides.
Background: L. () is a medicinal and aromatic plant belonging to the family Asteraceae that is more widespread in the folded Middle Atlas Mountains, Morocco.
Materials And Methods: This study was run to investigate the phytochemical composition and antioxidant, antibacterial, and antifungal activities of L.