Chemically Defined Cell-Free Metabolites Demonstrate Cytoprotection in HepG2 Cells through Nrf2-Dependent Mechanism.

Centering around the concept that metabolites from the gut commensals can exert metabolic health benefits along the gut-liver axis, we tested whether the cell-free global metabolome of probiotic bacteria can exert hepatoprotective benefits against HO-induced oxidative stress. Cell-free global metabolites of (LPM) were isolated and untargeted metabolomics was performed. The free radical scavenging potentials of LPM were measured.