Effect of ginseng extract on the TGF-β1 signaling pathway in CCl-induced liver fibrosis in rats.

Background: Liver diseases are major global health problems. Ginseng extract has antioxidant, immune-modulatory and anti-inflammatory activities. This study investigated the effect of ginseng extract on carbon tetrachloride (CCl4)-induced liver fibrosis in rats.

Protection against tacrolimus-induced cardiotoxicity in rats by olmesartan and aliskiren.

Context: Tacrolimus (TAC), a calcineurin inhibitor, is commonly used as an immunosuppressive agent in organ transplantation, but its clinical use may be limited due to cardiotoxicity. Olmesartan (OLM; angiotensin receptor blocker) and aliskiren (ALK; renin inhibitor) may attenuate cardiotoxicity induced by TAC by inhibition of renin-angiotensin aldosterone system.

Objective: The aim of this study was to evaluate the effect of OLM and ALK on TAC-induced cardiotoxicity.

Treatment with aliskiren ameliorates tacrolimus-induced nephrotoxicity in rats.

Introduction: Tacrolimus is frequently used as immunosuppressive agent in organ transplantation but its clinical use is limited due to its marked nephrotoxicity.

Materials And Methods: Male Wistar albino rats weighing 150-200 g (10-12 weeks old) were used. Animals were divided into four groups.