Publications by authors named "Khaliah Y Long"
Neurobiol Dis
September 2024
Article Synopsis
- Parkinson's disease (PD) and Dementia with Lewy bodies (DLB) feature harmful protein aggregates called Lewy Pathology, notably in the basolateral amygdala, which affects cognition and emotional processing.
- Research using C57BL/6 J mice injected with α-syn pre-formed fibrils (PFFs) indicates that while synapse loss is minimal, the structure of excitatory synapses in the amygdala changes significantly post-aggregation, increasing their size and volume.
- Additionally, findings suggest that pathological α-syn influences synaptic functioning by altering distances between synaptic vesicles, indicating a link between protein aggregation and synaptic transmission issues.
Article Synopsis
- Parkinson's disease and Dementia with Lewy bodies are linked to the presence of α-synuclein aggregates in the brain, especially in the basolateral amygdala (BLA), which is important for cognition and emotional response.
- In a mouse model, injecting pre-formed α-synuclein fibrils into the brain led to aggregation in the BLA and resulted in impaired contextual fear conditioning and changes in excitatory synaptic transmission.
- The study found that while α-synuclein aggregates did not significantly reduce the number of synapses in the BLA, they altered the morphology of synapses and increased their volume, suggesting significant synaptic architecture changes due to pathologic α-synuclein. *
