Publications by authors named "Khaleel I Alyahya"
Article Synopsis
- The study investigated how different concentrations of interleukin 1 beta (IL-1β) affect the behavior of human bone marrow mesenchymal stem cells (hBM-MSCs) in terms of adhesion, proliferation, and migration.
- Results showed that low concentrations of IL-1β (up to 50 ng/ml) enhanced cell growth and movement, while higher concentrations (100 ng/ml) significantly reduced these activities.
- The study highlights that IL-1β stimulation increases the expression of essential genes related to MSC function, potentially improving their ability to respond to injury in inflamed environments.
We studied the potential of human bone marrow-derived mesenchymal stem cell conditioned media (hBMSC CM) in protecting endothelial cell properties (viability, proliferation, and migrations) from the deleterious effects produced by the inflammatory environment of HO. Additionally, we investigated their impact on the endothelial cells' gene expression of some inflammatory-related genes, namely, TGF-1, FOS, ATF3, RAF-1, and SMAD3. Human umbilical vein endothelial cells (HUVECs) were cultured individually under three conditions: alone, with varying concentrations of HO, or with varying concentrations of HO and hBMSC CM.
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