Publications by authors named "Khaled Zerhouni"

Oxidative stress (OS) is a keystone in the pathology of the ischemia reperfusion sequence (acute coronary syndromes, cardiac surgery, transplantation). In heart failure, the implication of OS is less understood. This study was intended to evaluate OS in acute heart failure.

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Xenotransplantation (XT) reveals a growing interest for the treatment of cardiomyopathy. The major barrier is an acute vascular rejection due to an acute humoral rejection. This pathogenesis is a difficult issue and in order to elaborate means for its prevention, we analysed the implication of oxidative stress (OS) on hearts from mini-pigs followed by reperfusion with either autologous or human blood in an attempt to simulate xenotransplantation.

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Pleural effusions following coronary artery bypass grafting (CABG) have been reported in 65%-89% of the cases. The majority of pleural effusions are left-sided, of little significance, and resolve spontaneously. However, a few pleural effusions require specific therapeutics.

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Introduction: Mediastinal irradiation treatment has drastically improved the prognosis for several neoplasms, mostly particularly breast cancer and lymphoma. Nonetheless, the increase in survival is accompanied by side effects, including cardiac complications that often appear much later.

Case: This patient with Hodgkin disease received radiation therapy.

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Article Synopsis
  • - The study investigates a family with a novel phenotype characterized by severe dilated cardiomyopathy and quadriceps myopathy, revealing an autosomal dominant inheritance pattern.
  • - Physical and neurological examinations of 29 family members found that cardiac issues, including arrhythmias and conduction defects, developed earlier than muscle issues, with a significant portion requiring medical interventions like pacemakers.
  • - Genetic analysis identified a mutation in the lamin A/C gene, linking the observed cardiac and muscle abnormalities to this newly described condition, emphasizing the cardiac issues as crucial for determining prognosis.
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