Publications by authors named "Khaled W Omari"
Article Synopsis
- Diabetes management is crucial, and therapeutic drug monitoring, particularly for medications like metformin and glimepiride, can help maintain optimal dosages in patients.
- A study involving 106 type 2 diabetes patients used a validated LC-MS/MS method to measure drug levels and examined the relationship between drug concentration and genetic mutations, particularly focusing on the SULT1A1 genotype.
- Findings indicated a potential correlation between metformin levels and genetic factors, suggesting that tailored (genotype-guided) drug therapy could enhance treatment effectiveness and reduce adverse effects.
Article Synopsis
- This study focuses on the health concerns related to the leaves of a plant from the Solanaceae family, specifically examining their antioxidant activity and polyphenol content.
- The researchers compared two extraction methods—Methanol-Conventional (MC) and deep eutectic solvents (DES)—and found that the DES method yielded a higher concentration of phenols and flavonoids, as well as more nicotine.
- Despite both extraction methods showing weak antioxidant activity, the DES method demonstrated superior efficiency and environmental benefits for extracting bioactive compounds from the plant.
Plant extracts and their individual components have been used to manage skin aging for several decades. Recently, the discovery of new natural bioactive agents, that not only enhance the skin health but also offer protection against various deleterious factors, such as free radicals, ultraviolet radiation, and microbial infections, has been a potential target by many researchers. The aim of the current work was to investigate the phytochemical profile of an ethanol bark extract from , and to evaluate its antioxidant, antiaging and antibacterial activities .
View Article and Find Full Text PDFObjective: Graviola is a tropical fruit with medicinal properties, used for treating various diseases such as inflammation, diabetes, and cancer. Histone deacetylase inhibitors (HDACIs), including carbamazepine (CBZ) and valproic acid (VPA), have been proven strong inhibitors against cancer cell growth. This study investigated the effect of Graviola fruit extract (GFE) on CBZ in healthy rat plasma using high-performance liquid chromatography (HPLC).
View Article and Find Full Text PDFBenzene, toluene, ethylbenzene, and xylene isomers (BTEX) are known to affect environmental air and health quality. In this study, the levels of BTEX compounds were determined in indoor air environments during the winter generated by several different heaters: diesel pot-bellied heater with chimney (DH); electric heater (EH); unfluted gas heater (GH); kerosene heater (KH); and wood pot-bellied heater with chimney (WH). The samples were collected using a diffusion passive adsorbent (activated charcoal) and then analyzed by gas chromatography-mass spectrometry (GC-MS).
View Article and Find Full Text PDFAn efficient process for converting N-acetyglucosamine (NAG) into 3-acetamido-5-acetylfuran (3A5AF) is reported. 3A5AF is proposed as an N-containing platform chemical, which contains renewable nitrogen. In the reported method NAG, in the presence of boric acid (B(OH)₃) and sodium chloride (NaCl), produces 58 % yield 3A5AF in dimethylacetamide under microwave irradiation (220 °C, 15 min).
View Article and Find Full Text PDFA simple, rapid, reliable, and low cost one-step extraction method is developed and validated for the determination of nicotine and cotinine in human plasma and urine in smokers using reversed-phase high-performance liquid chromatography (RP-HPLC) and gas chromatography-mass spectrometry (GC-MS). The run times are 16 and 10 min for HPLC and GC-MS, respectively. The method is validated over a wide linear range of 1-5000 ng/mL with correlation coefficients being consistently greater than 0.
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