New substituted pyrazole derivatives targeting COXs as potential safe anti-inflammatory agents.

Everyday studies prove the increasing need for newer and safer agents to control cellular inflammatory response, an underlying cause for the pathophysiology of many other clinical cases. Two newly designed sets of schiff and chlacone substituted pyrazoles were synthesized and evaluated for their anti-inflammatory activities. Most potent representatives were chosen for investigation of ulcerogenic and molecular docking properties The synthesized compounds showed considerable edema inhibition percentage range if compared with celecoxib (13-93% and 58-93%, respectively) at different time intervals.

Anti-inflammatory indomethacin analogs endowed with preferential COX-2 inhibitory activity.

The undeniable indomethacin potency has always suffered serious obstacles such as gastric damage. Continuous attempts to develop potent yet safe indomethacin analogs have never ceased. Herein are new indole derivatives and , which were synthesized via Fisher indole reaction, evaluated for both their anti-inflammatory activities using rat paw edema method and their cyclooxygenase inhibitory activities.

Novel 4-methylsulfonylphenyl derivatives as NSAIDS with preferential COX-2 inhibition.

Aim: There has been an enormous commercial development following the introduction of selective COX-2 inhibitors. Efforts are continuously done to discover efficient and safe COX-2 inhibitors.

Results: A series of 4-methylsulfonylphenyl derivatives was designed, synthesized and screened for preferential inhibition of COX-2 over COX-1 isoforms and in vivo anti-inflammatory activity using the rat paw edema method.