Publications by authors named "Khaled Nour"

Article Synopsis
  • The study aimed to assess how different viscosities of short fiber-reinforced composite resin (SFRC) cores and veneering composite resins affect the fracture strength of direct occlusal veneers.
  • A total of 48 resin dies mimicking a maxillary premolar were created, tested across three core material groups, and further divided by two types of veneering materials.
  • Results showed that having an SFRC core boosted fracture strength, with no significant difference between high and low viscosity cores, and injectable composite resin outperformed packable composite resin in terms of strength.
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Background: Self-assessment is key to improving the quality of work performed by dental professionals. The ability to accurately self-assess has been found to correlate with better clinical performance, making it an important skill for students to master during their dental education. Furthermore, studies conducted in dental schools across the world have shown that lower-performing students tend to overestimate their abilities compared to their peers.

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Coronary artery aneurysm in adults is associated with connective tissue disorders, including Marfan syndrome. Coronary artery aneurysms are at risk for thrombosis, which obstructs coronary flow and thus results in myocardial infarction. We present a case of coronary artery aneurysm thrombosis in a patient with Marfan syndrome who presented with acute coronary syndrome.

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  • The study investigates the effectiveness of two surgical procedures (lunate-capitate fusion and four-corner fusion) for treating advanced wrist injuries known as SNAC II and III, focusing on functional and radiological outcomes and complications.
  • It includes a retrospective analysis of 65 patients who underwent surgery between 2015 and 2024, with a follow-up of at least two years, and compares the outcomes of the two fusion techniques.
  • Results showed that both groups experienced functional improvements post-surgery and had similar average healing times, indicating that both procedures could be effective in addressing SNAC injuries.
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Study Objective: The real-world effectiveness and safety of a 0/1-hour accelerated protocol using high-sensitivity cardiac troponin (hs-cTn) to exclude myocardial infarction (MI) compared to routine care in the United States is uncertain. The objective was to compare a 0/1-hour accelerated protocol for evaluation of MI to a 0/3-hour standard care protocol.

Methods: The RACE-IT trial was a stepped-wedge, randomized trial across 9 emergency departments (EDs) that enrolled 32,609 patients evaluated for possible MI from July 2020 through April 2021.

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The improving ATTENDance (iATTEND) to cardiac rehabilitation (CR) trial tested the hypotheses that hybrid CR (HYCR) (combination of virtual and in-facility CR sessions) would result in greater attendance compared with traditional, facility-based only CR (FBCR) and yield equivalent improvements in exercise capacity and health status. Patients were randomized to HYCR (n = 142) or FBCR (n = 140), stratified by gender and race. Attendance was assessed as number of CR sessions completed within 6 months (primary end point) and the percentage of patients completing 36 CR sessions.

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Article Synopsis
  • The study evaluates the economic impact of an accelerated protocol (AP) for diagnosing myocardial infarction (MI) using high-sensitivity cardiac troponin (hs-cTn) compared to conventional testing methods.
  • Conducted across nine emergency departments, the research analyzed costs and length of stay for nearly 32,450 patients suspected of having MI.
  • Results showed that the AP did not significantly increase treatment costs or length of stay overall, but some lower acuity emergency departments experienced shorter stays and lower health system costs with the AP.
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Background: The Wide-Awake Local Anesthesia No Tourniquet (WALANT) technique allows intraoperative motor assessment of tendon repair integrity of the hand compared with general anesthesia or brachial plexus block. No studies have tested the effect of adding dexmedetomidine to lidocaine on the analgesic properties of the WALANT technique, which is the aim of our study.

Methods: A total of 128 patients aged more than 18 years were scheduled for surgical flexor tendon injury repair using WALANT technique.

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  • Global longitudinal strain (GLS) is a useful tool for detecting hidden heart problems in patients with obstructive coronary artery disease (CAD), but its relationship with ischemia in those with myocardial ischemia and no obstructive CAD (INOCA) is less understood.
  • A study analyzed GLS in patients with INOCA using stress echocardiography, revealing that the majority had normal GLS values both at enrollment and after one year, but these values did not correlate with stress-induced ischemia.
  • The findings suggest that in INOCA patients, normal GLS does not indicate the presence or severity of ischemia, indicating a need for alternative assessment methods for myocardial dysfunction in this group.
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This study evaluated the interfacial integrity of deep (6 mm) Class-II (OM/OD) restorations placed using different bulk-fill resin composites [Filtek™ Bulk Fill Flowable Restorative (BF) and Filtek™ Bulk Fill Posterior Restorative (BP) (3M ESPE, St. Paul, MN, USA)] of different increment thicknesses (2 or 4 mm). BP was used for capping in all cases, while Filtek™ Z250 Universal Restorative (3M ESPE) was used as the control material.

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  • Chronic kidney disease (CKD) increases the risk of complications after percutaneous coronary intervention (PCI), and it's unclear how genetic factors like CYP2C19 loss of function (LOF) alleles affect this risk or the safety of genotype-guided therapy.
  • A study with 5,815 patients analyzed outcomes based on CKD status and found no significant interaction between treatment strategy and CKD for major cardiovascular events or bleeding risks after 12 months.
  • The findings suggest that while escalating P2Y inhibitor therapy via a genotype-guided approach doesn't reduce complications in CKD patients, it also doesn't increase bleeding risks, indicating the need for larger studies to confirm these results.
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Article Synopsis
  • Ischemia without obstructive coronary artery disease (INOCA) is a common condition that carries a poor prognosis, and this study aimed to understand its natural progression and related symptoms.
  • The CIAO-ISCHEMIA study assessed angina and stress echocardiography results in patients with INOCA over a year, highlighting the relationship between angina severity and ischemia.
  • Findings indicated that although INOCA participants were mostly female and had similar ischemia levels to those with coronary artery disease, there was little correlation between changes in angina and ischemia over the year.
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Objective: To investigate the relationship between maximal exercise capacity measured before severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and hospitalization due to coronavirus disease 2019 (COVID-19).

Methods: We identified patients (≥18 years) who completed a clinically indicated exercise stress test between January 1, 2016, and February 29, 2020, and had a test for SARS-CoV-2 (ie, real-time reverse transcriptase polymerase chain reaction test) between February 29, 2020, and May 30, 2020. Maximal exercise capacity was quantified in metabolic equivalents of task (METs).

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Objective: Cerebrovascular injury (CVI) is a recognized but underappreciated complication of acute type B aortic dissection (ATBAD). This study was performed to determine risk factors for CVI associated with ATBAD and, in particular, the possible contributory role of aggressive anti-impulse therapy.

Methods: A retrospective review of all patients presenting to a tertiary medical center with an ATBAD between January 2003 and October 2012 was conducted.

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Background: Long standing nonunion of the lateral humeral condyle (LHC) usually results in elbow pain and instability with progressive cubitus valgus and tardy ulnar neuritis. Surgical treatment of long standing nonunion is still a controversial issue due to the reported complications, such as stiffness, loss of elbow motion, and avascular necrosis of the LHC fragment. In this study, we reported the outcomes of treatment of cubitus valgus deformity in long standing nonunion of the LHC in children treated with combined triple management (fixation of the nonunion site, dome corrective osteotomy, and anterior transposition of ulnar nerve) through a modified para-triceptal approach.

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Background: Observation units (OUs) may be an efficient and effective setting to diagnose and risk stratify patients with coronary ischemia and myocardial infarction (MI). Given improved cardiac troponin I (cTnI) assays and expanded utilization of OUs, it is not uncommon for patients with mildly elevated cTnI to be evaluated in OUs. We investigated the serial cTnI results in OU patients to determine whether absolute or relative cTnI changes were useful for the diagnosis of MI.

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Objective: The effect of socioeconomic status (SES) on the course of many disease states has been documented in the literature but has not been studied in aortic dissection. This study evaluated the effect of SES on 30-day and long-term survival of patients after aortic dissection.

Methods: Hospital discharge records were used to identify patients with acute aortic dissection.

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The purpose of this retrospective, observational study was to describe the relation between exercise workload during cardiac rehabilitation (CR), expressed as metabolic equivalents of task (METs), and prognosis among patients with coronary heart disease. We included patients with coronary heart disease who participated in CR between January 1998 and June 2007. METs were calculated from treadmill workload.

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We report our identification of a single coronary ostium arising from the right coronary sinus of Valsalva, in a 63-year-old woman who presented with chest pain atypical of angina. Coronary angiograms showed that the left anterior descending coronary artery arose from a right ventricular branch and that the left circumflex coronary artery arose from a right posterolateral branch. Both arteries reconstituted themselves in a backward fashion from the apex to the base of the heart-a configuration that to our knowledge has not been reported.

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Background: The purpose of this study was to assess whether delayed enhancement (DE) on MRI is associated with ventricular tachycardia (VT)/ventricular fibrillation or death in patients with cardiac sarcoidosis and left ventricular ejection fraction >35%.

Methods And Results: Fifty-one patients with cardiac sarcoidosis and left ventricular ejection fraction >35% underwent DE-MRI. DE was assessed by visual scoring and quantified with the full-width at half-maximum method.

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Background: We hypothesized that the severity of resting perfusion abnormalities assessed by the summed rest score (SRS) would be associated with a higher rate of adverse outcomes in patients with heart failure (HF) and reduced left ventricular (LV) ejection fraction (EF).

Methods: A subset of 240 subjects from HF-ACTION underwent resting technetium-99m tetrofosmin-gated single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). Images were evaluated using a 17-segment model to derive the SRS and additional nuclear variables.

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Background: There are currently limited data on the relationships between resting perfusion abnormalities, left ventricular ejection fraction (LVEF), New York Heart Association (NYHA) functional class, and exercise capacity as defined by peak VO(2) and 6-minute walk test in patients with heart failure (HF) and reduced LVEF. Furthermore, the association between resting perfusion abnormalities and left ventricular dyssynchrony is currently unknown. This article addresses the Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION) gated SPECT imaging (gSPECT) substudy baseline results.

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Endothelin 1 mediates coronary vasoconstriction and endothelial dysfunction via endothelin receptor type A (ET(A)) activation. However, the effects of selective endothelin receptor type B (ET(B)) and combined ET(A+B) receptor blockade on coronary vasomotion are unknown. We measured coronary vascular tone and endothelium-dependent and -independent vasomotor function before and after selective infusion of BQ-788 (an ET(B) receptor antagonist) or combined infusion of BQ-788+BQ-123 (an ET(A) antagonist) into unobstructed coronary arteries of 39 patients with coronary atherosclerosis or risk factors undergoing cardiac catheterization.

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