Analyte protectant approach to protect amide-based synthetic cannabinoids from degradation and esterification during GC-MS analysis.

The forensic analysis of amide-based synthetic cannabinoids (SCs) in seized materials is routinely performed using gas chromatography-mass spectrometry (GC-MS); however, a major challenge associated with GC-MS is the thermolytic degradation of substances with sensitive functional groups. Herein, we report the comprehensive thermal degradation and ester transformation of amide-based SCs, such as AB-FUBINACA, AB-CHMINACA, and MAB-CHMINACA, during GC-MS analysis and their treatment with analyte protectants (APs). These SCs were found to undergo thermolytic degradation during GC-MS in the presence of non-alcohol solvents.

Toxic effects of AB-CHMINACA on liver and kidney and detection of its blood level in adult male mice.

Background: AB-CHMINACA is a cannabimimetic indazole derivative. In 2013, it was reported in different countries as a substance of abuse.

Purpose: This study evaluated the subacute toxic effects of AB-CHMINACA on the liver and kidneys and measured its blood level in adult male mice.