Homozygous deletion of the FHIT gene, p21WAF1 protein expression and apoptosis in bilharzial bladder cancer.

The FHIT gene alterations may occur as early consequences for the urinary bladder cancer. The present study aimed to identify and analyze the role of homozygous deletion (HZD) and transcriptional alterations of fragile histidine triad (FHIT) gene in the development and progression of bilharzial bladder cancer in Egyptian patients. The possible associations between FHIT abnormalities and some clinical variables that have prognostic impact in bilharzial bladder cancer patients were determined.