Headspace aroma and secondary metabolites profiling in 3 Pelargonium taxa using a multiplex approach of SPME-GC/MS and high resolution-UPLC/MS/MS coupled to chemometrics.

Background: The present study focuses on the aroma and secondary metabolites profiling of three Pelargonium graveolens cultivars, baladi (GRB), sondos (GRS) and shish (GRSH), grown in Egypt. Utilizing a multiplex approach combining high resolution-ultraperformance liquid chromatography (HR-UPLC)/tandem mass spectrometry (MS/MS) and gas chromatography (GC)-MS coupled with chemometrics, the study aims to identify and profile various secondary metabolites and aroma compounds in these cultivars.

Results: HR-UPLC/MS/MS analysis led to the annotation of 111 secondary metabolites, including phenolics, flavonoids, terpenes and fatty acids, with several compounds being reported for the first time in geranium.

Investigating the promising SARS-CoV-2 main protease inhibitory activity of secoiridoids isolated from ; and assessments with structure-activity relationship.

The proteolytic enzyme 3 C-like protease (3Clpro or M) is considered the most important target for SARS-CoV-2 which could be attributed to its crucial role in viral maturation and/or replication. Besides, natural phytoconstituents from plant origin are always promising lead compounds in the drug discovery area. Herein, the previously isolated and identified seven compounds from () were examined and against the SARS-CoV-2 M.

Cytotoxic effects of extracts obtained from plants of the Oleaceae family: bio-guided isolation and molecular docking of new secoiridoids from .

Context: Traditionally, Oleaceae plants are used to treat many diseases, such as rheumatism, hypercholesterolaemia, or ulcers.

Objectives: To investigate the cytotoxic potential of L., L.

Nanoemulsions of L. and L. Essential Oils: An Approach to Enhance Their Cytotoxic and Antiviral Effects.

Unprecedented nanoemulsion formulations (NE) of and essential oils (EO) were prepared, and examined for their cytotoxic and antiviral activities. NE characterization and stability examination tests were performed to ensure formula stability. The antiviral activity was determined against hepatitis A (HAV) and herpes simplex type-1 (HSV-1) viruses using MTT assay, while the cytotoxic potential was determined against liver (HepG-2), breast (MCF-7), leukemia (THP-1) cancer cell lines and normal Vero cells.

High-Resolution UPLC-MS Profiling of Anthocyanins and Flavonols of Red Cabbage ( L. var. f. DC.) Cultivated in Egypt and Evaluation of Their Biological Activity.

In this paper, biological investigations and a high-resolution UPLC-PDA-ESI-qTOF-HRMS technique were employed for L. var. f.