Publications by authors named "Khaled A Sedeek"
Article Synopsis
- Researchers studied rare genetic variants related to platelet function to understand their link to ischemic stroke (IS) in Polish patients.
- They analyzed 26 genes associated with platelet surfaces by re-sequencing the DNA of 1,000 individuals (500 with IS and 500 controls).
- The study found six damaging rare variants associated with the susceptibility to IS, suggesting that these variants play a significant role in platelet reactivity and stroke risk.
Background: Pressure control ventilation (PCV), high-frequency oscillation (HFO), and intratracheal pulmonary ventilation (ITPV) may all be used to provide lung protective ventilation in acute respiratory distress syndrome, but the specific approach that is optimal remains controversial.
Methods: Saline lavage was used to produce acute respiratory distress syndrome in 21 sheep randomly assigned to receive PCV, HFO, or ITPV as follows: positive end-expiratory pressure (PCV and ITPV) and mean airway pressure (HFO) were set in a pressure-decreasing manner after lung recruitment that achieved a ratio of Pao2/Fio2 > 400 mmHg. Respiratory rates were 30 breaths/min, 120 breaths/min, and 8 Hz, respectively, for PCV, ITPV, and HFO.
Objective: High-frequency oscillation has been proposed for use in adult acute respiratory distress syndrome. However, limited data are available on the effect of pressure amplitude and rate (Hz) on tidal volumes delivered during high-frequency oscillation in adults.
Design: Prospective, animal model, lung injury study.