Scientometric analysis of trends in global research on acne treatment.

Unlabelled: Acne or acne vulgaris is the most common chronic inflammatory disease of the sebaceous follicles.

Objectives: The present study aims to identify the main lines of research in the field of acne treatment using reproducible scientometric methods. In this article, we reviewed the following research trends: facial acne, different antibiotics, retinoids, anti-inflammatory drugs, epidermal growth factor receptor inhibitors therapy, and associated diseases.

How Do COVID-19 Risk, Life-Safety Risk, Job Insecurity, and Work-Family Conflict Affect Miner Performance? Health-Anxiety and Job-Anxiety Perspectives.

The coronavirus pandemic (COVID-19) has created challenging working conditions in coal-production activities. In addition to the massive loss of resources for miners, it has had a devastating impact on these individuals' mental health. Based on the conservation of resources (COR) theory and a resource-loss perspective, this study examined the impact of COVID-19 risk, life-safety risk, perceived job insecurity, and work-family conflict on miners' job performance.

[Cerebral venous thrombosis].

Cerebral venous thrombosis (CVT) is one of the rare causes of stroke. It can manifest itself in different symptoms, making its timely diagnostics greatly complicated. Early recognition of symptoms and correct treatment tactics improve the prognosis in these patients.

Neuroinflammation and Neuropathology.

This review addresses the current understanding of the role of autoimmune neuroinflammation in the pathogenesis of vascular, neurodegenerative, and other diseases of the nervous system. The mechanisms of responses of resident CNS cells (glial cells, astrocytes) and peripheral immune system cells are presented. The therapeutic potentials of phosphodiesterase inhibitors, which have antiaggregant properties and can suppress autoimmune inflammation, are discussed.

Global interest in vaccines during the COVID-19 pandemic: Evidence from Google Trends.

COVID-19 (coronavirus disease 2019) vaccines have become available; now, everyone has the opportunity to get vaccinated. We used Google Trends (GT) data to assess the global public interest in COVID-19 vaccines during the pandemic. For the analysis, a period of 17 months was chosen (from Jan 19, 2020, to Jul 04, 2021).

A Smart Healthcare Knowledge Service Framework for Hierarchical Medical Treatment System.

This paper reveals the research hotspots and development directions of case-based reasoning in the field of health care, and proposes the framework and key technologies of medical knowledge service systems based on case-based reasoning (CBR) in the big data environment. The 2124 articles on medical CBR in the Web of Science were visualized and analyzed using a bibliometrics method, and a CBR-based knowledge service system framework was constructed in the medical Internet of all people, things and data resources environment. An intelligent construction method for the clinical medical case base and the gray case knowledge reasoning model were proposed.

An Adaptive Deep Ensemble Learning Method for Dynamic Evolving Diagnostic Task Scenarios.

Increasingly, machine learning methods have been applied to aid in diagnosis with good results. However, some complex models can confuse physicians because they are difficult to understand, while data differences across diagnostic tasks and institutions can cause model performance fluctuations. To address this challenge, we combined the Deep Ensemble Model (DEM) and tree-structured Parzen Estimator (TPE) and proposed an adaptive deep ensemble learning method (TPE-DEM) for dynamic evolving diagnostic task scenarios.

CGRdb2.0: A Python Database Management System for Molecules, Reactions, and Chemical Data.

This work introduces CGRdb2.0─an open-source database management system for molecules, reactions, and chemical data. CGRdb2.

Global Scientific Research on SARS-CoV-2 Vaccines: A Bibliometric Analysis.

Objective: We performed this bibliometric analysis to identify global scientific research on the SARS-CoV-2 vaccines.

Materials And Methods: This bibliometric analysis study inclusive search of English-language publications related to the SARS-CoV-2 vaccines was conducted in the Scopus, PubMed, and Dimensions databases without year limitations. The results of bibliometric analysis comprised a time-dependent citation density trend, the name of the journal, journal impact factor (IF), year of publication, type of article, category, subscription or affiliation, co-authorship, and cooccurrence network.

Immunomodulatory effect of the combined use of Vetosporin Zh probiotic and Gumi-malysh biologically active additive.

Background And Aim: Various means and methods, including probiotics and biologically active additives, have been developed and proposed for production to increase the immunobiological reactivity of the body, regardless of the etiology of its decrease. This study aimed to find out the immune status of calves during the preweaning period in association with Vetosporin Zh, Normosil, and Gumi-malysh.

Materials And Methods: The research object was 30-day-old calves of black-and-white Holstein breed.

[Neuroinflammation and neuropathology].

The review highlights the current understanding of the role of autoimmune neuroinflammation in the pathogenesis of vascular, neurodegenerative and other diseases of the nervous system. The mechanisms of the response of the resident cells of the central nervous system (microglia, astrocytes) and peripheral cells of the immune system are considered. Possible therapeutic potential of phosphodiesterase inhibitors, which have antiplatelet properties and the ability to suppress autoimmune inflammation, are outlined.

Tracking Knowledge Evolution Based on the Terminology Dynamics in 4P-Medicine.

The accelerating evolution of scientific terms connected with 4P-medicine terminology and a need to track this process has led to the development of new methods of analysis and visualization of unstructured information. We built a collection of terms especially extracted from the PubMed database. Statistical analysis showed the temporal dynamics of the formation of derivatives and significant collocations of medical terms.

[Central Sensitization Inventory - a Russian version].

Objective: To develop and validate a Russian version of The Central Sensitization Inventory (CSI-R).

Material And Methods: The study included 3 stages: 1) direct and reverse translation, linguistic validation of the questionnaire; 2) assessment of internal consistency, reliability and sensitivity (=50); 3) psychometric validation in the samples of patients with fibromyalgia syndrome (=40), chronic widespread pain (=40), regional chronic low back pain without other specific pain complaints (=40), and in the control sample of informants with no pain complaints (=40).

Results And Conclusion: The Russian version of CSI-R is valid, reliable and can be used in clinical practice as a diagnostic tool for revealing central sensitization.

[Stress-induced disorders].

The review analyses the diseases and conditions caused by acute and chronic stress. The authors describe the pathogenesis of stress-induced disorders from the perspective of imbalance between stress-realizing and stress-limiting systems (sympathetic and parasympathetic nervous systems). The effects of acute and chronic stress on the cardiovascular, respiratory, and immune systems, the contribution of stress to the pathogenesis of skin diseases, the gastrointestinal tract, post-stroke disorders, headaches, and dizziness are considered.

Correction: Kutlushina, A., et al. Ligand-Based Pharmacophore Modeling Using Novel 3D Pharmacophore Signatures. Molecules, 2018, 23, 3094.

The authors would like to add the funding number to the published article [...

Ligand-Based Pharmacophore Modeling Using Novel 3D Pharmacophore Signatures.

Pharmacophore modeling is a widely used strategy for finding new hit molecules. Since not all protein targets have available 3D structures, ligand-based approaches are still useful. Currently, there are just a few free ligand-based pharmacophore modeling tools, and these have a lot of restrictions, e.

[Spinal segmental myoclonus in multiple sclerosis (case report)].

Multiple sclerosis (MS) is a disease with multicentric lesions of central nervous system. These numerous lesions can cause a lot of different symptoms. Sometimes these signs are atypical and make difficulties for MS diagnosing.

[The chronic form of tick-born encephalitis with a clinical manifestation of disseminated encephalomyelitis (case description)].

In most cases, the chronic form of tick-born encephalitis (CTBE) develops after the acute phase of the disease and is characterized by polymorphic clinical manifestations. It is not often to see patients with disseminated encephalomyelitis in case of CTBE. We describe a patient with CTBE developed 12 years after the acute phase of the disease, which had a remitting course and clinically revealed multifocal lesions.

[An NMR study of the temperature dependence of the coefficient of water self-diffusion through lipid bilayer membranes].

The temperature dependence of the coefficient of water self-diffusion through plane-parallel lipid multilayers of the phospholipid dioleoylphosphatidylcholine oriented on a glass support has been studied in the temperature range of 20-60 degrees C by the method of NMR with magnetic field pulse gradient. The values of the coefficients of transbilayer water diffusion are by four orders of magnitude less than for bulky water and ten times less than the coefficients of lateral diffusion of the lipid under the same conditions. The temperature dependence of the coefficient of water diffusion is described by the Arrhenius law with an apparent activation energy of about 41 kJ/mol, which far exceeds the activation energy for the diffusion of bulky water (18 kJ/mol).

[Interaction between glycogen phosphorylase b and creatinine kinase from rabbit skeletal muscle].

Phosphorylase b association with creatine kinase has been studied by frontal elution affinity chromatography, using CNBr-Sepharose 4B immobilized creatine kinase as the affinity matrix. The quantitative parameters of this interaction were estimated from the volumes of phosphorylase b elution at various concentrations of the enzyme. The dissociation constants for phosphorylase b complexes with immobilized creatine kinase and of the phosphorylase b complex with free creatine kinase were found to be equal to 0.