Decoherence of photon entanglement by transmission through brain tissue with Alzheimer's disease.

The generation, manipulation and quantification of non-classical light, such as quantum-entangled photon pairs, differs significantly from methods with classical light. Thus, quantum measures could be harnessed to give new information about the interaction of light with matter. In this study we investigate if quantum entanglement can be used to diagnose disease.

Multimodal imaging system combining optical coherence tomography and Brillouin microscopy for neural tube imaging.

To understand the dynamics of tissue stiffness during neural tube formation and closure in a murine model, we have developed a multimodal, coaligned imaging system combining optical coherence tomography (OCT) and Brillouin microscopy. Brillouin microscopy can map the longitudinal modulus of tissue but cannot provide structural images. Thus, it is limited for imaging dynamic processes such as neural tube formation and closure.

Multimodal high-resolution embryonic imaging with light sheet fluorescence microscopy and optical coherence tomography.

A high-resolution imaging system combining optical coherence tomography (OCT) and light sheet fluorescence microscopy (LSFM) was developed. LSFM confined the excitation to only the focal plane, removing the out of plane fluorescence. This enabled imaging a murine embryo with higher speed and specificity than traditional fluorescence microscopy.

Multitwist Möbius Strips and Twisted Ribbons in the Polarization of Paraxial Light Beams.

The polarization of light can exhibit unusual features when singular optical beams are involved. In 3-dimensional polarized random media the polarization orientation around singularities describe 1/2 or 3/2 Möbius strips. It has been predicted that if singular beams intersect non-collinearly in free space, the polarization ellipse rotates forming many-turn Möbius strips or twisted ribbons along closed loops around a central singularity.

Monstar polarization singularities with elliptically-symmetric q-plates.

Space-variant polarization patterns present in the transverse mode of optical beams highlight disclination patterns of polarization about a singularity, often a C-point. These patterns are important for understanding rotational dislocations and for characterizing complex polarization patterns. Liquid-crystal devices known as q-plates have been used to produce two of the three types of disclination patterns in optical beams: lemons and stars.

Determining topological charge of an optical beam using a wedged optical flat.

The topological charge of a beam carrying an optical vortex is an important parameter that specifies the amount of orbital angular momentum carried by the beam and the azimuthal order of the beam mode. We present an experimental method to determine the sign and magnitude of the topological charge using a wedged optical flat as a lateral shearing interferometer. When the curvature of the wavefront is adjusted to be planar, the fringe pattern generated by the shearing interferometer consists of two conjoined forks that unambiguously identify the topological charge of the beam.

Monstar disclinations in the polarization of singular optical beams.

The control of spatial and polarization modes of optical beams enables the production of topological singularities encoded on the polarization of the light. This allows the study of topological disclinations not easily found in the natural setting. In this article we report on the observation of new features in disclinations realized with singular optical beams.