Publications by authors named "Khairunnisa Mohd Kamal"
Article Synopsis
- Lung cancer, specifically non-small cell lung cancer (NSCLC), is a major global health issue with rising cases and limited treatment options largely due to its connection with tobacco and the complexity of its subtypes.
- The role of epigenetics, particularly DNA methylation and its regulation by the enzyme DNA methyltransferases (DNMTs), is gaining attention in understanding and managing lung cancer.
- Abnormal patterns in DNMTs can disrupt gene regulation in cancer cells, and current research is exploring these patterns as potential diagnostic and therapeutic targets to improve outcomes for NSCLC patients.
The pentose phosphate pathway (PPP) plays a key role in many metabolic functions, including the generation of NADPH, biosynthesis of nucleotides, and carbon homeostasis. In particular, the intermediates of PPP have been found to be significantly perturbed in bacterial metabolomic studies. Nonetheless, detailed analysis to gain mechanistic information of PPP metabolism remains limited as most studies are unable to report on the absolute levels of the metabolites.
View Article and Find Full Text PDFMetabolomics is a comprehensive analysis of metabolites existing in biological systems. As one of the important "omics" tools, the approach has been widely employed in various fields in helping to better understand the complex cellular metabolic states and changes. Bacterial metabolomics has gained a significant interest as bacteria serve to provide a better subject or model at systems level.
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