Publications by authors named "Khairil K Zulkifli"
Contemporary systems for the diagnosis and management gastrointestinal symptoms not attributable to organic diseases (Functional GI Disorders, FGID, now renamed Disorders of Gut-Brain Interaction, DGBI) seek to categorize patients into narrowly defined symptom-based sub-classes to enable targeted treatment of patient cohorts with similar underlying putative pathophysiology. However, an overlap of symptom categories frequently occurs and has a negative impact on treatment outcomes. There is a lack of guidance on their management.
View Article and Find Full Text PDFDigestive disorder symptoms in COVID-19 may be similar in form to post-infectious functional gastrointestinal disorder (PI-FGID). To cause clinical effects, SARS-CoV-2 must reach the bowels and gastric hypochlorhydria may facilitate such transit. Asian elderly are predisposed to greater infection rate and severity of COVID-19, and the high prevalence of gastric atrophy and intake of proton-pump inhibitor in this aged group might explain the risk.
View Article and Find Full Text PDFArticle Synopsis
- Dysglycemia is common in patients with chronic obstructive pulmonary disease (COPD) but is often undiagnosed, leading to a study to assess its prevalence and related factors among these patients.
- The study included 186 adults with established COPD and found that 16 had diabetes and 32 had prediabetes after an oral glucose tolerance test, with higher incidences of newly diagnosed dysglycemia.
- Key predictors for dysglycemia were identified as cumulative hospital admission days (≥6 days/year) and weight (≥65 kg), highlighting the need for better screening in COPD patients, especially those with frequent acute exacerbations.
Introduction: Small intestinal bacterial overgrowth (SIBO) is prevalent in irritable bowel syndrome (IBS), but its' association with other functional gastrointestinal disorders (FGIDs) is less certain. This study aimed to explore SIBO in a multi-racial Asian population with various FGIDs compared to non-FGID controls.
Methodology: Consecutive Asian adults with Rome III diagnosed common FGIDs (functional dyspepsia/FD, IBS and functional constipation/FC) and non-FGID controls were subjected to glucose breath testing, with hydrogen (H2) and methane (CH4) levels determined.
Background: Health management strategies may help patients with abdominal bloating (AB), but there are currently no tools that measure behaviour and awareness. This study aimed to validate and verify the dimensionality of the newly-developed Health Promoting Behaviour for Bloating (HPB-Bloat) scale.
Methods: Based on previous literature, expert input, and in-depth interviews, we generated new items for the HPB-Bloat.