[Problems in the treatment of peritonitis].

The spreaded purulent peritonitis can not be separated from abdominal sepsis. There were enlighted the unsolved problems of peritonitis treatment, including the patient's state severity estimation, indications for the staged programmed sanation relaparotomy performance and the abdominal cavity drainage methods.

[The ratio of nosological forms and surgical tactics in the treatment of the thyroid gland diseases].

The dynamics of morphofunctional changes of the thyroid gland tissue was analyzed in patients with the organ diseases in 1995-2003. It was established, that geochemical environmental factors constitute the cause of the nodous goiter occurrence. The environment soiling causes the thyroid gland tissue dysplasia and the cancer occurrence.

[Apparatuses for the wound closure in modern surgical practice].

The method of the wounds treatment, using apparatuses for their edges rapprochement, was elaborated, basing on analysis of clinico-experimental investigations conducted. The method was successfully applied for the wounds closure after excision of coccygeal channel, the soft tissues abscess and phlegmon, postoperative ligature fistula and in temporary closure of laparotomy wound in patients with purulent peritonitis.

[Application of plasmapheresis in complex of preoperative preparation in patients with autoimmune thyroiditis and diffuse toxic goiter].

The article is devoted to actulal problem of endocrinology and surgery-treatment of severe diseases of the thyroid gland. Results of plasmapheresis application in complex preoperative preparation in 90 patients, aged from 20 to 60 yrs, in severe course of the disease, were adduced. After plasmapheresis preparation conduction the reduction of the autoimmune processes in the patients organisms, the antibodies titer lowering were noted, witnessing the stable remission achievement.

[Ultrastructural changes in gastroduodenal mucosal cells in patients with perforating ulcer and effect of serotonin adipinate on their postoperative rehabilitation].

Consideration is given in the paper to the state of the mucosal cell ultrastructure in the gastroduodenal zone in patients with perforating ulcer. Apparent inflammatory-degenerative type ultrastructural alterations have been found to be precent in the gastric and duodenal mucous coat in the zone of perforating ulcer. The above alterations are noted to persist by day 10 in these postsurgical patients having been administered conventional treatments.

[Influence of surgical intervention on reactivity of organism of patients with perforative gastroduodenal ulcer].

Influence of operative intervention of various kinds on state of cellular and humoral immunity was studied in 49 patients with perforative gastroduodenal ulcer. The immunity indexes in patients constitute the prognostic test for estimation of the disease course severity and postoperative therapy efficacy. Significant lowering of postoperative complications frequency was promoted by application of preparations, stimulating the immune system (metrogyl, tactivin, gamma-globulins) in patients after the operation.

[Treatment of perforated gastroduodenal ulcers].

Results of treatment of 751 patients with perforated gastroduodenal ulcers are analyzed. In addition to routine tests, ultrasonography, computed tomography and laparoscopy were used to diagnose difficult cases. The optimum surgical aids are chosen by taking into account the interval between the onset of perforation and admission, a history of peptic ulcerous, the pattern of peritonitis, age, comorbidity, and surgical findings.

Microcirculatory disturbances in gastric mucosa during ulcer disease and effects of serotonin on their dynamics.

Experiments on rat model of stress-induced gastric ulcers revealed marked circulatory disturbances in ulcerated gastric mucosa associated with arteriolar spasm and venous congestion and leading to perivascular edema, diapedesis of erythrocytes, and microhemorrhages. These changes were most pronounced on day 1 after ulcer modeling and progressively decreased during healing (day 14-21). On day 3, arterial hyperemia developed against the background of venous congestion, which was probably related to progressive repair.