Acceptance of peer physical examination in medical students in Wuhan, China: A cross-sectional study.

Background: Peer physical examination (PPE) is an essential part of the education of medical students. This study aimed to assess the acceptance level of PPE in Chinese society as well as other related factors. While there have been numerous studies on PPE acceptance in Western societies, there have been relatively few studies on this topic in China.

Application of Distributed Optical Fiber Sensing Technology to the Detection and Monitoring of Internal Swelling Pathologies in Massive Concrete Blocks.

This paper presents an experimental application of Distributed Optical Fiber Sensors (DOFS) for the Structural Health Monitoring (SHM) of concrete structures affected by internal swelling pathologies. In the framework of a large research project aiming to assess the possible extension of the operating lifetime of nuclear power plants from 40 to 60 years, massive blocks were cast from reactive concrete mixtures intended to develop delayed ettringite formation and alkali-silica reaction. These blocks were subjected to specific ageing conditions to initiate and accelerate the concrete pathologies.

The Small GTPase RHOA Links SLP65 Activation to PTEN Function in Pre B Cells and Is Essential for the Generation and Survival of Normal and Malignant B Cells.

The generation, differentiation, survival and activation of B cells are coordinated by signals emerging from the B cell antigen receptor (BCR) or its precursor, the pre-BCR. The adaptor protein SLP65 (also known as BLNK) is an important signaling factor that controls pre-B cell differentiation by down-regulation of PI3K signaling. Here, we investigated the mechanism by which SLP65 interferes with PI3K signaling.

B-cell antigen receptor expression and phosphatidylinositol 3-kinase signaling regulate genesis and maintenance of mouse chronic lymphocytic leukemia.

Chronic lymphocytic leukemia (CLL) is a frequent lymphoproliferative disorder of B cells. Although inhibitors targeting signal proteins involved in B-cell antigen receptor (BCR) signaling constitute an important part of the current therapeutic protocols for CLL patients, the exact role of BCR signaling, as compared to genetic aberration, in the development and progression of CLL is controversial. In order to investigate whether BCR expression per se is pivotal for the development and maintenance of CLL B cells, we used the TCL1 mouse model.

Environmental Durability of an Optical Fiber Cable Intended for Distributed Strain Measurements in Concrete Structures.

The present study investigates the environmental durability of a distributed optical fiber sensing (DOFS) cable on the market, commonly used for distributed strain measurements in reinforced concrete structures. An extensive experimental program was conducted on different types of specimens (including samples of bare DOFS cable and plain concrete specimens instrumented with this DOFS cable) that were exposed to accelerated and natural ageing (NA) conditions for different periods of up to 18 months. The instrumentation of both concrete specimens consisted of DOFS cables embedded at the center of the specimens and bonded at the concrete surface, as these two configurations are commonly deployed in the field.

Defective Allelic Exclusion by IgD in the Absence of Autoantigen.

A considerable proportion of peripheral B cells is autoreactive, and it is unclear how the activation of such potentially harmful cells is regulated. In this study, we show that the different activation thresholds or IgM and IgD BCRs adjust B cell activation to the diverse requirements during development. We rely on the autoreactive 3-83 model BCR to generate and analyze mice expressing exclusively autoreactive IgD BCRs on two different backgrounds that determine two stages of autoreactivity, depending on the presence or absence of the cognate Ag.

Experimental and Numerical Investigation on the Strain Response of Distributed Optical Fiber Sensors Bonded to Concrete: Influence of the Adhesive Stiffness on Crack Monitoring Performance.

The present study investigated the strain response of a distributed optical fiber sensor (DOFS) sealed in a groove at the surface of a concrete structure using a polymer adhesive and aimed to identify optimal conditions for crack monitoring. A finite element model (FEM) was first proposed to describe the strain transfer process between the host structure and the DOFS core, highlighting the influence of the adhesive stiffness. In a second part, mechanical tests were conducted on concrete specimens instrumented with DOFS bonded/sealed using several adhesives exhibiting a broad stiffness range.

Synergism between IL7R and CXCR4 drives BCR-ABL induced transformation in Philadelphia chromosome-positive acute lymphoblastic leukemia.

Ph acute lymphoblastic leukemia (ALL) is characterized by the expression of an oncogenic fusion kinase termed BCR-ABL1. Here, we show that interleukin 7 receptor (IL7R) interacts with the chemokine receptor CXCR4 to recruit BCR-ABL1 and JAK kinases in close proximity. Treatment with BCR-ABL1 kinase inhibitors results in elevated expression of IL7R which enables the survival of transformed cells when IL7 was added together with the kinase inhibitors.

Finer SHM-Coverage of Inter-Plies and Bondings in Smart Composite by Dual Sinusoidal Placed Distributed Optical Fiber Sensors.

Designing of new generation offshore wind turbine blades is a great challenge as size of blades are getting larger (typically larger than 100 m). Structural Health Monitoring (SHM), which uses embedded Fiber Optics Sensors (FOSs), is incorporated in critical stressed zones such as trailing edges and spar webs. When FOS are embedded within composites, a 'penny shape' region of resin concentration is formed around the section of FOS.

Differences in Self-Recognition between Secreted Antibody and Membrane-Bound B Cell Antigen Receptor.

The random gene segment rearrangement during B cell development ensures Ab repertoire diversity. Because this process might generate autoreactive specificities, it has been proposed that stringent selection mechanisms prevent the development of autoreactive B cells. However, conventional assays to identify autoreactive B cells usually employ in vitro-generated Abs, which differ from membrane-bound BCRs.

PI3K-Mediated Blimp-1 Activation Controls B Cell Selection and Homeostasis.

Activation of phosphoinositide 3-kinase (PI3K) signaling plays a central role in regulating proliferation and survival of B cells. Here, we tested the hypothesis that B cell receptor (BCR)-mediated activation of PI3K induces the terminal differentiation factor Blimp-1 that interferes with proliferation and survival, thereby controlling the expansion of activated B cells. In fact, B-cell-specific inactivation of Pten, the negative regulator of PI3K signaling, leads to deregulated PI3K activity and elevated Blimp-1 expression.

Fiber Optic Sensor Embedment Study for Multi-Parameter Strain Sensing.

The fiber optic sensors (FOSs) are commonly used for large-scale structure monitoring systems for their small size, noise free and low electrical risk characteristics. Embedded fiber optic sensors (FOSs) lead to micro-damage in composite structures. This damage generation threshold is based on the coating material of the FOSs and their diameter.

Impact of Phytochemicals and Dietary Patterns on Epigenome and Cancer.

Cancer remains one of the leading causes of death around the world. Initially it is recognized as a genetic disease, but now it is known to involve epigenetic abnormalities along with genetic alterations. Epigenetics refers to heritable changes that are not encoded in the DNA sequence itself, but play an important role in the control of gene expression.

Platelet activation in the presence of neutral protamine Hagedorn insulin: a new feature of antibodies against protamine/heparin complexes.

Unlabelled: Essentials Protamine (PRT) is used to stabilize insulin in neutral protamine Hagedorn (NPH) insulin. The interaction between NPH-insulin, anti-PRT/heparin antibodies and platelets was investigated. Anti-PRT/heparin antibodies activate platelets in presence of NPH-insulin dependent on heparin.

Partially desulfated heparin modulates the interaction between anti-protamine/heparin antibodies and platelets.

Protamine (PRT) is the standard drug to neutralise heparin. PRT/heparin complexes induce an immune response similar to that observed in heparin-induced thrombocytopenia (HIT). Partially desulfated heparin (ODSH) was shown to interfere with anti-platelet factor 4/heparin antibodies (Abs), which are responsible for HIT.

130 mW average power, 4.6 nJ pulse energy, 10.2 ps pulse duration from an Er3+ fiber oscillator passively mode locked by a resonant saturable absorber mirror.

An Er(3+) fiber laser passively mode locked by a resonant saturable absorber mirror achieves more than 130 mW average power at 1560 nm from a Fabry-Perot cavity. The pulsed regime is self-starting from the CW regime without any Q-switch transition. The output pulse has a duration of 10.

Ultrashort pulse generation from 1.56 µm mode-locked VECSEL at room temperature.

We report on a picosecond pulse source delivering near transform-limited pulses in the 1.55 µm wavelength region, based on an optically pumped InP-based mode locked Vertical External Cavity Surface Emitting Laser (VECSEL). The cavity combines two semiconductor elements, a gain structure which includes six strained InGaAlAs quantum wells and a hybrid metal-metamorphic Bragg bottom mirror bonded onto a CVD diamond substrate, and a single quantum well GaInNAs SEmiconductor Saturable Absorber Mirror (SESAM).