Unmasking Cybercrime with Artificial-Intelligence-Driven Cybersecurity Analytics.

Cybercriminals are becoming increasingly intelligent and aggressive, making them more adept at covering their tracks, and the global epidemic of cybercrime necessitates significant efforts to enhance cybersecurity in a realistic way. The COVID-19 pandemic has accelerated the cybercrime threat landscape. Cybercrime has a significant impact on the gross domestic product (GDP) of every targeted country.

Can chronic anti-tumour necrosing factor therapy and colic polyps overwhelm a normal functioning mitral valve? A case report of an endocarditis complicated by a ruptured intracranial mycotic aneurysm.

Background: Rapid identification of endocarditis is challenging but also an important opportunity to change disease course. This is especially true when immunosuppression undermines diagnosis by mitigating symptoms that commonly accompany infectious disease, sometimes in the absence of predisposing heart valve disease as in this case presented here.

Case Summary: A middle-aged man with chronic etanercept treatment for ankylosing spondylitis, with previously well-documented normal cardiac valves, presented with afebrile chills, night sweating, weight loss, and a new mitral regurgitation at auscultation.

Effects of propranolol therapy in Moroccan children with infantile hemangioma.

Infantile hemangiomas are the most common childhood vascular tumors. Propranolol is a β-adrenergic blocker that has proven effective in the treatment of this tumor. Numerous studies around the world have been published, describing satisfactory responses in pediatric populations with a higher cure rate and fewer adverse effects than when using corticosteroids.

Compound heterozygous SLC29A3 mutation causes H syndrome in a Moroccan patient: A case report.

H syndrome is an autosomal recessive syndrome, which affects the skin and some vital organs, it is caused by mutations in the SLC29A3 gene, encoding the human equilibrative nucleoside transporter hENT3. This report describes a patient with typical features of H syndrome. Based on the patient's clinical features, SLC29A3 was selected for molecular investigation.

[Actinomycosic mycetoma of the foot in Morocco due to Actinomycetes viscosus].

We present the case of an actinomycotic mycetoma of the foot due to Actinomycetes viscosus. It evolved for nine years on the foot of a 26-year-old patient from a rural environment: Douar Inezgane (city in southern Morocco). Bacteriological study of the skin and grains confirmed the diagnosis.

[Deep-seated granulomatous pyoderma gangrenosum: A novel variant?].

Background: We report an extremely rare case of pyoderma gangrenosum with the clinical features of pyoderma gangrenosum but with unusual histopathological findings and deep massive granulomatous infiltration through the dermis.

Patients And Methods: A 15-year-old girl presented with a two-month history of deep ulcers on the lower legs and forehead. She also presented abdominal pain with diarrhea and vomiting that disappeared after symptomatic treatment.

Ten-year follow-up of a DOCK8-deficient child with features of systemic lupus erythematosus.

Dedicator of cytokinesis 8 (DOCK8) deficiency is an innate error of adaptive immunity characterized by recurrent infections with viruses, bacteria, and fungi, typically high serum levels of immunoglobulin E, eosinophilia, and a progressive deterioration of T- and B-cell-mediated immunity. DOCK8 mutations are the second most common cause of hyper-immunoglobulin E syndromes (HIES). We report a case of DOCK8 deficiency associated with systemic lupus erythematosus (SLE).

Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels.

Background: Recurrent bacterial and fungal infections, eczema, and increased serum IgE levels characterize patients with the hyper-IgE syndrome (HIES). Known genetic causes for HIES are mutations in signal transducer and activator of transcription 3 (STAT3) and dedicator of cytokinesis 8 (DOCK8), which are involved in signal transduction pathways. However, glycosylation defects have not been described in patients with HIES.

[Palmoplantar keratoderma: a rare manifestation of myxoedema].

Background: Herein we report a rare case of acquired palmoplantar keratoderma in association with myxoedema and hypothyroidism.

Patients And Methods: A 53-year-old woman presented with palmoplantar keratoderma, dry skin, muscular weakness and cramps for 9 months. The laboratory work-up revealed autoimmune thyroiditis with hypothyroidism.

[Acrodermatitis enteropathica-like disease in a full-term exclusively breast-fed infant].

Unlabelled: Symptomatic zinc deficiency can occur in exclusively breast-fed infants. We report a case in a 5-month-old infant.

Case Report: A 5-month-old exclusively breast-fed boy presented with persistent erythema of breech since the age of 2 months as well as perioral and acral erythematous scaly lesions.

[Renal ultrasound in fat necrosis].

Subcutaneous fat necrosis is an uncommon disease that may be complicated with potentially fatal hypercalcemia or with nephrocalcinosis. We report on the case of a patient with a history of significant perinatal asphyxia, hospitalized for a urinary tract infection. Lesions of subcutaneous fat necrosis were noted, with asymptomatic hypercalcemia at 3.

[Purpura fulminans, venous thrombosis and constitutional thrombophilia in an infant].

The association of idiopathic purpura fulminans (PF) and venous thrombosis (VT) seldom reveals constitutional thrombophilia in an infant. We report a case of PF in an 18-month-old infant. Laboratory tests showed disseminated intravascular coagulation (DIVC) with normal rates of C and S proteins and antithrombin.

[Generalized chromomycosis caused by Phialophora verrucosa].

Background: Chromomycosis is a chronic fungal skin infection that generally presents in the form of verrucous or vegetative lesions on uncovered areas of skin. We report an unusual case of generalised chromomycosis due to Phialophora verrucosa.

Patients And Methods: A 42-year-old town-dwelling housewife was hospitalised for erythematous keratotic nodules on the arm showing sporotrichoid distribution, associated with a crusted ulcerative lesion on the homolateral index finger, as well as subcutaneous papulonodular lesions.

c.1643_1644delTG XPC mutation is more frequent in Moroccan patients with xeroderma pigmentosum.

Xeroderma pigmentosum is a rare autosomal recessive disease characterized by hypersensitivity to UV light which is due to alterations of the nucleotide excision repair pathway. Eight genes (XPA to XPG and XPV) are responsible for the disease. Among them, the XPC gene is known to be the most mutated in Mediterranean patients.

[Pyoderma gangrenosum and Behçet's disease: a study of two pediatric cases].

Pyoderma gangrenosum is a rare neutrophilic dermatosis that affects 4% of children. It is characterized by its association in half of the cases with an underlying disease. The association with Behçet's disease is exceptional and may have a very poor prognosis.

Syringocystadenoma papilliferum: Unusual location.

Syringocystadenocarcinoma papilliferum (SCAP) is rare. We describe a 55-year-old man with a partially eroded lesion on the trunk that developed over one year. Histopathological examination revealed syringocystadenoma papilliferum.

[Cutaneous manifestations of male breast cancer].

Objective: The appearance of skin symptoms in male breast is the main reason for consultation in our context. The aim of this study is to describe the various cutaneous manifestations of male breast cancer through a series of cases collected in a dermatology department.

Methods: A retrospective study was conducted in the dermatology department at the CHU Ibn Rochd January 1988 to December 2009.

[Suppurations of the perineal and gluteal region: An aetiological study of 60 cases].

Background: The gluteal region is a complex area of the body that may be the seat of several diseases with dermatological manifestations. The purpose of this series was to study the aetiological profile of suppurative lesions of the gluteal region in patients in Morocco.

Patients And Methods: A retrospective study was carried out on patients presenting suppuration of the gluteal region hospitalised in our department between 1987 and 2008.