Publications by authors named "Khadijeh Najafi-Ghobadi"

Aim: This study evaluated surgical complication rates, recurrence-free survival, overall survival (OS), and stoma status of patients with rectal cancer after significant pathologic response following neoadjuvant treatment and curative resection. Pathologic complete response (pCR) and near-pCR patients constitute patients in our study.

Methods: Included was a retrospective cohort study of patients with rectal cancer who were diagnosed between July 2011 and September 2022 and who underwent neoadjuvant therapy and surgical resection.

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Article Synopsis
  • Toxoplasma gondii is a widespread parasite that may influence the severity of COVID-19, with studies suggesting it could either help or hinder responses to the virus.* -
  • A meta-analysis of nine studies involving 1,745 COVID-19-positive individuals was conducted, revealing a significant association between toxoplasmosis prevalence and increased COVID-19 severity, with a pooled prevalence of 48%.* -
  • Although the study indicated that toxoplasmosis is more prevalent among COVID-19 patients than in the general population, the significant variability between studies highlights the need for additional research to clarify the relationship.*
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Objective: The () gene is involved in DNA repair. Defects in DNA repair may lead to head and neck squamous cell carcinomas (HNSCCs). Several researches have focused on relationship between Arg genetic polymorphism with HNSCC's prognosis with conflicting results.

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  • Tuberculosis (TB) and HIV are interconnected public health issues, with CD4 count being a critical factor in TB/HIV co-infections.
  • A retrospective cohort study was conducted on 1,436 HIV-positive patients to explore the effects of CD4 count and other risk factors on TB and HIV-related deaths.
  • Results showed that lower CD4 counts correlated with higher mortality risk from HIV but did not significantly affect TB risk; however, TB patients had an elevated risk of dying from HIV.
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Background: HIV is one of the deadliest epidemics and one of the most critical global public health issues. Some are susceptible to die among people living with HIV and some survive longer. The aim of the present study is to use mixture cure models to estimate factors affecting short- and long-term survival of HIV patients.

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Background: Precise causes of musculoskeletal complaints among nurses are not known well, but many studies have pointed to manual patient handling tasks. Subjective judgment and decision-making process for patient lifting is crucial for gathering data regards patient handling. The aim of this study was to consider reliability and validity and re-structure of two special tools for patient handling's tasks.

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Background: The X-ray repair cross complementing group 1 (XRCC1) is a DNA repair gene. Various studies have examined the association between XRCC1 Arg194Trp polymorphism and head and neck squamous cell carcinoma (HNSCC) susceptibility with contradictory results. So, this systematic review and meta-analysis aimed to assess whether variants of this polymorphism increase the HNSCC risk or not.

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Objectives: Breast cancer (BC) is the most common cause of cancer death in Iranian women. Sometimes death from other causes precludes the event of interest and makes the analysis complicated. The purpose of this study was to identify important prognostic factors associated with survival duration among patients with BC using random survival forests (RSF) model in presence of competing risks.

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Background: Burn is a tragic event for an individual, the family, and community. It can cause irreparable physical, mental, economic, and social injury. Researches well documented that a quick visit to a healthcare center can greatly reduce burn injuries.

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Background: Drug injection has been increasing over the past decades all over the world. Hepatitis B and C viruses (HBV and HCV) are two common infections among people who inject drugs (PWID) and more than 60% of new human immunodeficiency virus (HIV) cases are PWID. Thus, investigating risk factors associated with drug use transition to injection is essential and was the aim of this research.

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Background: Meta-analysis is a statistical technique in which the results of two or more independent studies, with similar objectives, are mathematically combined in order to improve the reliability of the results. The outliers, which may exist even in random models, can affect the validity and strength of meta-analysis results.

Objectives: The current study uses "random effects variance shift model" to evaluate and correct the outliers in performing a meta-analysis study of the effect of albendazole in treating patients with Ascaris lumbricoides infection.

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