Betulinic acid and its derivatives comprehend an immense prospective toward the development of cytotoxic, antiviral, antimicrobial and antioxidant agents. Cisplatin (cytotoxic drug) divert the attentions to develop organometallic compounds with pronounced biological activities. The current study was aimed for the first time to synthesize, characterize and evaluate biologically a series of metal (Fe, Cu, Zn, Sn and Sb) complexes of betulinic acid hydrazide.
View Article and Find Full Text PDFDue to a lack of therapeutic options for the pathological condition of leishmaniasis, which is characterized by polymorphic lesions and skin surface infections, Leishmania genus parasites damaged dermis and mucosa. There was a need to synthesize and characterize some new complexes. This study evaluated the biological activities preferably anti-Leishmanial activity of organotin (IV) containing sulphonyl hydrazide derivatives.
View Article and Find Full Text PDFBackground: Alzheimer's disease (AD) is a neurodegenerative illness described predominantly by dementia. Even though Alzheimer's disease has been known for over a century, its origin remains a mystery, and researchers are exploring many therapy options, including the cholinesterase technique. A decreased acetylcholine ACh neurotransmitter level is believed to be among the important factors in the progression of Alzheimer's disease.
View Article and Find Full Text PDFPresent research work discloses new and novel synthesis of metal complexes (Fe, Cu, Zn, Sb and Sn) of 3, 4, 5-trihydroxybenzoic acid derivative containing aniline moiety with substitution at C-7 position of 3, 4, 5-trihydroxybenzoic acid in order to enhance its biological activities by coupling therapeutic values of transition metals as well. In vitro antibacterial and antifungal activities of these compounds has been performed by using agar diffusion method against different bacterial and fungal strains. The free radical scavenging assay was performed by using 2, 2-diphenyl-1-picryl-hydrazyl (DPPH).
View Article and Find Full Text PDFSaudi J Ophthalmol
December 2020
Clinical low vision evaluations provided by optometrists or ophthalmologists trained and experienced in low vision rehabilitation care should be recommended for all children with a visual impairment, regardless of the cause of their vision loss, their age or the severity of their additional disabilities. This article discusses an effective model for pediatric vision rehabilitation service.
View Article and Find Full Text PDFIn search of suitable therapy for the management of Alzheimer's disease, this study was designed to evaluate metal complexes against its biochemical targets. Zinc metal carboxylates () were evaluated against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The antioxidant in combination with anticholinesterase activity can be considered as an important target in the management of Alzheimer's disease.
View Article and Find Full Text PDFOleanolic acid (OA) is a hydroxyl pentacyclic triterpene acid (HTAs) used in various ailments. Inflammatory diseases may be profoundly influenced by iron (Fe) and zinc (Zn) status. We studied the anti-asthmatic effects of two metal complexes (Fe and Zn) of OA in the ovalbumin (OVA)-induced rat model.
View Article and Find Full Text PDFThis article provides information concerning issues related to the care of individuals who are visually impaired. Issues reviewed include determining who should be referred for vision rehabilitation services, Charles Bonnet syndrome, visual acuity, contrast sensitivity and visual field testing along with Useful Field of View testing. This article also discusses technology advances that can enhance the visual functioning of individuals who are visually impaired, including how these advances can help drivers with visual impairments to continue to safely operate motor vehicles, at least on a limited basis.
View Article and Find Full Text PDFIn thecurrent research work,eleven metal complexes were synthesized from the hydrazide derivative of ursolic acid. Metal complexes of tin, antimony and iron were synthesized and characterized by FT-IR and NMR spectroscopy. The antibacterial and antioxidant activities were performed for these complexes, which revealed that the metal complexes synthesized are more potent than their parent compounds.
View Article and Find Full Text PDFBackground: Natural products have a prime importance as an essential source for new drug discovery. Carica papaya leaves (CPL) have been used to treat inflammation in traditional system of medicine.
Aim/hypothesis: Current study evaluates the anti-inflammatory and immunomodulatory effects of CPL extract using mouse model of ovalbumin- (OVA) induced allergic asthma.
J Pediatr Ophthalmol Strabismus
May 2015
Purpose: To study the feasibility of using a nonmydriatic camera to screen children with type 1 diabetes mellitus (DM1) as young as 2 years for diabetic retinopathy.
Methods: Prospective pilot imaging study involving children with DM1 aged 2 to 17 years. The screening consisted of: (1) intake form; (2) measurement of blood pressure, pulse, and oximetry; (3) assessment of visual acuity (SIMAV, Padova, Italy); and (4) nonmydriatic color imaging (Canon CX-1 45° 15.
We investigated the use of fundus autofluorescence (FAF) imaging in screening the eyes of patients with diabetes. Images were obtained from 50 patients with type 2 diabetes undergoing telemedicine screening with colour fundus imaging. The colour and FAF images were obtained with a 15.
View Article and Find Full Text PDFObjective: To describe the use of software-assisted analysis of non-mydriatic 45° color fundus images during comprehensive ocular screening.
Materials And Methods: Software-driven filters (blue [490 nm; nerve fiber layer], green [550 nm; neural retina], and red [610 nm; pigmented retina/choroid]) and an "emboss" (topographic changes) digital filter were used to enhance image analysis during ocular health screening performed using a Canon (Tokyo, Japan) 8.2-megapixel non-mydriatic retinal camera.
The current U.S. economic recession has resulted in a loss of income, housing, and healthcare coverage.
View Article and Find Full Text PDFIncreased optic nerve head (ONH) cup-to-disc ratio (CDR) may indicate glaucoma but evaluation needs to be performed by a trained examiner. This research assessed new software to calculate CDR from ONH images. Digital stereoscopic ONH images from 28 subjects acquired during screening using a nonmydriatic 45-degree camera with 8.
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