Publications by authors named "Khadija Benlhassan"
Recovery from mild Escherichia coli O157:H7 infection in young and aged C57BL/6 mice with intact flora estimated by fecal shedding, locomotor activity and grip strength.
Comp Immunol Microbiol Infect Dis
April 2019
Article Synopsis
- Escherichia coli 0157:H7 is a harmful bacteria that primarily affects vulnerable populations, and traditional research models often cause significant suffering to lab mice.
- The study aimed to create a new method for tracking the effects of this pathogen on both young and old mice without altering their normal gut bacteria.
- By using various physiological measurements, the researchers found a reliable way to assess recovery post-infection with the goal of reducing animal suffering in drug testing.
Innovative design for a phase 1 trial with intra-patient dose escalation: The Crotoxin study.
Contemp Clin Trials Commun
September 2017
Introduction: Crotoxin has a broad antitumor activity but has shown frequent neurotoxic toxicity. To induce tolerance and limit this toxicity, we propose a new design with intra-patient dose escalation.
Methods: A new Dose Limiting Toxicity definition was used.
We investigated IL-10 and IL-6 production in amyloid-β (Aβ) stimulated peripheral blood mononuclear cells (PBMCs) in twenty Alzheimer's disease (AD) patients with slow progression, eleven with fast progression, and twenty age-matched controls. Promoter polymorphisms in IL-10 (position -592, -819, -1082), IL-6 (-174), transforming growth factor-β1 (TGF-β1) (-10, -25), interferon-γ (IFN-γ) (-874), and tumor necrosis factor-α (TNF-α) (-308) genes were analyzed. IL-10 production after Aβ stimulation was high in PBMCs from slow decliners and almost completely abrogated in fast decliners.
View Article and Find Full Text PDFBackground: Age and short leukocyte telomeres have been associated with a higher risk of Alzheimer's disease (AD). Inflammation is involved in AD and it is suggested that anti-inflammatory interleukin-10 (IL-10) may partly antagonize these processes.
Objective: The aim is to correlate telomere length (TL) in peripheral blood mononuclear cells (PBMC) from patients with AD to disease progression rate.