Comparative Study of Sutureless Fixation of Lightweight Surgical Meshes for Hernia Repair in a Rat Model.

The aim of this study was to compare the efficacy of different methods of sutureless fixation of lightweight meshes made of different polymers for repair of experimental hernias. Two lateral hernia defects were modeled in male rats and covered with polyester and polypropylene prostheses. The meshes were fixed with Histacryl glue (group 1), or self-gripping meshes were used (group 2), or the meshes were implanted without fixation (group 3).

[Pharmacoeconomic study of using solifenacin for the treatment of urge urinary incontinence in patients with overactive bladder syndrome].

Overactive bladder syndrome (OAB), accompanied by incontinence, is a relatively common disease. Currently, in the Russian Federation, unfortunately, management of patients with OAB includes the recommendations for symptomatic use of incontinence pads without pharmacotherapy. Along with this, the market is represented by a number of drugs that can reduce the occurrence of adverse symptoms associated with OAB syndrome.

[Dimensionless coefficients counted on the grounds of instrumental indices in patients with chronic cor pulmonary].

Cor pulmonary remains one of the actual tasks of modern pulmonogy, cardiology. The aim of the investigation is working-out algorithm diagnoses of cor pulmonary on the grounds of mathematical modeling and analyses of the results of several instrumental indices. The results of the investigation indices showed that worked-out by means of mathematical analyses the dimensionless coefficients permit find out the necessary instrumental indices for CP diagnose.

[Correlative analysis between indices of rheological particularities of blood, IL-1beta and lipid profile in patients with chronic cor pulmonary].

Cor pulmonary is a partial complication of majority chronic light diseases and despite its prolonged study many questions of this problem still remain unsolved and disputable, complicated diagnosis of diseases at early stages, its development, treatment is of little efficiency and the rate of deaths is high. Working-out the algorithm of the diagnosis of cor pulmonary on the grounds of mathematical modeling and analysis of laboratory indices. Worked-out dimensionless parameters of more informational indices of aggregate particularities of formal elements of blood, lipid spectrum, the level human interleukin 1beta irrespective each other with the record of permissible diapason permit diagnosing the early stages of disease, estimate its dynamics and make provisions against its further development.

[Protonation of nitrite is an obligatory stage in the generation of nitric oxide from nitrite in biological systems].

The yield of nitric oxide from 1 mM sodium nitrite differs 200 times when the process was initiated by 10 mM sodium dithionite in the solution of 5 or 150 mM HEPES-buffer (pH 7.4). Dithionite acted both as a strong reductant and an agent that induced a local acidification of solutions without notable change in pH value.

[Formation of paramagnetic nitrosyl complexes of non heme iron in animals with participation of nitric oxide from exogenous and endogenous sources].

It was found that thiosulfate has a stabilizing effect on exogenous and endogenous dinitrosyl-iron complexes in mice treated with bacterial lipopolysaccharide. It was assumed that thiosulfate protects dinitrosyl-iron complexes from the destructive influence of superoxide and peroxinitrite whose enhanced synthesis, together with the synthesis of nitric oxide, is initiated in mice by the lipopolysaccharide. For the first time, the formation of dinitrosyl-iron complexes was demonstrated, which occurs with the participation of nitric oxide generated enzymatically via the L-arginine-dependent pathway.

L-Lysine-2-monooxygenase production by strains of Pseudomonas fluorescens and P. putida.

Twelve strains of Pseudomonas fluorescens and P. putida were grown in a synthetic medium that contained L-lysine as the only source of carbon and nitrogen, and screened for L-lysine-2-monooxygenase production. Best production was by P.

[The computerized evaluation of the signs of duodenal peptic ulcer].

A mathematical analysis of the data bank collected on duodenal ulcer patients has been performed using adapted to computer processing coded disease histories. Most informative signs of ulcerogenesis, diagnostic indicators of peptic ulcer have been selected and ranged. The review of peptic ulcer diagnostic criteria is presented.

A biosensor for L-proline determination by use of immobilized microbial cells.

A biosensor to quantify L-proline within 10(-5)-10(-3) mole/L concentration is described. Immobilized Pseudomonas sp. cells grown in a medium containing L-proline as the only source of carbon and nitrogen were used to create the biosensor.

[Cytogenetic effect of the antineoplastic anthracycline antibiotic 4'-epidoxorubicin].

Cytogenetic action of 4'-epidoxorubicin (farmorubicin), an antitumor antibiotic was studied with using rat bone marrow cells. It was shown that after intraperitoneal administration the antibiotic increased the number of the aberrant metaphases when the dose was not lower than that equivalent to 1/30 of the LD50. The number of the aberrant metaphases increased with increasing of the antibiotic dose.

[Isolation, purification and various properties of L-lysine-2-monooxygenase from Pseudomonas putida].

Isolation and purification of L-lysine-2- monooxygenase from the bacterium Pseudomonas species was carried out. The purification procedure included ammonium sulfate fractionation, acid treatment, gel filtration through Sephadex G-200 and ion-exchange chromatography on DEAE-Sephadex A-50. Such treatment resulted in more than 220-fold purification and 22% yield; the specific activity of the enzyme is 14.

[Hemodynamics of pulmonary circulation in hypertension based on data from radionuclide studies].

The authors presented the results of a combined radionuclide study of the state of pulmonary hemodynamics in patients with essential hypertension. Altogether 132 patients were investigated. Radiocardiography, perfusion scintigraphy and a study of the regional pulmonary blood flow using radioactive Xe were conducted.

[Changes in cerebral circulation in arterial hypertension].

The state of the cerebral blood flow in essential hypertension has been studied in relation to various clinical and hemodynamic parameters. The authors emphasize that the regulation of the cerebral blood flow depends to a great degree on the level of the systolic and pulse pressure as well as on the type of hemodynamics.

[Phosphorylation of creatine and the membrane potential of heart mitochondria].

The method of penetrating ions was used to measure the membrane potential and to study the creatine phosphokinase reaction in rat heart mitochondria. The concentration of adenine nucleotides in the intermembrane space at different levels of the membrane potential was estimated. The role of the diffusional layer adjacent to the inner membrane of heart mitochondria for coupling of the creatine phosphokinase reaction with oxidative phosphorylation is discussed.

[Effect of creatine phosphate synthesis on the membrane potential of mitochondria].

The method of the penetrating ions allows to observe the creatine phosphokinase function of heart mitochondria in steady state conditions. The addition of ADP to respiring mitochondria decreases the membrane potential in the course of the ATP synthesis. The subsequent addition of creatine decreases the membrane potential for a long period of time because of ADP formation in creatine phosphokinase reaction.

[Possible role of neuropeptides in regulating nucleic acid biosynthesis in the brain].

It has been studied the role of intracysternal administration of neuropeptides--five analogous of 8-lysinvasopressin (LVP) [Des-9-Gly-cine-amide-LVP (DGLVP), Tri-Gly-LVP, deamino-LVP (1--beta-mercaptopropionic acid-LVP), Leu4-LVP, Asn1,6-LVP] and two cardiotrop hexapeptides (acetylated and non) separated from the hypothalamus in the regulation of various types of RNA (GC and AU types n-RNA, r-RNA, t-RNA) biosynthesis in the brain. Using the combined method of phenol extraction, differential ultracentrifugation, gel-filtration and ultraviolet spectroscory of various types of RNA has been shown the increase in the content of r-RNA and t-RNA under the influence of DGLVP, Leu4-LVP and cardiotrop hexapeptide. Deamino-LVP, Tri-Gly-LVP and acetylated hexapeptide stimulate the rise in the content of r-RNA and AU type n-RNA (precursor of m-RNA).