[The toxicological characteristics of ammonium glycyrrhizinate (glycyram). A study of its acute and subacute toxicity].

A single parenteral and oral administration of ammonium glycyrrhizinate in rat and mice experiments showed that the compound is related to practically nontoxic drugs. Its repeated administration (30 times) into the stomach in a maximum daily therapeutic dose (7 mg/kg) and in a four-fold dose (28 mg/kg) did not cause signs of intoxication, essential changes in the hematological and integral parameters, shifts in the activity of serum enzymes, morphological changes in the cell structures of the internal organs. Administration of the drug in a dose of 28 mg/kg for a second time led to changes in the activity of some enzymes in the brain, the development of parenchymatous dystrophy of the liver which changed to acidophilic necrosis attended with signs of regeneration.

[The toxicological characteristics of Gastrofenzin. III. Its chronic oral toxicity].

A risk evaluation has been carried out under conditions of chronic three-month experiment in oral application of Gastrofenzin in doses 1/20, 1/100 and 1/200 LD50 for male and female white rats, respectively 33.2 and 43.8; 6.

[The toxicological characteristics of Gastrofenzin. II. Its subacute oral toxicity].

The subacute (30 day) oral toxicity of Gastrofenzin has been investigated in white rats "Wistar" of both sexes, treated with 0.7 and 33 mg.kg-1 for the male and 0.

[The toxicological characteristics of Gastrofenzin. I. Its acute toxicity (oral, subcutaneous and intravenous)].

The acute toxicity of the antiulcer drug "Gastrofenzin", synthesized in Bulgaria has been studied in oral, subcutaneous and intravenous application in white rats "Wistar" and white mice "ICR". The main toxicometric parameters (LD50, LD16, LD84 and others) have been determined. The clinical picture of intoxication is characterized mainly by symptoms deriving from in the central and vegetative nerve system.

[An experimental study of the effect of an artichoke preparation on the activity of the sympathetic-adrenal system in carbon disulfide exposure].

Artichoke, a new Bulgarian preparation based on the plant Cynara scolymus, was tested for influence on sympatho-adrenal system (SAS) activity in experimental inhalation exposure to carbon disulfide. This chronic (six-month) inhalation experiment was done on Wistar albino rats of either sex. Activity of SAS was assessed through excretion of noradrenalin and adrenalin.

[A comparative evaluation of the toxic and cumulative properties of the Takal drug group].

The acute oral and dermal toxicity was studied as well as subacute oral toxicity [30 successive days] and skin irritating effect on experimental animals of new drug form "Takal 9", "Takal 14" and "Takal 16" with proved bactericidal and virucidal activity. A complex of toxicometric, unspecific, haematological, biochemical and histological studies were performed. The compositions "Takal 9", "Takal 14" and "Takal 16" are slightly toxic at oral and dermal application.

[The action of the artichoke (Cynara scolymus) on the male gonads in an experiment].

The gonadotropic effect of the Bulgarian preparation artichoke, developed on the basis of Cynara scolymus is studied. The preparation is used under the form of 50% aque emulsion, stabilized by emulgent Twin-80, in doses 35.70 and 150 mg/kg-1, 5 times weekly for 75 days.

[The acute toxicity of a bacterial insecticidal preparation containing a beta-exotoxin].

The acute toxicity of a new Bulgarian bioinsecticide preparation is determined, produced on the basis of Bacillus thuringiensis containing 0.1% beta-exotoxin by oral, dermal, inhalational and intraperitoneal introduction in experimental animals. The evaluation of the toxicity is performed by a complex of toxicometric, integral, haematologic and pathologicoanatomic methods according to the WHO and USA criteria for studying the safety of the microbic agents for plant protection.

[The acute toxicity of the microbial preparation bulmoscide].

The acute toxicity of a new Bulgarian microbial preparation bulmoscid on the basis of Bacillus thuringiensis H-14 in the conditions of oral, dermal, inhalation and intraperitoneal introduction in experimental animals is determined. The assessment of toxicity is made by using toxicometric, integral, hematologic, histologic and microbiologic methods in accordance with Bulgarian and international criteria and standards. It is established, that the preparation bulmoscid introduced orally in dose 5500 mg.

[An experimental evaluation of the acute and chronic oral toxicity of the antibiotic Bactericin for plant protection].

In relation to the future implementation of the antibiotic bactericin in agriculture are carried out acute, subacute and chronic oral experiments on 128 male white rats and 88 female. In order to determine the parameters of acute oral toxicity, doses (200, 120, 80, 60, 50, 40 mg/kg) of the preparation dissolved in polyethylene glycol are applied. In the subacute--1/10 and 1/20 LD50, and in the chronic (four months)--1/50 and 1/100 LD50.

[The hygienic toxicological evaluation of the viral preparation Mamestrin].

The preparation "Mamestrine" developed in Bulgaria on the basis of NPV virus is meant for control of the Heliothis zea. Experiments are carried out on the toxic effect of the preparation, according to the requirements of FAO/WHO for assessment of the virus preparations and the acting in this country Bulgarian State Standards. On experimental animals (white rats of both sexes, white guinea pigs and white rabbits) are studied acute oral, dermal and inhalatory toxicity, subacute oral toxicity, dermal-irritation, eye-stimulation and skin-sensitizing activity, cytotoxicity and activity of the preparation in soils and waters.

[Biochemical changes in the brain tissue of white rats exposed to the herbicide acetochlor under acute and subacute oral experimental conditions].

In the conditions of acute and subacute oral intoxication with acetanilidic preparation acetochlorine applied in doses respectively 1/5 LD50 for acute experiment and 1/20 and 1/100 LD50 for subacute experiment (LD50 for male animals--1063 mg/kg-1, and for females--768 mg/kg-1) are traced the changes in the capacity for methaemoglobin formation, the quantity of sulfhydryl groups in the serum, the activity of LDH, G-6-PhDH, IDH, MDH, SDH, Cyt Oxidasis and the quantity of soluble proteins in brain homogenates and isolated mitochondria of brain. The animals of the acute experiment are examined on the 1, 3, 5, 7, 10 and 14 day of the poisoning, and the animals of the subacute experiment--on the 24th hour after the last administration (42-day treatment with the preparation, 5 days weekly). The herbicide acetochlorine at unrepeated introduction of dose 212 6 mg/kg-1 (1/5 LD50) and multiple administration for a period of 42 days in doses 1/20 and 1/1000 LD50 in the stomach of white rats possess well expressed methaemoglobin formation capacity.

[Virulence of the microbial preparation Bactorodencide for various animal species].

The virulence of the biological preparation for plant protection Bactorodencite is studied in 6 species of wild and domestic animals and game. Its high specificity concerning rodents is established at the highest rate in Ratus Norvegicus and inbred mice - C57 Black. Indocile to S.

[Experimental research on the chronic inhalational toxicity of chloracetophon].

The chronic inhalational toxicity of chloracetophon was studied on 24 albino Wistar rats, with concentrations 20 mg X m-3. The animal were exposed 4 hours/daily, 5 days/weekly, for 90 days. Integral, biochemical, histological and electron-microscopic methods were used for the evaluation of the toxic effect of the preparation.

[Evaluation of inhalation toxicity of organic solvent xylene in pregnant rats].

The objective of the present experimental study was the assessment of organism susceptibility to the toxic xylene effect during gestation period, with a view to elaborating recommendations for female work protection. The experiments were carried out in a comparative aspect in 60 pregnant and 60 virgin, sexually matured female albino rats, exposed to 1850 and 467.8 mg/m3 technical xylene in inhalation chambers--levels 40 and 10 times higher than MAC of the solvent, in the course of 21 days (period of gestation of rats), 5 hours daily, 5 times a week.

[Effect of halothane (narcothane) on intrauterine fetal development].

The authors examined the effect of chalotane (narcotann ne-Spofa) on the development of a rat fetus. The rats were divided into groups and were narcotised for a period of 4 hours as well as 4.5 days.