ANALYSIS OF ANTIDIABETIC THERAPY FOR TYPE 2 DIABETES IN PRIMARY HEALTH CARE (WESTERN KAZAKHSTAN).

Diabetes Mellitus Type 2 (T2D) represents a significant global health challenge, with increasing prevalence and the need for effective management strategies. Despite the widespread nature of the disease, there is disagreement regarding the optimal glycemic targets for patients with Type 2 diabetes. The American Diabetes Association recommends aiming for an HbA1C level of less than 7% (53 mmol/mol).

EPIDEMIOLOGY OF GENES ASSOCIATED WITH OBESITY IN ASIAN POPULATION. LITERATURE REVIEW.

Among the general population, there is a category of individuals with an innate predisposition to obesity. In recent decades, the increase in the prevalence of obesity and related diseases worldwide indicates the need to study the etiological factors associated with its development. At present, it is still unknown how many genes are involved in the pathophysiology of obesity, and many studies are underway to identify "candidate genes" in clinical medicine.

[INFLUENCE OF METFORMIN ON THE DIAMETER AND NUMBER OF DNA BREAKS IN BLOOD LYMPHOCYTES IN OBESITY].

Aim - to assess the DNA damage of lymphocytes before and after the use of Metformin in obese individuals by two indicators: the diameter and the number of DNA breaks in blood lymphocytes. The sample included 27 obese patients aged 18-61 years. Among the participants, persons with chronic decompensated diseases, with bad habits (smokers, drug users, alcohol) were excluded.

[MARKERS OF OBESITY IN CLINICAL RESEARCH AND PRACTICAL MEDICINE (REVIEW)].

The purpose of this article is to describe the state-of-the-art knowledge of risk factors and targetmarkers of obesity needed for personalization of disease prevention. The frequency of diagnosis of obesity depends to a large extent on how it is determined. In the clinical evaluation of a patient with obesity, it is necessary to assess the anthropometric, metabolic and functional status of organs and systems.

[DNA DAMAGE AND THEIR CONNECTION WITH EXCESSIVE BODY MASS AND OBESITY (REVIEW)].

The aim of this article is to describe the current level of knowledge about the relationship between overweight and genomic instability. The relationship between overweight / obesity and cancer has been well studied in numerous studies. A feature of overweight and obesity is the formation of reactive oxygen species and cytokines, which lead to damage to the genetic material of the cell.