[An evaluation of the toxic and antitumor action of farmorubicin administered to H-strain mice with Ehrlich ascitic cancer].

The toxic and antitumour action of farmorubicin was investigated in experiments on mice. Data on the high antitumor activity were obtained after single application of the drug and at 5-day treatment of mice bearing the Ehrlich ascites tumour. It has been established that farmorubicin used in the tolerant dose was comparatively nontoxic--nonmyelotoxic.

[Experimental pharmacologic and morphologic study of new platinum complexes].

Antineoplastic and toxic properties of two newly synthesized complexes of platinum (II)--with isovaleric acid and with cystine, were studied on mice with ascitic tumour of Ehrlich. The studies were compared with cis-diaminodichloroplatinum (II) (cisplatinum). Data were obtained for high antineoplastic activity and inhibiting influence of the synthesis of DNA of cisplatinum.