[The comparative characteristics of disease prevalence and the structure of mortality in women of reproductive age].

Incidence rate of some diseases and mortality have been analyzed basing on the examination of 714 females aged 18-50 and 176 fatal outcomes in 23-82-year-old females. The disease prevalence and death rate showed the trend to an increase with growing number of deliveries. Multiparas die more frequently of cardiovascular diseases the risk of which proved the highest in the group of multiparas over 45 years of age.

[Effect of mevinolin and glycyrrhizinic acid on cholesterol and bile acid metabolism in cultured rabbit hepatocytes].

A comparison of effects of two hypocholesterolemic drugs--mevinolin and glycyrrhizinic acid, on cholesterol and bile acid metabolism in cultured rabbit hepatocytes has been carried out. The following parameters have been determined: i) cholesterol synthesis from [2-14C]acetate; ii) bile acid production from newly synthesized and [4-14C]-labeled HDL2 cholesterol, and, iii) total cholesterol efflux into the incubation medium Mevinolin (0.5 microgram/ml) inhibited [2-14C] acetate incorporation into cholesterol by more than 90%.

[Clinical use of chloranolol (tobanum) in essential hypertension patients].

A clinical study of the efficiency of a new beta-blocker, chloranolol (Tobanum, Hungary), was carried out in 24 patients with second-stage essential hypertension. Central and intracardiac hemodynamics, left-ventricular myocardial function (echocardiography) and regional hemodynamics (occlusion plethysmography) were assessed in 14 patients before treatment and on days 10-15 and 25-30 of chloranolol administration. During the fourth or fifth week of chloranolol treatment, arterial BP diminished by 12/10% (p less than 0.

[Regression of left-ventricular myocardial hypertrophy in patients with hypertension during long-term treatment with beta-adrenergic blockaders].

Thirty-nine patients with second-stage essential hypertension were treated with Beta-adrenoblockers of different classes for 2.5 to 3 years. Two groups of patients were distinguished: 23 patients showing a regression of left-ventricular myocardial weight (group 1) and 16 patients without such developments (group 2).

[Condition of the tissue oxygen regime of patients with essential hypertension with different types of hemodynamics].

Systemic and regional hemodynamic parameters were investigated using echocardiography, venous-occlusion plethysomography, and tissue oxygen regimen was studied polargraphically, in 51 patients with essential hypertension. Tissue oxygen supply becomes increasingly inadequate as the disease progresses, as reflected in limited oxygen delivery to tissues, its reduced utilization, and smaller reserve capacities of oxygen transport at the microcirculatory level. In patients with hyperkinetic circulation, increased blood stroke volume was combined with a significant increase in baseline tissue oxygen tension and the capillary-to-tissue oxygen diffusion rate, while changes in the resistive vascular element were basically functional.

[Treatment of hypertension with the calcium antagonist korinfar and its combination with obzidan].

A hypotensive effect of corinfar and its effect on the indices of the central and peripheral hemodynamics were studied in 50 patients with stage II hypertension. In 3 weeks BP was lowered at the expense of a considerable decrease in the total peripheral vascular resistance (TPVR) (by 29.6%) and regional vascular resistance (by 48%).

[Prolonged use of beta-blockers in patients with essential hypertension and different degrees of severity of left ventricular hypertrophy].

The paper is concerned with analysis of the results of therapy with beta-blockers of different classes of 56 patients (over 2.5-3 yrs) with essential hypertension and analysis of the time course of the structural-functional states of the left ventricular myocardium with various degree of expression of left ventricular hypertrophy (LVH). The patients were divided into 3 groups: the 1st group--14 persons (the left ventricular myocardial mass/LVMM/up to 150 g); the 2nd group--19 persons (the LVMM up to 200 g); the 3rd group--23 persons (the LVMM over 200 g).

[Characteristics of left ventricular hypertrophy in patients with different forms of arterial hypertension based on echocardiographic data].

Echocardiographic investigation of 110 patients with different forms of stable arterial hypertension demonstrated a moderately close correlation between left-ventricular myocardial weight, and systolic and diastolic arterial blood pressure in patients with essential hypertension and chronic diffuse glomerulonephritis, and a weak correlation between left-ventricular myocardial weight and systolic pressure in patients with renovascular hypertension and chronic unilateral or predominantly unilateral pyelonephritis. Inadequate left-ventricular hypertrophy has similar incidence (15-20%) in patients with different forms of arterial hypertension, whereas excessive hypertrophy only occurs in patients with essential hypertension. The frequency of asymmetrical hypertrophy differs in the two groups.

[Ambulatory treatment of hypertension with the beta-blockader corgard (nadolol)].

Fifteen outpatients with stage II essential hypertension were treated with corgard, a non-cardioselective beta-blocker, for 12-15 months. Study (in 12 patients) of the shifts in the central and intracardiac hemodynamics (by EchoCG for 3-4 months) demonstrated that a 24-25% decrease in the blood pressure occurred at the expense of a significant reduction in the cardiac index (by 25.6%) and heart rate (by 29%).

[Evaluation of the effectiveness of the long-term treatment of hypertension patients. I. Changes in hemodynamics and myocardial function].

Altogether 106 patients with stage II essential hypertension (EH) were treated for a long time (up to 3 years) with beta-blockers belonging to different classes. In some cases beta-blockers were administered in combination with vasodilators and/or a diuretic. In 66 patients, prolonged continuous treatment led to an appreciable drop in blood pressure (BP) due to the reduction of both the cardiac index and the total peripheral vascular resistance (TPVR), particularly in patients with stage IIB essential hypertension treated with a cardioselective beta-blocker tenormine or an alpha- and beta-blocker trandate.

[Therapeutic effect of the beta-adrenergic receptor blocker corgard (nadolol) and its effect on hemodynamics in hypertensive patients].

The therapeutic effect of the non-cardioselective beta-blocker corgard (nadolol) was examined in 40 patients with stage II essential hypertension. In 22 of those, central, intracardiac and regional hemodynamics were measured echocardiographically and rheographically after 2 and 4 weeks of treatment. Blood pressure dropped significantly by days 8-13 of treatment, as a result of cardiac index reduction mainly due to decreased heart rate.

[Therapeutic effect of the cardioselective beta-blocking agent tenormin and its action on the indices of systemic, intracardiac and regional hemodynamics in patients with hypertension].

Cardioselective beta-blocking agent tenormin (atenolol) was used in 55 patients with essential hypertension, Stage II; in 20 of those, central, intracardiac and regional hemodynamics were assessed echocardiographically and rheographically. Tenormin produced a pronounced hypotensive effect within 2-4 weeks of treatment (BP decreasing by 26.8/22.

[Comparative evaluation of the therapeutic effect of various classes of beta-blockaders in patients with hypertension].

A complex study of changes of hemodynamics and myocardial performance was conducted while treating 215 hypertensive patients with obsidan (propranolol), corgard, a cardioselective beta-blocker tenormine and alpha- and beta-blocker trandate. Different hypotensive efficiency and varying hemodynamic mechanisms of its action were found. Obsidan and corgard were mainly efficient in moderate hypertension and marked hypersympathicotonia.

[Therapeutic effect of trandat, an alpha- and beta-adrenergic receptor blockader, and its effect on central, regional and intracardiac hemodynamics].

A study of the effect of labetalol (trandat) was carried out in 75 arterial hypertensive patients. The central, regional, and intracardial hemodynamics were studied in 40 of them by echocardiography and rheography. A 25% decrease in BP and subjective improvement were observed on the 1-2 week of treatment.