Involvement of microRNA-146a-5p, but not -155-5p and -29b-5p, in left ventricular remodeling and dysfunction in spontaneously hypertensive rats.

The contribution of microRNAs remain poorly understood in the context of hypertensive cardiac pathology. The role of miR-146a-5p, miR-155-5p, and miR-29b-5p in cardiac hypertrophy and dysfunction was investigated in spontaneously hypertensive rats (SHR). Seven-month-old SHR (n=7 male, n=9 female), and normotensive Wistar Kyoto rats (WKY; n=7 male, n=9 female) underwent echocardiography.