Publications by authors named "Keziah Chang"
Biocatalysis using whole cell biotransformation presents an alternative approach to producing complex molecules when compared to traditional synthetic chemical processes. This method offers several advantages, including scalability, self-contained co-factor recycling systems, the use of cost-effective raw materials, and reduced purification costs. Notably, biotransformation using microbial consortia provides benefits over monocultures by enhancing biosynthesis efficiency and productivity through division of labor and a reduction in metabolic burden.
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- Researchers fused inactive Cas13 proteins with a modified human ADAR2 deaminase to create a new method for precise RNA editing without causing permanent changes in the genome.
- The new platform, called xPERT, was engineered to improve the balance between effective on-target editing and reduced off-target activity, addressing a major concern in existing RNA-editing technologies.
- Compared to previous systems (REPAIRv1 and REPAIRv2), xPERT demonstrates strong on-target editing while minimizing unintended alterations, making it a potentially safer option for customizing RNA and protein functions.