A New Scientific Medical Model: Improvement of the Current Biopsychosocial Medical Models.

The current biopsychosocial medical models have substantial limitations and require to form an improved scientific medical model. This new model should consider human health holistically, emphasizing the integrity of life and focusing on the impact of physiological spaces, natural factors, and the interaction between individuals and their environment. We propose a "life-society-nature medical model" that provides novel perspectives for innovation in basic medical theory, the integration of Traditional Chinese and Western medicine, disease diagnosis, therapy and prevention, as well as the development of new therapeutic agents, scientific instruments, and approaches to medical education.

Multi-ion detection chemosensor based on rhodamine for turn-on fluorescence sensing and bioimaging of Fe, Al, Cr, and Hg under different channels.

A novel rhodamine-based multi-ion fluorescent sensor, RGN, was designed and synthesized for the highly selective detection of mercury ions (Hg) in ethanol and water systems, as well as trivalent cations (Fe, Al, and Cr) in acetonitrile and water systems using a two-step Schiff base reaction method. Nuclear magnetic titration experiments and theoretical calculations demonstrated that the sensor achieved the detection of the aforementioned metal ions through the fluorescence turn-on phenomenon induced by lactam ring-opening. Density functional theory (DFT) calculation results showed decreased HOMO-LUMO energy gaps and increased dipole moments, indicating the effective coordination of the sensor with the corresponding metal ions to form more stable complexes, thereby achieving detection objectives.

Preparation and mechanism study of hydrogen bond induced enhanced composited gelatin microsphere probe.

Fluorescent probes offer rapid and efficient detection of metal ions. However, their properties, including high biotoxicity and low detection limits, often limit their utility in biological systems. In this study, we used a microfluidic approach to fabricate photocrosslinked gelatin microspheres with a micropore, providing a straightforward method for loading fluorescent probes into these microspheres based on the adsorption effect and hydrogen bonding interaction.

A novel polyhedral oligomeric silsesquioxane nanohybrid fluorescent sensor designed based on an osmotic mechanism for specific detection and intelligent scavenging of magnesium ions.

Background: Mg has long been recognized as one of the most vital cations due to its diverse physiological and pathological roles, making it indispensable in both biomedical and biological research. Organic fluorescent sensors are commonly employed for Mg detection, but they often lack high selectivity and exhibit poor hydrophilicity, limiting their biomedical applications.

Results: Herein, we introduced a novel organic-inorganic hybrid fluorescence sensor, PFHBS, constructed on the POSS nanoplatforms.

Novel multifunctional nano-hybrid polyhedral oligomeric silsesquioxane-based molecules with high cell permeability: molecular design and application for diagnosis and treatment of tumors.

Chemotherapy mostly functions as a carrier for direct drug delivery to the tumor, which may induce secondary damage to healthy tissue cells around the tumor. To avoid this side effect, using multifunctional drugs with high cell permeability during chemotherapy is crucial to achieve significant antitumor efficacy. In this study, polyhedral oligomeric silsesquioxane-based multifunctional organic-inorganic hybrid molecules with potential for recognition, imaging, and treatment were designed and successfully synthesized through a facile and efficient one-pot reaction process.

The Significance of Physiological Spaces in the Body and Its Medical Implications.

The human body is made up of physical structures and spaces. These physiological spaces play an integral role in metabolic processes. In previous scientific research, these spaces were often neglected.