Publications by authors named "Kezban N Gunes"
The aim of this study was to evaluate the oxidative DNA damage, antioxidant activity, and effects of antihypertensive drugs on oxidative stress in hypertensive patients with different stages of chronic kidney disease (CKD). Fifty-three non-dialyzed hypertensive CKD patients were included by the study. Serum and urinary 8-hydroxydeoxy guanosine (8-OHdG) levels (as a marker of oxidative DNA damage), serum superoxide dismutase (SOD), and glutathione peroxidase (G-Px) activities (as antioxidant enzymes) were measured.
View Article and Find Full Text PDFArticle Synopsis
- Chronic inflammation can lead to cancer risk due to DNA damage and the accumulation of harmful products.
- Endogenous antioxidant enzymes help combat these effects, but their efficacy can vary in individuals with conditions like inflammatory bowel disease (IBD).
- In a study, patients with IBD had higher levels of DNA damage markers and antioxidant activity, suggesting a potential link to an increased risk of colon cancer.
Oxidant/antioxidant balance has been suggested as an important factor for initiation and progression of cancer. In order to determine whether the degree of oxidative DNA damage and antioxidant enzyme activities in plasma obtained from patients with gastric and colon cancer who undergo resection can be used as a useful prognostic predictor, plasma level of 8-hydroxydeoxyguanosine (8-OHdG), activities of glutathione peroxidase (G-Px) and superoxide dismutase (SOD) were examined. 19 patients with gastric cancer and 26 patients with colon cancer who were undergoing resection of tumor were included by the study.
View Article and Find Full Text PDF