Publications by authors named "Kezban Korkmaz Bayram"
Introduction: Traumatic brain injuries (TBIs) pose a high risk of pituitary insufficiency development in patients. We have previously reported alterations in miR-126-3p levels in sera from patients with TBI-induced pituitary deficiency.
Methods: To investigate why TBI-induced pituitary deficiency develops only in some patients and to reveal the relationship between miR-126-3p with hormone axes, we used mice that were epigenetically modified with miR-126-3p at the embryonic stage.
Article Synopsis
- - Environmental factors can alter disease-related RNA transcripts, notably non-coding RNAs (ncRNAs), which may be linked to heritability and disease transmission, though the mechanisms remain unclear.
- - Experiments with genetically diverse mice on a high-fat diet show that certain mouse lines retain their traits, while sperm RNA from these mice can pass on obesity/diabetes phenotypes to susceptible offspring.
- - The study introduces the idea that ncRNAs attached to DNA in sperm may influence epigenetic changes, suggesting that variations in RNA retention could be used as markers for understanding these disease-related changes.
Activation of the hypothalamic-pituitary-adrenal (HPA) axis using an insulin tolerance test (ITT) is a medical diagnostic procedure that is frequently used in humans to assess the HPA and growth-hormone (GH) axes. Whether sex differences exist in the response to ITT stress is unknown. Thus, investigations into the analysis of transcripts during activation of the HPA axis in response to hypoglycemia have revealed the underlying influences of sex in signaling pathways that stimulate the HPA axis.
View Article and Find Full Text PDFArticle Synopsis
- * In a study of 45 children with ASD, six specific microRNAs were found at significantly lower levels in their serum compared to healthy controls, and similar patterns were observed in unaffected parents and siblings.
- * Mouse models of ASD also showed a consistent microRNA profile, suggesting a genetic link and potential for early identification of ASD, which could lead to better diagnostic methods in the future.